{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:25Z","timestamp":1787071285983,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hereditary ectodermal dysplasia is a genetic recessive trait characterized by hypohydrosis, hypotrichosis, and hypodontia. The affected individual show characteristic physiognomy like protruded forehead, depressed nasal bridge, periorbital wrinkling, protruded lips, etc. There is marked decrease in sweat and salivary secretion. Due to skin involvement palm and sole ridge patterns are disrupted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>In this study an attempt has been made to classify the affected members according to the degree of penetrance by pedigree analysis and also study karyotyping for cytogenetics, dermatoglyphic analysis for the various ridge patterns and variations in the number of sweat glands by sweat pore analysis in affected individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of five families who were affected with ectodermal dysplasia were considered. Pedigree analysis was drawn up to three generation by obtaining history. Dermatoglyphics and sweat pore analysis was done by obtaining palm and finger print impression using stamp pad ink. Karyotyping was done by collecting 3\u20135 ml peripheral blood. Karyotyping was prepared using lymphocyte culture. Chromosomes were examined at 20 spreads selected randomly under \u00d7100 magnification. Results were analyzed by calculating mean values and percentage was obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Karyotyping did not show any abnormalities, dermatoglyphic analysis and sweat pore counts showed marked variations when compared with normal. Moreover, pedigree analysis confirmed the status of the disease as that of the recessive trait.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Large number of affected patients needs to be evaluated for dermatoglypic analysis. Genetic aspect of the disease needs to be looked into the molecular level in an attempt to locate the gene locus responsible for ectodermal dysplasia and its manifestation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-029x.102491","type":"journal-article","created":{"date-parts":[[2012,10,16]],"date-time":"2012-10-16T03:43:20Z","timestamp":1350359000000},"page":"380-387","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Karyotyping, dermatoglyphic, and sweat pore analysis of five families affected with ectodermal dysplasia"],"prefix":"10.4103","volume":"16","author":[{"given":"Manpreet","family":"Sidhu","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka D","family":"Kale","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences and Hospital, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayalakshmi S","family":"Kotrashetti","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Maratha Mandal's NGH Institute of Dental Sciences and Research Centre, Belgaum, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250922","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jmg.28.3.181","article-title":"Clinical and radiographic dental finding in X-linked hypohydrotic ectodermal dysplasia","volume":"28","author":"Crawford","year":"1991","journal-title":"J Med Genet"},{"key":"R2-20250922","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1136\/adc.62.10.989","article-title":"Clinical aspects of X-linked 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autosomal recessive inheritance","volume":"78","author":"Crump","year":"1971","journal-title":"J of Pedia"},{"key":"R15-20250922","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00006534-196944040-00018","article-title":"Congenital ectodermal dysplasia, anhidrotic with palatal paralysis and associated chromosome abnormality","volume":"44","author":"Wesser","year":"1969","journal-title":"Plast Reconst Surg"}],"container-title":["Journal of Oral and Maxillofacial 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