{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:27:04Z","timestamp":1787776024503,"version":"build-2784847793"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; objectives:<\/jats:title>\n                    <jats:p>\n                      The correct association between\n                      <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                      parasite density and the cellular constituents of blood is not known in entirety in Nigerian children. Thus, we decided to study the association between cellular blood constituents and malaria parasite density in malaria infected children attending a Nigerian hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A study of all children diagnosed with malaria fever at the Pediatric out-patient clinic, Cedar Crest Hospital, Abuja, Nigeria, was conducted. Packed cell volume, white blood cells with differentials and platelet counts and malaria parasite densities obtained from blood samples were studied. Malaria parasite densities more than 2 pluses were classified as significant parasitemia and 1 plus as non-significant. Information obtained was recorded and analysed with SPSS 22 software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total 143 children (74 boys and 69 girls) diagnosed with malaria of ages between 5 months to 17 years (mean 5.24 \u00b14.60) were studied. The majority of 141 (98.6%) had non-significant\n                      <jats:italic toggle=\"yes\">P. falciparum<\/jats:italic>\n                      parasitemia, while 2 (2.4%) had significant parasitemia. Of the 143 children with malaria, 116 (81.1%) had a normal leucocyte count. All children with significant parasitemia had a normal leucocyte count. Of the 143 children, 11 (7.7%) had anemia and 10 (7.0%) thrombocytopenia. Anemia, monocytosis and thrombocytopenia were significantly associated with significant malaria parasitemia (p&lt;0.05). Mean platelet counts was significantly less amongst those with significant parasitemia (p&lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation &amp; conclusion:<\/jats:title>\n                    <jats:p>All patients with significant malaria parasitemia had normal leucocyte count. Significant malaria parasitemia is significantly associated with anemia, thrombocytopenia and monocytosis. Blood film appearances showing these changes are suggestive of significant malaria parasitemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0972-9062.393971","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:08Z","timestamp":1705622408000},"page":"364-368","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Association between malaria parasite density and hematological profile in malaria infected children at a Nigerian Private hospital"],"prefix":"10.4103","volume":"61","author":[{"given":"Oyedeji Olusola","family":"Adetunji","sequence":"first","affiliation":[{"name":"Wesley Guild Hospital, Ilesa, Osun State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"issue":"9","key":"R1-20240921","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.medcli.2020.05.010","article-title":"Update on malaria","volume":"155","author":"Varo","year":"2022","journal-title":"Med Clin Bare"},{"issue":"3","key":"R2-20240921","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1010539515583388","article-title":"Malaria continues as a major public health problem","volume":"27","author":"Binns","year":"2015","journal-title":"Asia Pac J Public Health"},{"issue":"3","key":"R3-20240921","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/ije\/dyl027","article-title":"The burden of malaria mortality among African children in the year 2000","volume":"55","author":"Rowe","year":"2006","journal-title":"Int J Epidemiol"},{"issue":"1","key":"R4-20240921","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12936-018-2509-9","article-title":"Anaemia and malaria","volume":"17","author":"White","year":"2018","journal-title":"Malar J"},{"issue":"3","key":"R5-20240921","doi-asserted-by":"crossref","first-page":"e0121057","DOI":"10.1371\/journal.pone.0121057","article-title":"Effects of malaria parasite density on blood cell parameters","volume":"10","author":"Kotepui","year":"2015","journal-title":"PLoS One"},{"key":"R6-20240921","first-page":"3814513","article-title":"Assessment of Hematological Parameters in Malaria, among Adult Patients Attending the Bamenda Regional Hospital","volume":"2020","author":"Omarine","year":"2020","journal-title":"Anemia"},{"key":"R7-20240921","doi-asserted-by":"crossref","first-page":"5954394","DOI":"10.1155\/2016\/5954394","article-title":"Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen","volume":"2016","author":"Al-Salahy","year":"2016","journal-title":"Interdiscip Perspect Infect Dis"},{"issue":"6","key":"R12-20240921","first-page":"362","article-title":"Parasite density and the spectrum of clinical illness in falciparum malaria","volume":"18","author":"Ali","year":"2008","journal-title":"J Coll Physicians Surg Pak"},{"issue":"4","key":"R13-20240921","first-page":"266","article-title":"Age as a risk factor for thrombocytopenia and anaemia in children treated for acute uncomplicated falciparum malaria","volume":"44","author":"Adedapo","year":"2007","journal-title":"J Vector Borne Dis"},{"issue":"3","key":"R14-20240921","first-page":"274","article-title":"Predictors of Bacterial Co-Infection and Outcome in Children with Severe Malaria in Ilorin, Nigeria","volume":"38","author":"Ojuawo","year":"2021","journal-title":"West Afr J Med"},{"key":"R15-20240921","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2147\/JBM.S378133","article-title":"Impact of Abnormal Leukocyte Count in the Pathophysiology of Sickle Cell Anemia","volume":"13","author":"Yousif","year":"2022","journal-title":"J Blood Med"},{"issue":"5","key":"R16-20240921","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10245332.2000.11746536","article-title":"The Role of Inflammation and Leukocytes in the Pathogenesis of Sickle Cell Disease; Haemoglobinopathy","volume":"5","author":"Wun","year":"2001","journal-title":"Hematology"},{"issue":"8b","key":"R17-20240921","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.7196\/SAMJ.2019.v109i8b.13829","article-title":"HIV and haematopoiesis","volume":"109","author":"Durandt","year":"2019","journal-title":"S Afr Med J"},{"issue":"9","key":"R18-20240921","doi-asserted-by":"crossref","first-page":"e0257630","DOI":"10.1371\/journal.pone.0257630","article-title":"The prevalence of thrombocytopenia and leucopenia among people living with HIV\/AIDS in Ethiopia: A systematic review and meta-analysis","volume":"16","author":"Bisetegn","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"R19-20240921","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12830","article-title":"Innate immunity to malariaThe role of monocytes","volume":"293","author":"Dobbs","year":"2020","journal-title":"Immunol Rev"},{"key":"R20-20240921","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.3389\/fimmu.2018.02888","article-title":"The Rough Guide to Monocytes in Malaria Infection","volume":"9","author":"Ortega-Pajares","year":"2018","journal-title":"Front Immunol"},{"issue":"3","key":"R21-20240921","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/tropej\/fmm002","article-title":"Increasing burden of childhood severe malaria in a Nigerian tertiary hospital: implication for control","volume":"53","author":"Orimadegun","year":"2007","journal-title":"J Trop Pediatr"},{"issue":"3","key":"R22-20240921","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4314\/eamj.v78i3.9078","article-title":"Malaria in children in Ilorin, Nigeria","volume":"78","author":"Olanrewaju","year":"2001","journal-title":"East Afr Med J"},{"issue":"3","key":"R23-20240921","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4314\/eamj.v78i3.9078","article-title":"Malaria in children in Ilorin, Nigeria","volume":"78","author":"Olanrewaju","year":"2001","journal-title":"East Afr Med J"},{"issue":"9","key":"R24-20240921","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.7150\/ijbs.7.1427","article-title":"Severe malarial anemia: innate immunity and pathogenesis","volume":"7","author":"Perkins","year":"2011","journal-title":"Int J Biol Sci"},{"issue":"1","key":"R25-20240921","first-page":"143","article-title":"Platelet count in malaria patients","volume":"23","author":"Shaikh","year":"2011","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"1","key":"R26-20240921","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4103\/1117-1936.175229","article-title":"Effect of acute uncomplicated malaria on platelet counts","volume":"12","author":"Kehinde","year":"2005","journal-title":"Niger Postgrad Med J"},{"issue":"6","key":"R27-20240921","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/tropej\/fmp028","article-title":"Coagulation status and platelet functions in children with severe falciparum malaria and their correlation of outcome","volume":"55","author":"Prasad","year":"2009","journal-title":"J Trop Pediatr"}],"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.393971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:47:08Z","timestamp":1787773628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/0972-9062.393971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/0972-9062.393971","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-08-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}