{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:19:47Z","timestamp":1787761187478,"version":"build-2784847793"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Background &amp; objectives:<\/jats:italic>\n                      For decades, the city of Bel\u00e9m in Brazil\u2019s eastern Amazon was the second city in the country with highest prevalence of cases of filariasis due to\n                      <jats:italic toggle=\"yes\">Wuchereria bancrofti<\/jats:italic>\n                      infection. However, this prevalence decreased over time until reaching null records, concomitantly with a decrease in frequency of recorded hydrocele cases. In this context, we analyzed cross-sectional data to evaluate the degree of correlation between prevalence of positive blood microfilariae results during surveillance screening occurred along 54 years (1951\u20132005) and prevalence of hydrocele cases recorded in the same time period.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                      The dataset regarding hydrocele cases was obtained from two local hospitals. The Endemic Diseases Control Division of the Health Surveillance Department of the Municipal Health Department of Bel\u00e9m provided dataset regarding positive blood microfilariae cases. Prevalence calculus and linear correlation statistics were performed.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                      Both positive blood microfilariae and hydrocele cases are well correlated statistically in absolute frequency (r = 0.871, 95%\n                      <jats:sub>CI<\/jats:sub>\n                      = 0.788 to 0.923, R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.759,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001) and in prevalence (r = 0.835, 95%\n                      <jats:sub>CI<\/jats:sub>\n                      = 0.732 to 0.901, R\n                      <jats:sup>2<\/jats:sup>\n                      = 0.698,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Interpretation &amp; conclusion:<\/jats:italic>\n                      We have concluded that blood microfilariae detection and hospitalized hydrocele cases are well correlated in our dataset. In addition, these results support the hypothesis that hydrocele prevalence can be useful to filariasis surveillance and control in endemic areas. However, limitations to hydrocele prevalence as an epidemiological indicator of filariasis are evidenced.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0972-9062.321756","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T01:17:15Z","timestamp":1671585435000},"page":"240-245","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Correlated prevalence of hydrocele and microfilaremia in Amazon (Bel\u00e9m, 1951-2005)"],"prefix":"10.4103","volume":"58","author":[{"given":"Dilma Costa","family":"de Oliveira Neves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Fraiha-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"de Nazar\u00e9 Martins da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara L\u00facia","family":"Lins Jennings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Martins da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Nice","family":"Sodr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Eduardo","family":"Corr\u00eaa Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20240830","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0169-4758(00)01778-6","article-title":"Pathogenesis of lymphatic 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Clinical and parasitological investigations in Mambrui a small coastal town and Jaribuni a rural area","volume":"71","author":"Wijers","year":"1977","journal-title":"Ann Trop Med Parasitol"},{"key":"R21-9-20240830","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0035-9203(89)90511-7","article-title":"Microfilaraemia, serum antibody and development of clinical disease in microfilaraemic subjects infected with Wuchereria bancrofti and treated with Diethylcarbamazine citrate","volume":"83","author":"Dissanayake","year":"1989","journal-title":"Trans R Soc Trop Med"},{"key":"R22-9-20240830","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/00034983.1995.11813000","article-title":"A 16 year follow-up study on bancroftian filariasis in three communities of north-eastern Tanzania","volume":"89","author":"Meyrowitsh","year":"1995","journal-title":"Ann Trop Med Parasitol"},{"key":"R23-9-20240830","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/00034983.1995.11812999","article-title":"Bancroftian filariasis: analysis of infection and disease in five endemic communities of north eastern Tanzania","volume":"89","author":"Meyrowitsh","year":"1995","journal-title":"Ann Trop Med Parasitol"},{"key":"R25-9-20240830","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0035-9203(91)90048-4","article-title":"Clinical epidemiology of bancroftian filariasis: effect of age and gender","volume":"85","author":"Pani","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R26-9-20240830","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.trstmh.2006.09.006","article-title":"Chronic clinical manifestations related to Wuchereria bancrofti infection in a highly endemic area in Kenya","volume":"101","author":"Njenga","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R27-9-20240830","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/00034983.1979.11687298","article-title":"Bancroftian filariasis and other parasitic infections in the Middle Fly River region of Western Papua New Guinea; Clinical parasitological and serological studies","volume":"73","author":"Knight","year":"1979","journal-title":"Ann Trop Med Parasitol"},{"key":"R28-9-20240830","first-page":"609","article-title":"Epidemiology and control of bancroftian filariasis in Ceylon","volume":"36","author":"Abdulcader","year":"1966","journal-title":"Japan J Exp Med"},{"key":"R29-9-20240830","first-page":"259","article-title":"Clinical manifestations of Wuchereria bancrofti filariasis in an endemic village in the Nile Delta","volume":"67","author":"Feinsod","year":"1987","journal-title":"Ann Soc Belge Med"},{"key":"R30-9-20240830","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0035-9203(88)90214-3","article-title":"Epidemiology of Wuchereria bancrofti in Leogane Haiti","volume":"82","author":"Raccurt","year":"1988","journal-title":"Trans R Soc Trop Med"},{"key":"R31-9-20240830","first-page":"1","article-title":"Situa\u00e7\u00e3o epidemiol\u00f3gica e estrat\u00e9gias de preven\u00e7\u00e3o, controle e elimina\u00e7\u00e3o das doen\u00e7as tropicais negligenciadas no Brasil, 1995 a 2016","volume":"49","author":"Sa\u00fade","year":"2018","journal-title":"Boletim Epidemiol\u00f3gico"}],"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.321756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:26:37Z","timestamp":1787757997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.321756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/0972-9062.321756","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]}}}