{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:07Z","timestamp":1786653727752,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>5-Fluorouracil (5-FU) is an active chemoetheraputic agent in many malignancies, used both in the curative and metastatic setting. Therefore, the side effect profile of 5-FU is well-described and recognized. Here, we present a case of a 28-year-old male, who received 5-FU and carboplatin concurrently, with radiation, for esophageal carcinoma. On Day 3 of his 5-FU infusion, he developed simultaneous cardiac arrhythmias, renal dysfunction, and aphasia. Magnetic resonance imaging (MRI) of his brain revealed acute demyelination of the white matter corresponding to diffusion restriction, pointing toward a small vessel injury. The 5-FU infusion was promptly discontinued and stress dose steroids were administered. The patient\u2032s symptoms resolved rapidly with no residual effects. We believe this is the first case of multisystem, small-vessel, vasculopathy secondary to 5-FU. Early recognition and prompt discontinuation of the offending drug is essential for resolution of symptoms. Steroids, with their anti-inflammatory effects can aid in rapid recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.138130","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T11:54:49Z","timestamp":1444391689000},"page":"653","source":"Crossref","is-referenced-by-count":1,"title":["5-Fluorouracil-induced vasculitic injury manifesting as a multiorgan dysfunction in a patient with esophageal carcinoma"],"prefix":"10.4103","volume":"11","author":[{"given":"Mohammad Faizan","family":"Zahid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal","family":"Masood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munira","family":"Shabbir-Moosajee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-64-20231126","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/oxfordjournals.annonc.a058098","article-title":"Combined-modality therapy in the treatment of local-regional esophageal cancer","volume":"3","author":"Saltz","year":"1992","journal-title":"Ann Oncol"},{"key":"R2-64-20231126","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/179663a0","article-title":"Fluorinated pyrimidines, a new class of tumour-inhibitory compounds","volume":"179","author":"Heidelberger","year":"1957","journal-title":"Nature"},{"key":"R3-64-20231126","first-page":"939","article-title":"Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil","volume":"40","author":"vanKuilenburg","year":"2004","journal-title":"EurJCancer"},{"key":"R4-64-20231126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/187152506775268785","article-title":"Cardiotoxicity of 5-fluorouracil","volume":"4","author":"Alter","year":"2006","journal-title":"CardiovascHematol Agents Med Chem"},{"key":"R5-64-20231126","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2230.2008.02817.x","article-title":"Small vessel vasculitis following treatment with combination 5-fluorouracil\/folinic acid and oxaliplatin","volume":"34","author":"Hill","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"R6-64-20231126","first-page":"862","article-title":"Small vessel vasculitis related to 5-fluorouracil and folinic acid","volume":"20","author":"Pellegrini","year":"2010","journal-title":"Eur J Dermatol"},{"key":"R7-64-20231126","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1200\/JCO.2003.11.055","article-title":"Small-cell cancers, and an unusual reaction to chemotherapy: Case 4. Fluorouracil-related small bowel vasculitis","volume":"21","author":"Bucaloiu","year":"2003","journal-title":"J Clin Oncol"},{"key":"R8-64-20231126","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/02841860310021545","article-title":"Upper extremity deep venous thrombosis in patients with 5-fluorouracil-containing adjuvant chemotherapy: Three case reports and a review","volume":"43","author":"Tham","year":"2004","journal-title":"Acta Oncol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511030-00064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:36Z","timestamp":1786650096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511030-00064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.138130","relation":{},"ISSN":["0973-1482"],"issn-type":[{"value":"0973-1482","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}