{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:04Z","timestamp":1787761204120,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"\n \n \n Background & objectives:<\/jats:italic>\n Presence of dengue is reported from India since 1960s. Secondary dengue infection may be more severe than primary, hence, distinction between primary and secondary dengue is essential. A way to detect secondary dengue is demonstration of anti DV IgG in patients\u2019 serum. In this study we explored the association of dengue severity with anti DV IgG positivity.\n <\/jats:p>\n \n Methods:<\/jats:italic>\n Laboratory confirmed cases of dengue (positive for anti DV IgM\/ NS-1 Antigen\/ DV \u2013RNA), presenting to the hospital within 7 days of illness, were consecutively enrolled for a period of one month (September 1\u201330, 2018) and were tested for anti DV IgG in their serum. All PCR positive samples were serotyped. Cases positive for anti-dengue IgG were labeled as secondary cases. Clinical details were collected to assess the severity of illness. Association of dengue severity with anti DV IgG positivity was calculated.\n <\/jats:p>\n \n Results:<\/jats:italic>\n Of the 128 dengue positive cases, 89 (69.5%) were anti DV IgM positive, 72 (56.3%) were Dengue NS-1 positives and 37 (28.9%) were DV-RNA positive. Only 39 (30.5%) cases were having detectable anti-dengue IgG in their serum (secondary dengue). Anti-dengue IgM positivity was significantly higher in secondary dengue cases. No association of anti DV IgG positivity was seen with severity of dengue illness.\n <\/jats:p>\n \n Interpretation & conclusion:<\/jats:italic>\n No association of IgG positivity with severity of illness was seen. D4 serotype is first time reported from Uttar Pradesh, India\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0972-9062.325637","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T01:17:15Z","timestamp":1671585435000},"page":"228-231","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Severity of dengue illness and presence of anti DV IgG in serum of laboratory confirmed dengue cases"],"prefix":"10.4103","volume":"58","author":[{"given":"Amita","family":"Jain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish Nasar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suruchi","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240830","first-page":"70","article-title":"Eventual role of asymptomatic cases of dengue for the introduction and spread of dengue viruses in non-endemic regions. 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