{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:34:43Z","timestamp":1787070883703,"version":"build-2736575974"},"reference-count":4,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    Lyme disease (LD) and tick-bome relapsing fever (TBRF), both consequences of\n                    <jats:italic toggle=\"yes\">Borrelia burgdorferi<\/jats:italic>\n                    infection, pose significant public health threats with overlapping symptomatic presentations. A previous study explores the potential of line immunoblots (IBs) as a transformative diagnostic tool for distinguishing between LD and TBRF. By employing strategically designed recombinant proteins on nitrocellulose membrane strips, IBs offer enhanced accuracy in identifying antibodies in patient samples. While serological assays for LD have seen advancements, the diagnostic landscape for TBRF lags behind, necessitating comprehensive diagnostic approaches capable of addressing both conditions. Immunoblots, with their ability to detect antibodies with exceptional precision, not only facilitate accurate diagnosis but also enable tailored patient treatment and monitoring of treatment response. The study underscores the importance of immunoblots in improving diagnostic accuracy and patient outcomes for tick- borne diseases. In conclusion, as research progresses in understanding LD and TBRF, immunoblots emerge not only as diagnostic tool but also as valuable resources for advancing research and refining patient treatment strategies.\n                  <\/jats:p>","DOI":"10.4103\/0972-9062.383642","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T12:09:54Z","timestamp":1711454994000},"page":"630-631","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The crucial role of immunoblots in distinguishing Lyme disease from tick-borne relapsing fever"],"prefix":"10.4103","volume":"61","author":[{"given":"Zahra Ali","family":"Haque","sequence":"first","affiliation":[{"name":"Islamic International Medical College, Riphah International University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Aqib Farooq","family":"Khan","sequence":"additional","affiliation":[{"name":"Islamic International Medical College, Riphah International University, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnoor","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Foundation University Medical College, Islamabad, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"R1-20241128","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10393-024-01676-9","article-title":"By-degree Health and Economic Impacts of Lyme Disease, Eastern and Midwestern United States","volume":"21","author":"Yang","year":"2024","journal-title":"Ecohealth"},{"issue":"4","key":"R2-20241128","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4103\/0972-9062.383641","article-title":"Recombinant protein immunoblots for differential diagnosis of tick-bome relapsing fever and Lyme disease","volume":"60","author":"Shah","year":"2023","journal-title":"J Vector Borne Dis"},{"issue":"4","key":"R3-20241128","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3390\/healthcare7040121","article-title":"Line Immunoblot Assay for Tick-Borne Relapsing Fever and Findings in Patient Sera from Australia, Ukraine and the USA","volume":"7","author":"Shah","year":"2019","journal-title":"Healthcare"},{"issue":"2","key":"R4-20241128","article-title":"Laboratory Diagnosis of Lyme Borreliosis","volume":"34","author":"Branda","year":"2021","journal-title":"Clin Microbio l Rev"}],"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.383642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:12Z","timestamp":1787067492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.383642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/0972-9062.383642","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-03-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}