{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:42:43Z","timestamp":1783939363652,"version":"3.55.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"45","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phcog Mag"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/0973-1296.176107","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T04:42:23Z","timestamp":1455511343000},"page":"86","source":"Crossref","is-referenced-by-count":3,"title":["Endoplasmic reticulum stress-induced apoptotic pathway and mitochondrial dysregulation in HeLa cells treated with dichloromethane extract of Dillenia suffruticosa"],"prefix":"10.1177","volume":"12","author":[{"given":"LatifahSaiful","family":"Yazan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WanAbd Ghani","family":"Wan Nor Hafiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YinSim","family":"Tor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JhiBiau","family":"Foo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdin","family":"Armania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HeshuSulaiman","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"key-10.4103\/0973-1296.176107-1","first-page":"1374","volume-title":"Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012","author":"Ferlay","year":"2013","journal-title":"Eur J Cancer"},{"key":"key-10.4103\/0973-1296.176107-2","first-page":"106","volume-title":"Burden of human papillomavirus-related cervical disease in the extended middle East and north Africa-a comprehensive literature review","author":"Seoud","year":"2012","journal-title":"J Low Genit Tract Dis"},{"key":"key-10.4103\/0973-1296.176107-3","first-page":"S5","volume-title":"Pathology and epidemiology of HPV infection in females","author":"Stanley","year":"2010","journal-title":"Gynecol Oncol"},{"key":"key-10.4103\/0973-1296.176107-4","first-page":"2036","volume-title":"The human papillomavirus infection in men study: Human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States","author":"Giuliano","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key-10.4103\/0973-1296.176107-5","first-page":"1645","volume-title":"A controlled trial of a human papillomavirus type 16 vaccine","author":"Koutsky","year":"2002","journal-title":"N Engl J Med"},{"key":"key-10.4103\/0973-1296.176107-6","first-page":"S3\/1","volume-title":"Chapter 1: HPV in the etiology of human cancer","author":"Mu\u00f1oz","year":"2006","journal-title":"Vaccine"},{"key":"key-10.4103\/0973-1296.176107-7","doi-asserted-by":"crossref","unstructured":"Kong TW, Chang SJ, Paek J, Yoo SC, Yoon JH, Chang KH, et al. Comparison of concurrent chemoradiation therapy with weekly cisplatin versus monthly fluorouracil plus cisplatin in FIGO stage IIB-IVA cervical cancer. J Gynecol Oncol 2012;23:235-41","DOI":"10.3802\/jgo.2012.23.4.235"},{"key":"key-10.4103\/0973-1296.176107-8","first-page":"474","volume-title":"Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy","author":"Oike","year":"2013","journal-title":"J Radiat Res"},{"key":"key-10.4103\/0973-1296.176107-9","first-page":"158","volume-title":"A phase I study of concurrent weekly topotecan and cisplatin chemotherapy with whole pelvic radiation therapy in locally advanced cervical cancer: A Gynecologic Oncology Group study","author":"Rose","year":"2012","journal-title":"Gynecol Oncol"},{"key":"key-10.4103\/0973-1296.176107-10","first-page":"4626","volume-title":"Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: A Gynecologic Oncology Group Study","author":"Long","year":"2005","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/0973-1296.176107-11","first-page":"11","volume-title":"Cisplatin in advanced cancer of the cervix: An update","author":"Alberts","year":"1991","journal-title":"Semin Oncol"},{"key":"key-10.4103\/0973-1296.176107-12","doi-asserted-by":"crossref","unstructured":"Ahmad FB, Holdsworth DK. Traditional medicinal plants of Sabah, Malaysia. Part III. The Rungus people of Kudat. Int J Pharmacogn 1995;33:262-4.","DOI":"10.3109\/13880209509065377"},{"key":"key-10.4103\/0973-1296.176107-13","first-page":"85","volume-title":"The use of medicinal plant species by the Temuan tribe of Ayer Hitam Forest, Selangor, Peninsular Malaysia","author":"Ibrahim","year":"1999","journal-title":"Pertanika J Trop Agric Sci"},{"key":"key-10.4103\/0973-1296.176107-14","unstructured":"Mat-Salleh K, Latiff A. Medicinal Plants of Malaysia (Tumbuhan Ubatan Malaysia). Pusat Pengurusan Penyelidikan. Bangi: Universiti Kebangsaan Malaysia; 2002."},{"key":"key-10.4103\/0973-1296.176107-15","first-page":"2218","volume-title":"The effects of herbal plant extracts on the growth and sporulation of Colletotrhichum gloesporioides","author":"Johnny","year":"2010","journal-title":"J Appl Biosci"},{"key":"key-10.4103\/0973-1296.176107-16","first-page":"68","volume-title":"Antimicrobial screening of plants used for traditional medicine in the state of Perak, Peninsular Malaysia","author":"Wiart","year":"2004","journal-title":"Fitoterapia"},{"key":"key-10.4103\/0973-1296.176107-17","first-page":"1","volume-title":"Effect of Dillenia suffruticosa extract on dengue virus type 2 replication","author":"Muliawan","year":"2008","journal-title":"Univ Med"},{"key":"key-10.4103\/0973-1296.176107-18","first-page":"197","volume-title":"Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways","author":"Foo","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"key-10.4103\/0973-1296.176107-19","first-page":"55","volume-title":"Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa","author":"Tor","year":"2014","journal-title":"BMC Complement Altern Med"},{"key":"key-10.4103\/0973-1296.176107-20","first-page":"(13320","volume-title":"Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G (2)\/M cell cycle arrest","author":"Armania","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/0973-1296.176107-21","first-page":"525","volume-title":"Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G (2)\/M cell cycle arrest","author":"Armania","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/0973-1296.176107-22","first-page":"481","volume-title":"The apoptosis-necrosis continuum: Insights from genetically altered mice","author":"Zeiss","year":"2003","journal-title":"Vet Pathol"},{"key":"key-10.4103\/0973-1296.176107-23","first-page":"2603","volume-title":"Cellular stress response and apoptosis in cancer therapy","author":"Herr","year":"2001","journal-title":"Blood"},{"key":"key-10.4103\/0973-1296.176107-24","first-page":"813","volume-title":"Anticancer effects of phytosterols","author":"Woyengo","year":"2009","journal-title":"Eur J Clin Nutr"},{"key":"key-10.4103\/0973-1296.176107-25","first-page":"419","volume-title":"Aluminum induces tau aggregation in vitro but not in vivo","author":"Mizoroki","year":"2007","journal-title":"J Alzheimers Dis"},{"key":"key-10.4103\/0973-1296.176107-26","first-page":"129","volume-title":"A novel in vitro system, the integrated discrete multiple organ cell culture (IdMOC) system, for the evaluation of human drug toxicity: Comparative cytotoxicity of tamoxifen towards normal human cells from five major organs and MCF-7 adenocarcinoma breast cancer cells","author":"Li","year":"2004","journal-title":"Chem Biol Interact"},{"key":"key-10.4103\/0973-1296.176107-27","first-page":"217","volume-title":"Correlations between in vivo and in vitro effects of toxic compounds: Studies with hydrazine","author":"Waterfield","year":"1997","journal-title":"ToxicolIn Vitro"},{"key":"key-10.4103\/0973-1296.176107-28","doi-asserted-by":"crossref","unstructured":"Spiridon K, Maria B. Plants and Cancer. Plants that Fight Cancer. Boca Raton, Florida, USA: CRC Press; 2004. p. 15-34.","DOI":"10.1201\/9781420023718.ch2"},{"key":"key-10.4103\/0973-1296.176107-29","first-page":"1821","volume-title":"Cell cycle control and cancer","author":"Hartwell","year":"1994","journal-title":"Science"},{"key":"key-10.4103\/0973-1296.176107-30","first-page":"26159","volume-title":"Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase","author":"Bratton","year":"1997","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0973-1296.176107-31","first-page":"R655","volume-title":"Apoptosis: Giving phosphatidylserine recognition an assist \u2013 With a twist","author":"Fadok","year":"2003","journal-title":"Curr Biol"},{"key":"key-10.4103\/0973-1296.176107-32","first-page":"1","volume-title":"Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure","author":"van","year":"1998","journal-title":"Cytometry"},{"key":"key-10.4103\/0973-1296.176107-33","first-page":"225","volume-title":"Abnormalities of p53 protein expression in cutaneous disorders","author":"McNutt","year":"1994","journal-title":"Arch Dermatol"},{"key":"key-10.4103\/0973-1296.176107-34","first-page":"293","volume-title":"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene","author":"Miyashita","year":"1995","journal-title":"Cell"},{"key":"key-10.4103\/0973-1296.176107-35","first-page":"334","volume-title":"Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death","author":"Hockenbery","year":"1990","journal-title":"Nature"},{"key":"key-10.4103\/0973-1296.176107-36","first-page":"395","volume-title":"BCL-2 family: Regulators of cell death","author":"Chao","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"key-10.4103\/0973-1296.176107-37","first-page":"329","volume-title":"DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2","author":"Strasser","year":"1994","journal-title":"Cell"},{"key":"key-10.4103\/0973-1296.176107-38","first-page":"1799","volume-title":"Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo","author":"Miyashita","year":"1994","journal-title":"Oncogene"},{"key":"key-10.4103\/0973-1296.176107-39","first-page":"389","volume-title":"Studying endoplasmic reticulum function in vitro using siRNA","author":"Wilson","year":"2010","journal-title":"Methods Mol Biol"},{"key":"key-10.4103\/0973-1296.176107-40","first-page":"3641","volume-title":"ER chaperones in mammalian development and human diseases","author":"Ni","year":"2007","journal-title":"FEBS Lett"},{"key":"key-10.4103\/0973-1296.176107-41","first-page":"880","volume-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep"},{"key":"key-10.4103\/0973-1296.176107-42","first-page":"381","volume-title":"Roles of CHOP\/GADD153 in endoplasmic reticulum stress","author":"Oyadomari","year":"2004","journal-title":"Cell Death Differ"},{"key":"key-10.4103\/0973-1296.176107-43","first-page":"996","volume-title":"Cellular responses to endoplasmic reticulum stress and apoptosis","author":"Rasheva","year":"2009","journal-title":"Apoptosis"},{"key":"key-10.4103\/0973-1296.176107-44","first-page":"1013","volume-title":"Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities","author":"Kim","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"key-10.4103\/0973-1296.176107-45","first-page":"1635","volume-title":"The Fas signaling pathway: More than a paradigm","author":"Wajant","year":"2002","journal-title":"Science"},{"key":"key-10.4103\/0973-1296.176107-46","first-page":"1480","volume-title":"Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells","author":"Martinez","year":"2010","journal-title":"Apoptosis"},{"key":"key-10.4103\/0973-1296.176107-47","first-page":"16016","volume-title":"Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis","author":"Tan","year":"2006","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0973-1296.176107-48","first-page":"L44","volume-title":"Knockdown of ERp57 increases BiP\/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis","author":"Xu","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key-10.4103\/0973-1296.176107-49","first-page":"35","volume-title":"Ca2+-dependent redox modulation of SERCA 2b by ERp57","author":"Li","year":"2004","journal-title":"J Cell Biol"},{"key":"key-10.4103\/0973-1296.176107-50","first-page":"399","volume-title":"ER-60 (PDIA3) is highly expressed in a newly established serous ovarian cancer cell line, YDOV-139","author":"Chay","year":"2010","journal-title":"Int J Oncol"},{"key":"key-10.4103\/0973-1296.176107-51","first-page":"130","volume-title":"Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer","author":"Pressinotti","year":"2009","journal-title":"Mol Cancer"},{"key":"key-10.4103\/0973-1296.176107-52","first-page":"6016","volume-title":"Role of GRP58 in mitomycin C-induced DNA cross-linking","author":"Celli","year":"2003","journal-title":"Cancer Res"},{"key":"key-10.4103\/0973-1296.176107-53","first-page":"41","volume-title":"Expression and prognostic significance of prothymosin-alpha and ERp57 in human gastric cancer","author":"Leys","year":"2007","journal-title":"Surgery"},{"key":"key-10.4103\/0973-1296.176107-54","first-page":"341","volume-title":"Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer","author":"Ayshamgul","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"key-10.4103\/0973-1296.176107-55","first-page":"197","volume-title":"Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma","author":"Mehta","year":"2008","journal-title":"Cancer Immunol Immunother"},{"key":"key-10.4103\/0973-1296.176107-56","first-page":"2651","volume-title":"Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones","author":"Tanaka","year":"2008","journal-title":"Electrophoresis"},{"key":"key-10.4103\/0973-1296.176107-57","first-page":"410","volume-title":"Downregulation of ER60 protease inhibits cellular proliferation by inducing G1\/S arrest in breast cancer cells in vitro","author":"Lwin","year":"2012","journal-title":"Anat Rec (Hoboken)"},{"key":"key-10.4103\/0973-1296.176107-58","first-page":"1062","volume-title":"Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: The role of stress proteins ERdj5 and ERp57","author":"Corazzari","year":"2007","journal-title":"Br J Cancer"},{"key":"key-10.4103\/0973-1296.176107-59","first-page":"573","volume-title":"Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer","author":"Chung","year":"2013","journal-title":"Biomarkers"},{"key":"key-10.4103\/0973-1296.176107-60","first-page":"2255","volume-title":"Glucose-regulated protein 58 modulates cell invasiveness and serves as a prognostic marker for cervical cancer","author":"Liao","year":"2011","journal-title":"Cancer Sci"},{"key":"key-10.4103\/0973-1296.176107-61","first-page":"59","volume-title":"Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis","author":"Zong","year":"2003","journal-title":"J Cell Biol"},{"key":"key-10.4103\/0973-1296.176107-62","first-page":"98","volume-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"key":"key-10.4103\/0973-1296.176107-63","first-page":"3958","volume-title":"ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1","author":"Shiraishi","year":"2006","journal-title":"J Cell Sci"},{"key":"key-10.4103\/0973-1296.176107-64","first-page":"156","volume-title":"ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation","author":"Jimbo","year":"2003","journal-title":"Exp Cell Res"},{"key":"key-10.4103\/0973-1296.176107-65","first-page":"34287","volume-title":"An endoplasmic reticulum stress-specific caspase cascade in apoptosis.Cytochrome c-independent activation of caspase-9 by caspase-12","author":"Morishima","year":"2002","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0973-1296.176107-66","first-page":"91","volume-title":"Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57","author":"Bedard","year":"2005","journal-title":"Int Rev Cytol"},{"key":"key-10.4103\/0973-1296.176107-67","first-page":"55","volume-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"key-10.4103\/0973-1296.176107-68","first-page":"1375","volume-title":"Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and thymoquinone-based therapy","author":"Hafiza","year":"2014","journal-title":"Onco Targets Ther"},{"key":"key-10.4103\/0973-1296.176107-69","first-page":"G236","volume-title":"CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis","author":"Cazanave","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key-10.4103\/0973-1296.176107-70","first-page":"743","volume-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","author":"Kaser","year":"2008","journal-title":"Cell"},{"key":"key-10.4103\/0973-1296.176107-71","first-page":"5954","volume-title":"The p300\/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP","author":"Ch\u00e9rasse","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"key-10.4103\/0973-1296.176107-72","first-page":"778","volume-title":"Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons","author":"Willis","year":"2005","journal-title":"J Neurosci"},{"key":"key-10.4103\/0973-1296.176107-73","first-page":"18229","volume-title":"Nitric oxide and calcium participate in the fine regulation of mitochondrial biogenesis in follicular thyroid carcinoma cells","author":"Le","year":"2011","journal-title":"J Biol Chem"},{"key":"key-10.4103\/0973-1296.176107-74","first-page":"527","volume-title":"Zerumbone-loaded nanostructured lipid carrier induces G2\/M cell cycle arrest and apoptosis via mitochondrial pathway in a human lymphoblastic leukemia cell line","author":"Rahman","year":"2014","journal-title":"Int J Nanomedicine"}],"container-title":["Pharmacognosy Magazine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:51:52Z","timestamp":1674665512000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.phcog.com\/text.asp?2016\/12\/45\/86\/176107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":74,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2016]]}},"alternative-id":["176107"],"URL":"https:\/\/doi.org\/10.4103\/0973-1296.176107","relation":{},"ISSN":["0973-1296"],"issn-type":[{"value":"0973-1296","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}