{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:42:47Z","timestamp":1786653767965,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"abstract":"\n \n The rarity of primary squamous cell carcinoma of salivary gland coupled with degree of morphological diversity of the salivary gland carcinomas make this group of lesions, one of the most interesting and challenging diagnosis in the head and neck region. Owing to clinical and the histological diversity, the histological examination of an entire specimen is needed for diagnosis. Although tumor grading is important, it is not an independent prognostic indicator; the diagnosis and management need careful consideration of clinical and pathological features together. There are very few reports of this tumor originating in the submandibular gland. The present article reports the rare case of primary squamous cell carcinoma of submandibular gland in a 58-year-old male with brief review.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0973-1482.144358","type":"journal-article","created":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T11:54:49Z","timestamp":1444391689000},"page":"664","source":"Crossref","is-referenced-by-count":8,"title":["Primary squamous cell carcinoma of salivary gland"],"prefix":"10.4103","volume":"11","author":[{"given":"Arati S.","family":"Panchbhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-122-20231126","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1158\/1055-9965.EPI-09-0638","article-title":"Incidence of Carcinoma of the Major Salivary Glands According to the WHO Classification, 1992 to 2006: A Population-Based Study in the United States","volume":"18","author":"Boukheris","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"R4-122-20231126","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5070\/D37P46V3Q7","article-title":"Primary epidermoid carcinoma of the submandibular salivary gland","volume":"11","author":"Elloumi-Jellouli","year":"2005","journal-title":"Dermatol Online J"},{"key":"R5-122-20231126","doi-asserted-by":"crossref","first-page":"740","DOI":"10.5858\/2001-125-0740-SCIAMS","article-title":"Squamous carcinoma in a major salivary gland: A review of the diagnostic considerations","volume":"125","author":"Taxy","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"R6-122-20231126","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/hed.21039","article-title":"Rare involvement of submandibular gland by oral squamous cell carcinoma","volume":"31","author":"Chen","year":"2009","journal-title":"Head Neck"},{"key":"R7-122-20231126","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF02348034","article-title":"Ultrastructure of primary squamous cell carcinoma of the submandibular gland","volume":"26","author":"Kaname","year":"1993","journal-title":"Med Electron Microsc"},{"key":"R8-122-20231126","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/01.MP.0000018977.18942.FD","article-title":"Hybrid carcinomas of salivary gland: Report of Nine cases with a clinicopathological, Immunohistochemical and p53 gene alteration analysis","volume":"15","author":"Nagao","year":"2002","journal-title":"Mod Pathol"},{"key":"R9-122-20231126","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0964-1955(95)00059-3","article-title":"Hybrid tumours of salivary glands. Definition and classification of five rare cases","volume":"32","author":"Seifert","year":"1996","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"R10-122-20231126","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijom.2011.12.009","article-title":"Keratocystoma of the parotid gland: A clinicopathological study and literature review","volume":"41","author":"Huang","year":"2012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"R11-122-20231126","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/01.MP.0000026053.67284.A3","article-title":"Keratocystoma of the parotid gland: A report of two cases of an unusual pathologic entity","volume":"15","author":"Nagao","year":"2002","journal-title":"Mod Pathol"},{"key":"R12-122-20231126","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-0714.2007.00543.x","article-title":"Neck mass with marked squamous metaplasia: A diagnostic pitfall in aspiration cytology","volume":"37","author":"Su","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"R14-122-20231126","first-page":"33","article-title":"Salivary gland components involved in the formation of squamous metaplasia","volume":"119","author":"Dardick","year":"1985","journal-title":"Am J Pathol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511030-00122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:42:02Z","timestamp":1786650122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511030-00122"}},"subtitle":["Report of a rare case"],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.144358","relation":{},"ISSN":["0973-1482"],"issn-type":[{"value":"0973-1482","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}