{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:33:49Z","timestamp":1789814029345,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Oral lichen planus (OLP) is a chronic inflammatory disease that affects the mucus membrane of the oral cavity. It is a T-cell mediated autoimmune disease in which the cytotoxic CD8+ T cells trigger apoptosis of the basal cells of the oral epithelium. Several antigen-specific and nonspecific inflammatory mechanisms have been put forward to explain the accumulation and homing of CD8+ T cells subepithelially and the subsequent keratinocyte apoptosis. A wide spectrum of treatment modalities is available, from topical corticosteroids to laser ablation of the lesion. In this review, we discuss the various concepts in the pathogenesis and current treatment modalities of OLP.<\/jats:p>","DOI":"10.4103\/0973-029x.84474","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T01:14:57Z","timestamp":1315185297000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":251,"title":["Oral lichen planus: An update on pathogenesis and treatment"],"prefix":"10.4103","volume":"15","author":[{"given":"N","family":"Lavanya","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Jayanthi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umadevi K","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/154411130201300405","article-title":"The pathogenesis of oral lichen planus","volume":"13","author":"Sugerman","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0030-4220(86)90422-6","article-title":"Leukoplakia, lichen planus, and other oral keratoses in 23,616 white Americans over the age of 35 years","volume":"61","author":"Bouquot","year":"1986","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/10454411980090010501","article-title":"Update on oral lichen planus:etiopathogenesis and management","volume":"9","author":"Scully","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2334\/josnusd.49.89","article-title":"Oral lichen planus and Lichenoid reactions; Etiopathogenesis, diagnosis, management and malignant transformation","volume":"49","author":"Ismail","year":"2007","journal-title":"J Oral Sci"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S1085-5629(97)80018-1","article-title":"Immunopathogenesis of oral lichen planus and recurrent aphthous stomatitis","volume":"16","author":"Eversole","year":"1997","journal-title":"Semin Cutan Med Surg"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.0904-2512.2001.10063.x","article-title":"Intra-epithelial CD8+ T cells and basement membrane disruption in oral lichen planus","volume":"31","author":"Zhou","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S1079-2104(96)80074-6","article-title":"Vascular adhesion molecules in oral lichen planus","volume":"81","author":"Regezi","year":"1996","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","article-title":"Current controversies in oral lichen planus: Report on an international consensus meeting. 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