{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:59:04Z","timestamp":1789167544019,"version":"build-2803163510"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>A 7-year-old female child was presented to the emergency room with acute abdominal pain and vaginal bleeding. Her assessment revealed a firm large lower abdominal mass with evidence of precocious puberty with bilaterally symmetrically enlarged breast (Tanner stage B4-P1-A1). Abdominal imaging showed a well-defined soft midline pelvi-abdominal single mass measuring 7.0 \u00d7 12.6 \u00d7 11.7 cms with no ascites. Serum tumour markers including lactate dehydrogenase (LDH), beta-subunit of human chorionic gonadotropin (B-hCG) and luteinizing hormone\/follicular stimulating hormone (LH\/FSH) were all normal. At operation, there was a huge abdominal tumour weighing 558 grams, localized to the right ovary sparing the left ovary, uterus, lymph nodes and other abdominal organs. Unilateral right salpingo-oophorectomy was performed. Histopathologic examination revealed ovarian dysgerminoma with intact capsule; FIGO Ia. Immunohistochemical stainings were positive for placental alkaline phosphatase (PALP), CD 117(c-kit) and calretinin focally but was negative for cancer antigen-125 (CA-125), B-hCG, S-100, carcinoembryonic antigen (CEA), and leukocyte common antigen (LCA). Being fitting in the low risk classification, the wait and see protocol was selected with strict follow-up with pediatric oncologist and pediatric surgeon. Along the duration of 2 years follow up, there was no more vaginal bleeding with dramatic reduction of the breast size and no recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.137920","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T11:54:49Z","timestamp":1444391689000},"page":"661","source":"Crossref","is-referenced-by-count":9,"title":["Ovarian dysgerminoma with normal serum tumour markers presenting in a child with precocious puberty"],"prefix":"10.4103","volume":"11","author":[{"given":"Naglaa M.","family":"Kamal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubaidullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kais","family":"Mazoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farahat M.","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd","family":"Jundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-103-20231126","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.jpedsurg.2004.05.023","article-title":"A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase","volume":"39","author":"Tatekawa","year":"2004","journal-title":"J Pediatr Surg"},{"key":"R2-103-20231126","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0344-0338(11)80603-5","article-title":"Gliomatosis peritonei combined with mature ovarian teratoma: Immunohistochemical observations","volume":"191","author":"Gocht","year":"1995","journal-title":"Pathol Res Pract"},{"key":"R3-103-20231126","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.sempedsurg.2005.01.005","article-title":"Malignant lesions of the ovary in childhood","volume":"14","author":"von Allmen","year":"2005","journal-title":"Semin Pediatr Surg"},{"key":"R4-103-20231126","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jpurol.2011.02.021","article-title":"Dysgerminoma and gonadal dysgenesis: The need for a new diagnosis tree for suspected ovarian tumours","volume":"7","author":"Capito","year":"2011","journal-title":"J Pediatr Urol"},{"key":"R5-103-20231126","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1097\/MPH.0b013e3181c5ad9b","article-title":"Clinical presentation and outcome of pediatric ovarian germ cell tumour: A study of 40 patients","volume":"32","author":"Biswajit","year":"2010","journal-title":"J Pediatr Hematol Oncol"},{"key":"R6-103-20231126","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0301-2115(95)02231-U","article-title":"Ovarian malignancies in childhood and adolescence","volume":"63","author":"Major","year":"1995","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R7-103-20231126","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpag.2010.06.005","article-title":"Ovarian tumours in children and adolescents-a clinical study of 52 patients in a university hospital","volume":"24","author":"Al Jama","year":"2011","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"R8-103-20231126","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/09513590601095111","article-title":"Dysgerminoma of the ovary with precocious puberty: A case report","volume":"23","author":"Song","year":"2007","journal-title":"Gynecol Endocrinol"},{"key":"R9-103-20231126","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.sempedsurg.2011.10.005","article-title":"Pediatric germ cell tumours","volume":"21","author":"Rescorla","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"R10-103-20231126","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0020-7292(00)90001-8","article-title":"FIGO Staging classification and clinical practice guidelines of gynecologic cancers. 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