{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:26:14Z","timestamp":1787757974197,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>\n                    Neurofibromatosis-1 (NF-1) is a relatively common autosomal dominant disease characterized by multiple cutaneous fibromatoses and caf\u00e9 au lait spots. It is associated with the mutation of\n                    <jats:italic toggle=\"yes\">NF-1<\/jats:italic>\n                    gene, a tumor suppressor gene located on chromosome 17q11.2. Hence, it can be considered as a familial cancer predisposition syndrome in which the affected individuals are at increased risk of developing malignancies. Intraoral neurofibromas associated with NF-1 are quite common, but the occurrence of malignant peripheral nerve sheath tumor (MPNST) in the oral cavity is very rare. Oral MPNST can occur either\n                    <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                    or by malignant transformation of neurofibromas or very rarely can represent a metastatic lesion. Here, we present a case of MPNST involving the maxillary region, in a patient with NF-1. Since MPNST often creates a diagnostic dilemma, histopathologic criteria for the diagnosis of MPNST are also discussed.\n                  <\/jats:p>","DOI":"10.4103\/0973-029x.80025","type":"journal-article","created":{"date-parts":[[2011,4,26]],"date-time":"2011-04-26T02:43:10Z","timestamp":1303785790000},"page":"46-51","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Intraoral presentation of multiple malignant peripheral nerve sheath tumors associated with neurofibromatosis-1"],"prefix":"10.4103","volume":"15","author":[{"given":"Mahija","family":"Janardhanan","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Amrita School of Dentistry, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Rakesh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Amrita School of Dentistry, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RB","family":"Vinod Kumar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Amrita School of Dentistry, Kochi, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260605","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Genet"},{"key":"R2-20260605","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0030-4220(84)90350-5","article-title":"Neurofibromatosis: Oral and radiographic manifestations","volume":"58","author":"Shapiro","year":"1984","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R7-20260605","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/0970-9290.30917","article-title":"Malignant peripheral nerve sheath tumour: An elusive diagnosis","volume":"18","author":"Patel","year":"2007","journal-title":"Indian J Dent Res"},{"key":"R8-20260605","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1073\/pnas.87.14.5435","article-title":"Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen\u2019s neurofibromatosis","volume":"87","author":"Menon","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"R9-20260605","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/1097-0142(19860515)57:10<2006::AID-CNCR2820571022>3.0.CO;2-6","article-title":"Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases","volume":"57","author":"Ducatman","year":"1986","journal-title":"Cancer"},{"key":"R10-20260605","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/jso.2930250410","article-title":"Malignant soft tissue tumors of nerve sheath origin","volume":"25","author":"Nambisan","year":"1984","journal-title":"J Surg Oncol"},{"key":"R11-20260605","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1177\/014556130608500620","article-title":"Malignant peripheral nerve sheath tumors of the head and neck: Two cases and a review of the literature","volume":"85","author":"Martinez Devesa","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"R14-20260605","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/1097-0142(19810515)47:10<2503::AID-CNCR2820471033>3.0.CO;2-3","article-title":"(1981).Malignant schwannoma-clinical characteristics, survival, and response to therapy","volume":"47","author":"Sordillo","year":"1981","journal-title":"Cancer"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01233803-201115010-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:00:20Z","timestamp":1787756420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01233803-201115010-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-029x.80025","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}