{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:47Z","timestamp":1786650107215,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Chronic myeloid leukemia (CML) is characterized by the Philadelphia (Ph) chromosome created by the reciprocal translocation t(9;22) (q34;q11), resulting in the chimeric BCR-ABL oncogene. Variant Ph' chromosome translocations involving additional chromosomes are seen in 5\u201310% of CML cases. In the present study, a novel case of Ph' chromosome-positive CML is reported, with a three-way translocation involving chromosomal regions, 9q34, 22q11.2 and 17p11.2, with additional secondary changes. The three-way translocation has resulted in a deletion of the TP53 gene located on the chromosome 17p13.1 locus. Deletion of the TP53 gene may be a major contributing factor in the development of resistance to imatinib and blast crisis.<\/jats:p>","DOI":"10.4103\/0973-1482.144372","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T01:07:21Z","timestamp":1455844041000},"page":"1037-1037","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A complex three-way translocation with deletion of the TP53 gene in a blast crisis chronic myeloid leukemia patient"],"prefix":"10.4103","volume":"11","author":[{"given":"Prajakta","family":"Kokate","sequence":"first","affiliation":[{"name":"Department of Cytogenetics, SRL Diagnostics, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Dalvi","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics, SRL Diagnostics, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarna","family":"Mandava","sequence":"additional","affiliation":[{"name":"Department of Cytogenetics, SRL Diagnostics, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3892\/ol.2012.623","article-title":"A chronic myeloid leukemia case with a unique variant Philadelphia translocation: T (9;22;21)(q34;q11;p12)","volume":"3","author":"Al-Achkar","year":"2012","journal-title":"Oncol Lett"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/0973-1482.34695","article-title":"Conventional and fluorescence in situ hybridization analysis of three-way complex BCR-ABL rearrangement in a chronic myeloid leukemia patient","volume":"3","author":"Ganguly","year":"2007","journal-title":"J Cancer Res Ther"},{"key":"R3-20260109","first-page":"29","article-title":"Two step mechanism for formation of complex 9;22 chromosome translocation in chronic myelocytic leukemia detected by fluorescence in situ hybridization","volume":"23","author":"Tanaka","year":"2001","journal-title":"Exp Oncol"},{"key":"R4-20260109","first-page":"622","article-title":"p53 loss of function enhances genomic instability and accelerates clonal evolution of murine myeloid progenitors expressing the P (210) BCR-ABL tyrosine kinase","volume":"88","author":"Brusa","year":"2003","journal-title":"Haematologica"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1038\/sj.onc.1209387","article-title":"Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: A basis for p53 haplo-insufficiency","volume":"25","author":"Lynch","year":"2006","journal-title":"Oncogene"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1073\/pnas.0602402103","article-title":"Loss of p53 impedes the antileukemic response to BCR-ABL inhibition","volume":"103","author":"Wendel","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R7-20260109","first-page":"653","article-title":"Clinical value of quantitative long-term assessment of BCR-ABL chimeric transcript in chronic myelogenous leukemia patients after allogeneic bone marrow transplantation","volume":"85","author":"Martinelli","year":"2000","journal-title":"Haematologica"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/hmg\/7.5.767","article-title":"The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia","volume":"7","author":"Jeffs","year":"1998","journal-title":"Hum Mol Genet"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-004-1204-9","article-title":"Non-recurrent 17p11.2 deletions are generated by homologous and non-homologous mechanisms","volume":"116","author":"Shaw","year":"2005","journal-title":"Hum Genet"},{"key":"R10-20260109","first-page":"5333","article-title":"Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement","volume":"58","author":"Slebos","year":"1998","journal-title":"Cancer Res"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:02:38Z","timestamp":1786647758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.144372","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}