{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:46Z","timestamp":1786650106341,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Atypical fibroxanthoma (AFX) is an uncommon spindle cell tumor with intermediate or borderline malignant potential. Clinically, it may be misdiagnosed as a squamous cell carcinoma (SCC) or malignant melanoma. Solar irradiation has been implicated in its pathogenesis. The diagnosis of AFX rests on a combination of histopathological features and a negative immunohistochemical profile. AFX is a rare tumor usually found in sun exposed skin of head and neck region in elderly Caucasian men. Rarely, it has a second peak in young adults, where it is found in trunk and extremities. The present case is reported as AFX is quite unusual in a young female with a nodule in the leg which was clinically diagnosed as a malignant melanoma. Only a few cases of AFX have been reported in young women. This case highlights the fact that accurate diagnosis of atypical fibroxanthoma is very crucial so as to avoid overenthusiastic and overzealous treatment as required for a malignant tumor.<\/jats:p>","DOI":"10.4103\/0973-1482.150353","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T01:07:21Z","timestamp":1455844041000},"page":"1027-1027","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Atypical fibroxanthoma in a young female misdiagnosed clinically as a malignant melanoma- An unusual presentation"],"prefix":"10.4103","volume":"11","author":[{"given":"Mukta","family":"Pujani","sequence":"first","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Jaseem","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Jetley","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"R1-20260109","first-page":"167","article-title":"Sixteen photogenic wonders from down under: A case series of atypical fibroxanthoma from Australia","volume":"19","author":"Avolio","year":"2011","journal-title":"Hong Kong J Dermatol Venereol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1600-0560.2009.01425.x","article-title":"Morphological and immunohistochemical characteristics of atypical fibroxanthoma with a special emphasis on potential diagnostic pitfalls: A review","volume":"37","author":"Luzar","year":"2010","journal-title":"J Cutan Pathol"},{"key":"R3-20260109","first-page":"664","article-title":"Atypical fibroxanthoma: Proceedings of 18th annual tumor seminar of San Antonio Society of Pathologists, 1961","volume":"59","author":"Helwig","year":"1963","journal-title":"Tex State J Med"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/1097-0142(19860115)57:2<368::AID-CNCR2820570230>3.0.CO;2-N","article-title":"Atypical fibroxanthoma of the skin with metastasis","volume":"57","author":"Helwig","year":"1986","journal-title":"Cancer"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/229255030701500302","article-title":"Atypical fibroxanthoma in a young woman: An unusual case presentation","volume":"15","author":"Melendez","year":"2007","journal-title":"Can J Plast Surg"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/1097-0142(197502)35:2<457::AID-CNCR2820350224>3.0.CO;2-3","article-title":"Metastatic atypical fibroxanthoma of skin","volume":"35","author":"Jacobs","year":"1975","journal-title":"Cancer"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/cup.12274","article-title":"Atypical fibroxanthoma arising in a young patient with Li-Fraumeni syndrome","volume":"41","author":"Lee","year":"2014","journal-title":"J Cutan Pathol"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.joms.2012.01.019","article-title":"Atypical Fibroxanthoma--A retrospective immunohistochemical study of 42 cases","volume":"70","author":"Singh","year":"2012","journal-title":"J Oral Maxillofac Surg"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/2278-9588.105704","article-title":"Atypical fibroxanthoma in a woman and literature review","volume":"1","author":"Erdem","year":"2012","journal-title":"J Cranio Max Dis"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:02:31Z","timestamp":1786647751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.150353","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}