{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:28Z","timestamp":1786649848749,"version":"build-2736575974"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>A 22-year-old female with epistaxis and nose block had a pink, smooth, mucosa covered lesion occupying the nasopharynx. The histopathology and immunohistochemistry of the lesion confirmed the diagnosis of clear cell carcinoma (CCC). Detailed evaluation ruled out a primary tumor elsewhere in the body. After complete excision of the tumor patient received radiotherapy (60 Gray in 30 fractions over 6 weeks). Patient is recurrence free on her 3-year follow-up. Primary CCC of the head and neck is rare. In the past 30 years, less than 100 cases have been reported in English literature. Out of these, only nine cases had nasopharyngeal origin. The literature review of those cases along with our case report suggest that complete excision of nasopharyngeal CCC along with radiotherapy leads to prolonged recurrence free interval. However, extensive tumors of nasopharynx exhibit poor prognosis with repeated local recurrences.<\/jats:p>","DOI":"10.4103\/0973-1482.157319","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:48:49Z","timestamp":1455842929000},"page":"928-930","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Primary clear cell carcinoma of the nasopharynx"],"prefix":"10.4103","volume":"11","author":[{"given":"Deviprasad","family":"Dosemane","sequence":"first","affiliation":[{"name":"Departments of Otorhinolaryngology and Otolaryngology, Kasturba Medical College, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora D.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kasturba Medical College, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suja S.","family":"Sreedharan","sequence":"additional","affiliation":[{"name":"Departments of Otorhinolaryngology and Otolaryngology, Kasturba Medical College, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00000478-199502000-00018","article-title":"Hyalinizing clear cell carcinoma of salivary gland: Report of a case with multiple recurrences over 12 years","volume":"19","author":"Tang","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.otohns.2008.06.015","article-title":"Primary clear cell carcinoma of the nasopharynx","volume":"139","author":"Cheng","year":"2008","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s10330-010-0611-8","article-title":"Primary clear cell carcinoma of the nasopharynx: A case report","volume":"9","author":"Wang","year":"2010","journal-title":"Chin Ger J Clin Oncol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1177\/1066896914526778","article-title":"Nasopharyngeal hyalinizing clear cell carcinoma: Report of the histopathologic features of a case showing EWSR1 rearrangements by FISH and literature review","volume":"22","author":"Ceballos S\u00e1enz","year":"2014","journal-title":"Int J Surg Pathol"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0964-1955(93)90019-B","article-title":"On the differential diagnosis of clear cell tumours of the head and neck","volume":"29B","author":"Eversole","year":"1993","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1177\/014556131109000512","article-title":"Clear cell adenocarcinoma of the base of the tongue: A case report and review of the literature","volume":"90","author":"Casani","year":"2011","journal-title":"Ear Nose Throat J"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:08Z","timestamp":1786647548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.157319","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}