{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:30Z","timestamp":1786649850999,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Klinefelter syndrome (KS) is a well-documented abnormality of the sex chromosome, with an incidence of 1 in 600 newborn males. It is characterized by a 47, XXY or a mosaic karyotype, hypergonadotrophic hypogonadism, infertility, reduced body hair, gynecomastia, and tall stature. Different neoplasms such as breast, testicular, and lymphoreticular malignancies may occur in 1% to2% of the cases with KS. Herein we describe a case of mediastinal mixed germ cell tumor (GCT) in a 40-year-old male with KS. Interestingly, this case also had mitral valve prolapse, and an incidental papillary microcarcinoma of the thyroid gland. In view of the presence of pulmonary nodules, antemortem differential diagnoses considered were mycobacterial infection, lymphoma, thymic carcinoma, and a primary\/metastatic neoplasm of the lung. As GCT was not considered, the serum markers of a GCT were not performed. The diagnosis of this rare mediastinal mixed GCT with KS was made at autopsy.<\/jats:p>","DOI":"10.4103\/0973-1482.150697","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T01:07:21Z","timestamp":1455844041000},"page":"1034-1034","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Mediastinal mixed germ cell tumor in an infertile male with Klinefelter syndrome: A case report and literature review"],"prefix":"10.4103","volume":"11","author":[{"given":"Dinesh","family":"Pradhan","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Pushpanjali Crosslay Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lileswar","family":"Kaman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasreman","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Moffitt Cancer Center, Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit K.","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Pushpanjali Crosslay Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/ajmg.a.31103","article-title":"Klinefelter syndrome and mediastinal germ cell tumors","volume":"140","author":"Volkl","year":"2006","journal-title":"Am J Med Genet A"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.humpath.2006.01.029","article-title":"Extragonadal germ cell tumors are often associated with Klinefelter syndrome","volume":"37","author":"Aguirre","year":"2006","journal-title":"Hum Pathol"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/bjc.1995.85","article-title":"Cancer incidence in men with Klinefelter syndrome","volume":"71","author":"Hasle","year":"1995","journal-title":"Br J Cancer"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF01959079","article-title":"Mediastinal germ cell tumor associated with Klinefelter syndrome. 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An echocardiographic study in twenty-two patients","volume":"38","author":"Fricke","year":"1984","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:09Z","timestamp":1786647549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.150697","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}