{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:36Z","timestamp":1786650096586,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Extramedullary hematopoiesis (EMH) occurs in various bone marrow disorders and is most commonly seen in thalassemia and myelofibrosis. Here, we report a patient with beta-thalassemia and nasopharyngeal carcinoma having intrathoracic EMH. Our patient is a 42-year-old man who complained of chest discomfort for a month. He was confirmed nasopharyngeal carcinoma (T3N2M0) by histopathology and received chemoradiotherapy 4 months ago. The patient had a long history of beta-thalassemia and a splenectomy due to splenomegaly at 12 years of age. Computed tomography (CT) scan of the chest showed multiple soft tissue masses in bilateral thoracic cavities. 18F-FDG-PET showed no obvious increase of fluorodeoxyglucose (18F-FDG) uptake by the lesions, with an SUVmax value of approximately 2.19. These lesions were considered EMH. The patient had been followed up for more than 1 year, and there were no changes of the lesions in the thoracic cavities.<\/jats:p>","DOI":"10.4103\/0973-1482.150359","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T01:07:21Z","timestamp":1455844041000},"page":"1034-1034","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Extramedullary hematopoiesis on 18F-FDG PET\/CT in a patient with thalassemia and nasopharyngeal carcinoma: A case report and literature review"],"prefix":"10.4103","volume":"11","author":[{"given":"Dasheng","family":"Qiu","sequence":"first","affiliation":[{"name":"Positron Emission Tomography\/Computed Tomography Center, Hubei Province Cancer Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography\/Computed Tomography Center, Hubei Province Cancer Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Guo","sequence":"additional","affiliation":[{"name":"Positron Emission Tomography\/Computed Tomography Center, Hubei Province Cancer Hospital, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00062752-200003000-00006","article-title":"Clinical and hematologic aspects of hemoglobin E beta-thalassemia","volume":"7","author":"Fucharoen","year":"2000","journal-title":"Curr Opin Hematol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"E245","DOI":"10.1097\/01.BRS.0000067282.47308.4D","article-title":"Hypertransfusion: A successful method of treatment in thalassemia intermedia patients with spinal cord compression secondary to extramedullary hematopoiesis","volume":"28","author":"Chehal","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5812\/iranjradiol.8064","article-title":"Effect of hypertransfusion on extramedullary hematopoietic compression mass in thalassemia major: A case report","volume":"9","author":"Emamhadi","year":"2012","journal-title":"Iran J Radiol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/197140091302600119","article-title":"Progressive spinal cord compression due to epidural extramedullary hematopoiesis in thalassaemia intermedia. 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