{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:33:49Z","timestamp":1786649629376,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The frequency of SCE in lymphocytes of ten pan chewing patients, oral submucous fibrosis (OSF) patients and age matched healthy controls were investigated. The frequency of mean SCE\/cell was found to be 10.428 \u00b1 0.755 in OSF patients, 8.752 \u00b1 0.383 in case of pan chewers as compared to 5.912 \u00b1 0.310 in controls. These values show a significant increase in frequency of SCE\/cell in OSF patients and pan chewers when compared with that of healthy controls. There is a positive correlation co-efficient of SCE\/cell with frequency, quantity, duration, intensity and period of exposure of pan-parag to oral mucosa in pan chewers and OSF patients indicating genotoxic effect of pan. Thus SCE could be used as a biomarker in chewers also to assess the level of genomic damage and to advocate efficient control measures.<\/jats:p>","DOI":"10.4103\/0973-029x.86680","type":"journal-article","created":{"date-parts":[[2011,10,25]],"date-time":"2011-10-25T04:46:57Z","timestamp":1319518017000},"page":"278-282","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients"],"prefix":"10.4103","volume":"15","author":[{"given":"D","family":"Jeyapradha","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TR","family":"Saraswathi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Vishnu Dental College, Bhimavaram, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Ragas Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Ragas Dental College and Hospital, Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251006","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0027-5107(97)00218-2","article-title":"High frequency of SCE in lymhocytes of patients with Behcet's disease","volume":"397","author":"S\u00f6nmez","year":"1998","journal-title":"Mutat Res"},{"key":"R2-20251006","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0027-5107(97)00056-0","article-title":"Dichotomous relationship between DNA reactivity and their induction of SCE in vivo and in vitro","volume":"377","author":"Labbauf","year":"1997","journal-title":"Mutat Res"},{"key":"R3-20251006","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/bjc.1986.20","article-title":"SCE frequencies in lymphocytes of tobacco\/betel nut chewers and patients with OSF","volume":"53","author":"Adhvaryu","year":"1986","journal-title":"Br J Cancer"},{"key":"R4-20251006","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1368-8375(01)00003-3","article-title":"Role of Areca nut in betel quid associated chemical carcinogenesis. Current awareness and future prospectives","volume":"37","author":"Jeng","year":"2001","journal-title":"Oral Oncol"},{"key":"R5-20251006","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0165-7992(84)90107-6","article-title":"SCE in betel and tobacco chewers","volume":"139","author":"Ghosh","year":"1984","journal-title":"Mutat Res"},{"key":"R6-20251006","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00290991","article-title":"Differential Giemsa staining of sister chromatids and the study of SCEs without autoradiography","volume":"48","author":"Wolff","year":"1974","journal-title":"Chromosoma"},{"key":"R7-20251006","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0165-4608(90)90047-E","article-title":"SCE in patients with OSF","volume":"44","author":"Ghosh","year":"1990","journal-title":"Cancer Genet Cytogenet"},{"key":"R8-20251006","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/271551a0","article-title":"SCE as an indicator of mutagenesis","volume":"271","author":"Carrano","year":"1978","journal-title":"Nature"},{"key":"R9-20251006","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/0165-4608(88)90283-X","article-title":"Effect of betal chewing on the frequency of SCE in pregnant women and women using oral contraceptives","volume":"32","author":"Ghosh","year":"1988","journal-title":"Cancer Genet Cytogenet"},{"key":"R10-20251006","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-4608(88)90142-2","article-title":"SCE in lymphocytes of patients with oral leukoplakia","volume":"36","author":"Ghosh","year":"1988","journal-title":"Cancer Genet Cytogenet"},{"key":"R11-20251006","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-1218(91)90096-5","article-title":"Cytogeneic surveillance of tobacco areca nut (mava) chewers including patients with oral cancers and premalignant conditions","volume":"261","author":"Adhvaryu","year":"1991","journal-title":"Mutat Res"}],"container-title":["Journal of Oral and Maxillofacial Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01233803-201115030-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:56:14Z","timestamp":1786647374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01233803-201115030-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-029x.86680","relation":{},"ISSN":["0973-029X","1998-393X"],"issn-type":[{"value":"0973-029X","type":"print"},{"value":"1998-393X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}