{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:09:47Z","timestamp":1787792987832,"version":"build-2784847793"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Background &amp; objectives:<\/jats:italic>\n                      Dengue is one of the most important arboviruses and public health problem associated with increasingly large outbreaks, especially in tropical countries such as Brazil. The state of Minas Gerais, in particular, has had high numbers of cases of this infection in recent years.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      Our study evaluated the epidemiological impact of dengue fever in the state of Minas Gerais from the National Health System (Sistema \u00danico de Sa\u00fade, SUS) perspective between 2000 to 2015 using the Brazilian Notifiable Diseases Information System (SINAN, notification cases) and Hospital Information System (SIH)\/SUS (hospitalization registers) databases.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      The SUS database recorded 34,996 reports of dengue (International Classification of Diseases [ICD]: A90) as well as 1984 verified cases of severe dengue (ICD-A91). These hospitalizations for dengue and cases of severe dengue generally affected individuals aged 15\u201324 (17.74%) and 5\u201314 (20.86%) years, respectively. The epidemiological burden of dengue was substantial in Minas Gerais state, with the highest number of notifications nationally in 2013.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Interpretation &amp; conclusion:<\/jats:italic>\n                      From retrospective data associated with dengue records, our study sought to better highlight the locations with the largest number of dengue cases in the Minas Gerais state, and contribute to direct educational and surveillance actions of these regions applied to this infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0972-9062.321738","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T05:57:43Z","timestamp":1637215063000},"page":"54-62","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Profile of hospitalization and death records associated to dengue and severe dengue in Minas Gerais between 2000 and 2015 from the Brazilian Public Health System perspective"],"prefix":"10.4103","volume":"58","author":[{"given":"Gabriel Henrique","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Rodrigues","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V\u00edtor Vieira","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Guimar\u00e3es","family":"Parreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Piassi Dias","family":"God\u00f3i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240830","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013","journal-title":"Nature"},{"key":"R2-8-20240830","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1080\/14760584.2018.1546581","article-title":"Economic and epidemiological impact of dengue illness over 16 years from a public health system perspective in Brazil to inform future health policies including the adoption of a dengue vaccine","volume":"17","author":"God\u00f3i","year":"2018","journal-title":"Expert Rev Vaccines"},{"key":"R5-8-20240830","doi-asserted-by":"crossref","first-page":"e1760","DOI":"10.1371\/journal.pntd.0001760","article-title":"Refining the global spatial limits of dengue virus transmission by evidence-based consensus","volume":"6","author":"Brady","year":"2012","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"R6-8-20240830","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10822-010-9326-8","article-title":"Design, structure-based focusing and in silico screening of combinatorial library of peptidomimetic inhibitors of dengue virus NS2B-NS3 protease","volume":"24","author":"Frecer","year":"2010","journal-title":"Journal of Computer-Aided Molecular Design"},{"key":"R7-8-20240830","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.2217\/fvl.13.95","article-title":"Direct feeding on dengue patients yields new insights into human to mosquito dengue virus transmission","volume":"8","author":"Forshey","year":"2013","journal-title":"Future Virology"},{"key":"R8-8-20240830","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5433\/2316-5200.2014v3n2p16","article-title":"NS2B-NS3pro as a Molecular Target Drugs Development against Dengue","volume":"3","author":"God\u00f3i","year":"2014","journal-title":"Biochemistry and biotechnology reports"},{"key":"R9-8-20240830","first-page":"1","article-title":"Docking and QM\/MM Studies of NS2B-NS3pro Inhibitors: a Molecular Target against the Dengue Virus","volume":"00","author":"God\u00f3i","year":"2016","journal-title":"Journal of the Brazilian Chemical Society"},{"key":"R10-8-20240830","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/1871526510909030327","article-title":"New approaches to structure-based discovery of dengue protease inhibitors","volume":"9","author":"Tomlinson","year":"2009","journal-title":"Infectious Disorders Drug Targets"},{"key":"R11-8-20240830","first-page":"83","article-title":"Aedes albopictus and the world trade in used tires, 1988\u20131995: the shape of things to come?","volume":"14","author":"Reiter","year":"1998","journal-title":"Journal of the American Mosquito Control Association"},{"key":"R12-8-20240830","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/vbz.2007.0280","article-title":"Dengue infection in neotropical forest mammals","volume":"9","author":"Thoisy","year":"2009","journal-title":"Vector and Borne Zoonotic Diseases"},{"key":"R13-8-20240830","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Current concepts dengue","volume":"366","author":"Simmons","year":"2012","journal-title":"The New England Journal of Medicine"},{"key":"R15-8-20240830","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1590\/1413-81232015204.00672014","article-title":"Completeness of tuberculosis reporting forms for disease control in individuals with HIV\/AIDS in priority cities of Bahia state","volume":"20","author":"L\u00edrio","year":"2015","journal-title":"Ci\u00eancia & Sa\u00fade Coletiva"},{"key":"R16-8-20240830","first-page":"171","article-title":"An evaluation of the Sinan health information system as used by the Hansen\u2019s disease control programme, Pernambuco state, Brazil","volume":"79","author":"Galv\u00e3o","year":"2008","journal-title":"Leprosy"},{"key":"R23-8-20240830","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/tmi.12425","article-title":"Factors associated with death from dengue in the state of Minas Gerais, Brazil: historical cohort study","volume":"20","author":"Campos","year":"2015","journal-title":"Tropical Medicine & International Health (TM & IH"},{"key":"R24-8-20240830","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1590\/S0034-89102006000100021","article-title":"Qualidade dos dados da vigil\u00e2ncia epidemiol\u00f3gica da dengue em Belo Horizonte, MG","volume":"40","author":"Duarte","year":"2006","journal-title":"Revista Sa\u00fade P\u00fablica"},{"key":"R25-8-20240830","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1590\/S0102-311X2010000300019","article-title":"Persist\u00eancia dos sintomas de dengue em uma popula\u00e7\u00e3o de Uberaba, Minas Gerais, Brasil","volume":"26","author":"Teixeira","year":"2010","journal-title":"Cadernos de Sa\u00fade P\u00fablica"},{"key":"R26-8-20240830","first-page":"217","article-title":"Fatores associados \u00e0 infec\u00e7\u00e3o pelo v\u00edrus do dengue no Munic\u00edpio de Belo Horizonte, Estado de Minas Gerais, Brasil: caracter\u00edsticas individuais e diferen\u00e7as intra-urbanas","volume":"17","author":"Cunha","year":"2008","journal-title":"Epidemiologia Servi\u00e7os de Sa\u00fade"},{"key":"R27-8-20240830","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.aprim.2013.12.016","article-title":"Spatial analysis of dengue and Primary Health Care in Alfenas, Minas Gerais, Brazil","volume":"46","author":"Nascimento","year":"2014","journal-title":"Atenci\u00f3n Primaria"},{"key":"R30-8-20240830","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2217\/cer-2016-0045","article-title":"CYD-TDV dengue vaccine: systematic review and meta-analysis of efficacy, immunogenicity and safety","volume":"6","author":"God\u00f3i","year":"2017","journal-title":"Journal of Comparative effectiveness research"},{"key":"R38-8-20240830","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1590\/S0037-86822007000200009","article-title":"Estudo retrospectivo (hist\u00f3rico) da dengue no Brasil: caracter\u00edsticas regionais e din\u00e2micas","volume":"40","author":"C\u00e2mara","year":"2007","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"R39-8-20240830","first-page":"50","article-title":"A sala de situa\u00e7\u00e3o da dengue como ferramenta de gest\u00e3o em sa\u00fade","volume":"38","author":"Deininger","year":"2014","journal-title":"Sa\u00fade em Debate"},{"key":"R40-8-20240830","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1590\/S0102-86502005000800002","article-title":"Desenhos de pesquisa","volume":"20","author":"Hochman","year":"2005","journal-title":"Acta Cir\u00fargica Brasileira"},{"key":"R45-8-20240830","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1590\/S1415-790X2002000200006","article-title":"Avalia\u00e7\u00e3o de diferentes estrat\u00e9gias de blocagem no relacionamento probabil\u00edstico de registros","volume":"5","author":"Coeli","year":"2002","journal-title":"Revista Brasileira de Epidemiologia"},{"key":"R46-8-20240830","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/S0102-30982007000100010","article-title":"A constru\u00e7\u00e3o da base de dados nacional em terapia renal substitutiva (TRS) centrada no indiv\u00edduo: aplica\u00e7\u00e3o do m\u00e9todo de linkage determin\u00edstico-probabil\u00edstico","volume":"24","author":"Cherchiglia","year":"2007","journal-title":"Revista Brasileira de Estudos de Popula\u00e7\u00e3o"},{"key":"R47-8-20240830","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1590\/S0102-311X2010000100017","article-title":"Cyclosporine versus tacrolimus in kidney transplants in Brazil: a cost comparison","volume":"26","author":"Guerra J\u00fanior","year":"2010","journal-title":"Cadernos de Sa\u00fade P"},{"key":"R48-8-20240830","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1590\/S0102-30982009000200007","article-title":"Perfil demogr\u00e1fico e epidemiol\u00f3gico dos usu\u00e1rios de medicamentos de alto custo no Sistema \u00danico de Sa\u00fade","volume":"26","author":"Ac\u00farcio","year":"2009","journal-title":"Revista Brasileira de Estudos de Popula\u00e7\u00e3o"},{"key":"R49-8-20240830","doi-asserted-by":"crossref","first-page":"75","DOI":"10.32749\/nucleodoconhecimento.com.br\/saude\/perfil-soro-epidemiologico-dengue","article-title":"Perfil Soro Epidemiol\u00f3gico dos casos de dengue notificados no munic\u00edpio de Bel\u00e9m\/Par\u00e1","volume":"1","author":"Silva","year":"2016","journal-title":"Revista Cient\u00edfica Multidisciplinar N\u00facleo do Conhecimento"},{"key":"R50-8-20240830","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5123\/S1679-49742013000100007","article-title":"Diferen\u00e7as, segundo faixa et\u00e1ria, do perfil cl\u00ednico epidemiol\u00f3gico dos casos de dengue grave atendicdos no Hospital Federal dos Servidores do Estado, Rio de Janeiro- RJ, Brasil, durante a epidemia de 2008","volume":"22","author":"Escosteguy","year":"2013","journal-title":"Epidemiologia e Servi\u00e7os de Sa\u00fade"},{"key":"R53-8-20240830","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1590\/S0102-311X2004000600002","article-title":"Preven\u00e7\u00e3o e controle do dengue: uma revis\u00e3o de estudos sobre conhecimentos, cren\u00e7as e pr\u00e1ticas da popula\u00e7\u00e3o","volume":"20","author":"Claro","year":"2004","journal-title":"Cadernos de sa\u00fade p\u00fablica"},{"key":"R54-8-20240830","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2009.11.009","article-title":"Structure and functionality in flavivirus NS-proteins: perspectives for drug design","volume":"87","author":"Bollati","year":"2010","journal-title":"Antiviral Research"},{"key":"R55-8-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2008.197","article-title":"Protein structure homology modeling using SWISS-MODEL workspace","volume":"4","author":"Bordoli","year":"2009","journal-title":"Nature Protocols"},{"key":"R56-8-20240830","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/157340908786786047","article-title":"WF. Virtual screening of drugs: Score functions, docking, and drug design","volume":"4","author":"Breda","year":"2008","journal-title":"Current Computer-Aided Drug Designs"},{"key":"R57-8-20240830","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nrd1549","article-title":"Docking and scoring in virtual screening for drug discovery: methods and applications","volume":"3","author":"Kitchen","year":"2004","journal-title":"Nature Reviews Drug Discovery"},{"key":"R58-8-20240830","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"Journal of Computational Chemistry"},{"key":"R59-8-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157341208783497597","article-title":"Protein\u2013ligand docking: a review of recent advances and future perspectives","volume":"4","author":"Pujadas","year":"2008","journal-title":"Current Pharmaceutical Analysis"},{"key":"R60-8-20240830","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.drudis.2009.02.008","article-title":"Medicinal chemistry strategies in follow-on drug discovery","volume":"14","author":"Zhao","year":"2009","journal-title":"Drug Discovery Today"},{"key":"R61-8-20240830","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10822-016-9900-9","article-title":"1001 Ways to run AutoDock Vina for virtual screening","volume":"30","author":"Jaghoori","year":"2016","journal-title":"Journal of Computer Aided Molecular Design"},{"key":"R62-8-20240830","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1570180812666150918191550","article-title":"Flexibility in the Molecular Design of Acetylcholinesterase Reactivators: Probing Representative Conformations by Chemometric Techniques and Docking\/QM Calculations","volume":"13","author":"Lima","year":"2016","journal-title":"Letters in Drug Design & Discovery"},{"key":"R63-8-20240830","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jmgm.2015.05.008","article-title":"Binding specificity of polypeptide substrates in NS2B\/NS3pro serine protease of dengue virus type 2: A molecular dynamics Study","volume":"60","author":"Yotmanee","year":"2015","journal-title":"Journal of Molecular Graphics & Modelling"},{"key":"R64-8-20240830","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jmgm.2008.05.002","article-title":"QM\/QM studies for Michael reaction in coronavirus main protease (3CL Pro)","volume":"27","author":"Taranto","year":"2008","journal-title":"Journal of Molecular Graphics & Modelling"},{"key":"R65-8-20240830","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1002\/qua.24102","article-title":"Comparative modeling and QM\/MM studies of cysteine protease mutant of Theobroma cacao","volume":"112","author":"Andrade","year":"2012","journal-title":"International Journal Quantum Chemistry"},{"key":"R66-8-20240830","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00214-006-0143-z","article-title":"QM\/MM: what have we learned, where are we, and where do we go from here?","volume":"117","author":"Lin","year":"2007","journal-title":"Theoretical Chemistry Accounts"},{"key":"R67-8-20240830","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/jcc.540110605","article-title":"A combined quantum mechanical and molecular mechanical potential for molecular dynamics simulations","volume":"11","author":"Field","year":"1990","journal-title":"Journal of Computational Chemistry"},{"key":"R68-8-20240830","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Research"},{"key":"R69-8-20240830","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2174\/157340908786786047","article-title":"Virtual screening of drugs: score functions, docking, and drug design","volume":"4","author":"Breda","year":"2008","journal-title":"Current Computer Aided Drug Design"}],"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.321738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:45Z","timestamp":1787166825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.321738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/0972-9062.321738","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}