{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:07Z","timestamp":1786653727772,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>A 65-year-old man presented with pulmonary nodules and a right humeral fracture. The 99mTc-hydroxy-methylene-diphosphonate (HMDP) bone scintigraphy showed high-intensity radioisotope (RI) uptake by a tumor of the right arm. Adenocarcinoma of the lung with an epidermal growth factor receptor (EGFR) mutation was diagnosed on pathological examination of the computed tomography (CT)-guided needle biopsy of the right humerus. Although, gefitinib therapy was initiated, the tumor progressed. The patient was then treated with second-line chemotherapy including bevacizumab. The CT scan showed a new bone metastasis in the ilium and right sacroiliac articulation. However, this new bone metastasis was not detected by HMDP-bone scintigraphy. Physicians should be wary of the interpretations of the findings of the 99mTc HMDP bone scintigraphy after the bevacizumab treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.138121","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T11:54:49Z","timestamp":1444391689000},"page":"652","source":"Crossref","is-referenced-by-count":0,"title":["The effect of bevacizumab for bone scintigraphy imaging"],"prefix":"10.4103","volume":"11","author":[{"given":"Takamitsu","family":"Asano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takakuwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Maeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Oguri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-60-20231126","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1056\/NEJMoa061884","article-title":"Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer","volume":"355","author":"Sandler","year":"2006","journal-title":"N Engl J Med"},{"key":"R2-60-20231126","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.surneu.2007.06.029","article-title":"The effect of bevacizumab (Avastin) on neuroimaging of brain metastases","volume":"70","author":"Mathews","year":"2008","journal-title":"Surg Neurol"},{"key":"R3-60-20231126","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/JTO.0b013e3181989e12","article-title":"Osteoblastic bone flare on F18-FDG PET in non-small cell lung cancer (NSCLC) patients receiving bevacizumab in addition to standard chemotherapy","volume":"4","author":"Krupitskaya","year":"2009","journal-title":"J Thorac Oncol"},{"key":"R4-60-20231126","first-page":"393","article-title":"Beyond anti-VEGF: Dual-targeting antiangiogenic and antiproliferative therapy","volume":"5","author":"Chen","year":"2013","journal-title":"Am J Transl Res"},{"key":"R5-60-20231126","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1158\/0008-5472.CAN-04-0074","article-title":"Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors","volume":"64","author":"Tong","year":"2004","journal-title":"Cancer Res"},{"key":"R6-60-20231126","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"R7-60-20231126","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/snuc.2001.23527","article-title":"The role of nuclear medicine in monitoring treatment in skeletal malignancy","volume":"31","author":"Cook","year":"2001","journal-title":"Semin Nucl Med"},{"key":"R8-60-20231126","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2214\/ajr.169.6.9393186","article-title":"A comparison of whole-body turboSTIR MR imaging and planar 99mTc-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases","volume":"169","author":"Eustace","year":"1997","journal-title":"AJR Am J Roentgenol"},{"key":"R9-60-20231126","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/1097-0142(197601)37:1+<480::AID-CNCR2820370713>3.0.CO;2-2","article-title":"Skeletal scanning in neoplastic disease","volume":"37","author":"O\u2032Mara","year":"1976","journal-title":"Cancer"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511030-00060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:36Z","timestamp":1786650096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511030-00060"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.138121","relation":{},"ISSN":["0973-1482"],"issn-type":[{"value":"0973-1482","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}