{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:29:45Z","timestamp":1791955785668,"version":"4.3.4"},"reference-count":20,"publisher":"Jaypee Brothers Medical Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.4103\/0972-5229.130571","type":"journal-article","created":{"date-parts":[[2014,4,14]],"date-time":"2014-04-14T06:06:26Z","timestamp":1397455586000},"page":"205-211","source":"Crossref","is-referenced-by-count":10,"title":["Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis"],"prefix":"10.5005","volume":"18","author":[{"given":"John","family":"Peter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Ramakrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Pugazhendhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakanthan","family":"Kabeerdoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","published-online":{"date-parts":[[2014]]},"reference":[{"key":"ref=1","doi-asserted-by":"crossref","unstructured":"1. Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: A novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013;13:260-8.","DOI":"10.1016\/S1473-3099(13)70001-X"},{"key":"ref=2","doi-asserted-by":"crossref","unstructured":"2. Thair SA, Russell JA. Sepsis in transit: From clinical to molecular classification. Crit Care 2012;16:173.","DOI":"10.1186\/cc11813"},{"key":"ref=3","doi-asserted-by":"crossref","unstructured":"3. Zhao Y, Tao L, Jiang D, Chen X, Li P, Ning Y, et al. The -144C\/A polymorphism in the promoter of HSP90 beta is associated with multiple organ dysfunction scores. PLoS One 2013;8:e58646.","DOI":"10.1371\/journal.pone.0058646"},{"key":"ref=4","doi-asserted-by":"crossref","unstructured":"4. Cardinal-Fern\u00e1ndez P, Ferruelo A, El-Assar M, Santiago C, G\u00f3mez-Gallego F, Mart\u00edn-Pellicer A, et al. Genetic predisposition to acute kidney injury induced by severe sepsis. J Crit Care 2013;28:365-70.","DOI":"10.1016\/j.jcrc.2012.11.010"},{"key":"ref=5","doi-asserted-by":"crossref","unstructured":"5. Kothari N, Bogra J, Abbas H, Kohli M, Malik A, Kothari D, et al. Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock. Cytokine 2013;61:676-81.","DOI":"10.1016\/j.cyto.2012.11.016"},{"key":"ref=6","doi-asserted-by":"crossref","unstructured":"6. Song Z, Song Y, Yin J, Shen Y, Yao C, Sun Z, et al. Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality. PLoS One 2012;7:e46113.","DOI":"10.1371\/journal.pone.0046113"},{"key":"ref=7","doi-asserted-by":"crossref","unstructured":"7. Salomao R, Brunialti MK, Rapozo MM, Baggio-Zappia GL, Galanos C, Freudenberg M. Bacterial sensing, cell signaling, and modulation of the immune response during sepsis. Shock 2012;38:227-42.","DOI":"10.1097\/SHK.0b013e318262c4b0"},{"key":"ref=8","doi-asserted-by":"crossref","unstructured":"8. Wong HR. Genetics and genomics in pediatric septic shock. Crit Care Med 2012;40:1618-26.","DOI":"10.1097\/CCM.0b013e318246b546"},{"key":"ref=9","doi-asserted-by":"crossref","unstructured":"9. Schr\u00f6der O, Schulte KM, Ostermann P, R\u00f6her HD, Ekkernkamp A, Laun RA. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. Crit Care Med 2003;31:73-9.","DOI":"10.1097\/00003246-200301000-00011"},{"key":"ref=10","doi-asserted-by":"crossref","unstructured":"10. Qi Y, Niu WQ, Zhu TC, Liu JL, Dong WY, Xu Y, et al. Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4000 meters. Clin Chim Acta 2009;405:17-22.","DOI":"10.1016\/j.cca.2009.03.056"},{"key":"ref=11","doi-asserted-by":"crossref","unstructured":"11. He M, Guo H, Yang X, Zhang X, Zhou L, Cheng L, et al. Functional SNPs in HSPA1A gene predict risk of coronary heart disease. PLoS One 2009;4:e4851.","DOI":"10.1371\/journal.pone.0004851"},{"key":"ref=12","doi-asserted-by":"crossref","unstructured":"12. Schroeder S, Reck M, Hoeft A, St\u00fcber F. Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis. Crit Care Med 1999;27:1265-70.","DOI":"10.1097\/00003246-199907000-00006"},{"key":"ref=13","doi-asserted-by":"crossref","unstructured":"13. Waterer GW, ElBahlawan L, Quasney MW, Zhang Q, Kessler LA, Wunderink RG. Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia. Crit Care Med 2003;31:1367-72.","DOI":"10.1097\/01.CCM.0000063088.86079.03"},{"key":"ref=14","doi-asserted-by":"crossref","unstructured":"14. Temple SE, Cheong KY, Ardlie KG, Sayer D, Waterer GW. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. Intensive Care Med 2004;30:1761-7.","DOI":"10.1007\/s00134-004-2359-5"},{"key":"ref=15","doi-asserted-by":"crossref","unstructured":"15. van Gestel A, Bakker J, Veraart CP, van Hout BA. Prevalence and incidence of severe sepsis in Dutch intensive care units. Crit Care 2004;8:R153-62.","DOI":"10.1186\/cc2858"},{"key":"ref=16","doi-asserted-by":"crossref","unstructured":"16. Nam SY, Kim N, Kim JS, Lim SH, Jung HC, Song IS. Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn\u2032s disease. J Gastroenterol Hepatol 2007;22:1032-8.","DOI":"10.1111\/j.1440-1746.2007.04927.x"},{"key":"ref=17","doi-asserted-by":"crossref","unstructured":"17. Spagnolo P, Sato H, Marshall SE, Antoniou KM, Ahmad T, Wells AU, et al. Association between heat shock protein 70\/Hom genetic polymorphisms and uveitis in patients with sarcoidosis. Invest Ophthalmol Vis Sci 2007;48:3019-25.","DOI":"10.1167\/iovs.06-1485"},{"key":"ref=18","doi-asserted-by":"crossref","unstructured":"18. Mir KA, Pugazhendhi S, Paul MJ, Nair A, Ramakrishna BS. Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. Br J Surg 2009;96:1205-9.","DOI":"10.1002\/bjs.6689"},{"key":"ref=19","doi-asserted-by":"crossref","unstructured":"19. Davis SM, Clark EA, Nelson LT, Silver RM. The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis. Am J Obstet Gynecol 2010;202:308.e1-8.","DOI":"10.1016\/j.ajog.2010.01.006"},{"key":"ref=20","doi-asserted-by":"crossref","unstructured":"20. Naffaa M, Makhoul BF, Tobia A, Kaplan M, Aronson D, Saliba W, et al. Interleukin-6 at discharge predicts all-cause mortality in patients with sepsis. Am J Emerg Med 2013;31:1361-4.","DOI":"10.1016\/j.ajem.2013.06.011"}],"container-title":["Indian Journal of Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ijccm.org\/doi\/pdf\/10.4103\/0972-5229.130571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T19:33:12Z","timestamp":1622143992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ijccm.org\/doi\/10.4103\/0972-5229.130571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014]]}},"alternative-id":["10.4103\/0972-5229.130571"],"URL":"https:\/\/doi.org\/10.4103\/0972-5229.130571","relation":{},"ISSN":["0972-5229","1998-359X"],"issn-type":[{"value":"0972-5229","type":"print"},{"value":"1998-359X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}