{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:33:45Z","timestamp":1786649625188,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Recent attention has been directed toward the role of mast cells in the pathogenesis of oral lichen planus. Mast cells are responsible for trafficking inflammatory cells into the connective tissue that in turn helps in progression and maintenance of chronicity of oral lichen planus (OLP). OLP is a T-cell-mediated chronic inflammatory oral mucosal disease of unknown etiology, and lesions contain few B-cells or plasma cells and minimal deposits of immunoglobulin or complement. Hence, OLP is ideally positioned for the study of human T-cell-mediated inflammation and autoimmunity. This study was done to evaluate the mast cell count using toluidine blue stain in OLP and compares it with oral lichenoid reaction (OLR), and to propose the possible role of mast cells in the pathogenesis of OLP and OLR. Ten cases each of OLP and OLR and five cases of normal buccal mucosa were taken from the archives of Department of Oral Pathology. The samples were stained with toluidine blue using standard toluidine blue method by Wolman 1971. An increase in mast cell count was observed in OLP and OLR in comparison to normal oral mucosa. However, no significant differences in mast cell count were noted between OLP and OLR.<\/jats:p>","DOI":"10.4103\/0973-029x.86674","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T04:46:57Z","timestamp":1319518017000},"page":"267-271","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Role of mast cells in pathogenesis of oral lichen planus"],"prefix":"10.4103","volume":"15","author":[{"given":"Rachna","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, D J College of Dental Sciences and Research, Modinagar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keya","family":"Sircar","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, D J College of Dental Sciences and Research, Modinagar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, D J College of Dental Sciences and Research, Modinagar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, D J College of Dental Sciences and Research, Modinagar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R4-20251006","first-page":"433","article-title":"Role of laminin in localization of human dermal mast cells","volume":"65","author":"Walsh","year":"1991","journal-title":"Labs Invest"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1600-0714.1995.tb01180.x","article-title":"Relationship between mast cell degranulation and inflammation in the oral cavity","volume":"24","author":"Walsh","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-0714.1990.tb00866.x","article-title":"Immuno pathogenesis of oral lichen planus","volume":"19","author":"Walsh","year":"1990","journal-title":"J Oral Pathol Med"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1034\/j.1600-0714.2002.310401.x","article-title":"Mast cell\/T cell interactions in oral lichen planus","volume":"31","author":"Zhao","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.tripleo.2009.02.020","article-title":"Correlation between clinical and histopathologic diagnosis of oral lichen planus based on modified WHO diagnostic criteria","volume":"107","author":"Rad","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R10-20251006","first-page":"175","article-title":"Evaluation of mast cells in oral lichen planus and oral Lichenoid reaction","volume":"12","author":"Jose","year":"2001","journal-title":"Indian J Dent Res"},{"key":"R11-20251006","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0714.1986.tb00622.x","article-title":"Mast cells in oral lichen planus","volume":"15","author":"Jontell","year":"1986","journal-title":"J Oral Pathol"},{"key":"R12-20251006","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2334\/josnusd.49.89","article-title":"Oral lichen planus and lichenoid reactions: Etiopathogenesis, diagnosis, management and malignant transformation","volume":"49","author":"Ismail","year":"2007","journal-title":"J Oral Sci"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01233803-201115030-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:12Z","timestamp":1786647372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01233803-201115030-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-029x.86674","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}