{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:37Z","timestamp":1787169877764,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; objectives:<\/jats:title>\n                    <jats:p>\n                      In neuroborreliosis (NB) serology might objectively differentiate ongoing from past infection when the intrathecal space is involved. The hierarchy of the parallel serum-CSF (cerebrospinal fluid) methods is seldom discussed and remains elusive in daily practice. We compared the efficacy of certain methods and assessed the prevalence of anti-\n                      <jats:italic toggle=\"yes\">Borrelia<\/jats:italic>\n                      antibodies in the local population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We summarized standard two-tier test results in all ELISA-reactive samples of patients with suspected NB (n=152) since 2017 and tested 122 unrelated sera for anti-\n                      <jats:italic toggle=\"yes\">Borrelia<\/jats:italic>\n                      antibodies from central Hungary.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The most common central nervous system symptom was a cranial nerve palsy (27.6% of all subjects). CSF was available in 25 cases. A serum-CSF IgG-matched line immunoassay (LIA) detected intrathecal antibody production correctly in 6 of 8 samples when compared to the ELISA-based antibody-index (AI). Among the 122 random sera the prevalence of specific anti-\n                      <jats:italic toggle=\"yes\">Borrelia<\/jats:italic>\n                      IgG antibodies (on LIA, not including anti-p41) were 6.8% above 30 and 10% above 60 years. Our results enable us to assume the predictive values of serological results according to the pretest probability of neuroborreliosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation &amp; conclusion:<\/jats:title>\n                    <jats:p>Our results suggest that recombinant antigen-based two-tier serology from solely the sera might have sufficient positive predictive value to verify NB in young individuals with characteristic anamnestic data in our region. When parallel serum-CSF testing is warranted, AI should have priority. IgG and albumin concentrations in both the serum and the CSF, the potential time of exposure and the nature and duration of symptoms form the bare minimal set of data for conclusive testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0972-9062.374040","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T10:01:41Z","timestamp":1681120901000},"page":"365-371","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis of neuroborreliosis in the context of local seroprevalence: A chart review study and a methodological overview"],"prefix":"10.4103","volume":"60","author":[{"given":"Andr\u00e1s","family":"Bar\u00e1th","sequence":"first","affiliation":[{"name":"South-west Central Hospital, National Institute of Haematology and Infectology, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"R\u00e9v\u00e9sz","sequence":"additional","affiliation":[{"name":"National Institute of Oncology, Multidisciplinary Head and Neck Cancer Center, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"G\u00f6nczi","sequence":"additional","affiliation":[{"name":"South-west Central Hospital, National Institute of Haematology and Infectology, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Bek\u0151","sequence":"additional","affiliation":[{"name":"South-west Central Hospital, National Institute of Haematology and Infectology, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Z\u00f3ka","sequence":"additional","affiliation":[{"name":"South-west Central Hospital, National Institute of Haematology and Infectology, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"issue":"2","key":"R1-20240830","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.medmal.2018.11.011","article-title":"Review of European and American guidelines for the diagnosis of Lyme borreliosis","volume":"49","author":"Eldin","year":"2019","journal-title":"M\u00e9decine Mal Infect"},{"issue":"4","key":"R2-20240830","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/10408363.2018.1450353","article-title":"Laboratory diagnosis of Lyme borreliosis: Current state of the art and future perspectives","volume":"55","author":"Lohr","year":"2018","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"1","key":"R3-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood\u2013brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"3","key":"R4-20240830","doi-asserted-by":"crossref","first-page":"e001403","DOI":"10.1136\/rmdopen-2020-001403","article-title":"Incidence of facial nerve palsies stratified by DMARD treatment in patients with rheumatoid arthritis: data from the RABBIT register","volume":"6","author":"Meissner","year":"2020","journal-title":"RMD Open"},{"key":"R5-20240830","article-title":"Neurologic Lyme disease | CDC. 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