{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:37Z","timestamp":1786649857585,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Myeloid neoplasms associated with platelet-derived growth factor b (PDGFRB) rearrangement usually keep only one morphologic type unless blast crisis. We describe a unique case of hematological features transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia, and imatinib showed no clinical therapeutic effects. The phenomenon indicates that different types of myeloid neoplasms associated with PDGFRB rearrangement can transform into one another with the progression of the disease, and to some extent, this transformation suggests the aggravation of disease.<\/jats:p>","DOI":"10.4103\/0973-1482.160922","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:48:49Z","timestamp":1455842929000},"page":"914-916","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia as progression of myeloid neoplasm with platelet-derived growth factor \u00df rearrangement"],"prefix":"10.4103","volume":"11","author":[{"given":"Xue","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1746-1596-7-19","article-title":"Concurrent acute myeloid leukemia and T lymphoblastic lymphoma in a patient with rearranged PDGFRB genes","volume":"7","author":"Chang","year":"2012","journal-title":"Diagn Pathol"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaci.2012.02.019","article-title":"Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes","volume":"130","author":"Valent","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1756-8722-7-26","article-title":"Discovery of imatinib-responsive FIP1L1-PDGFRA mutation during refractory acute myeloid leukemia transformation of chronic myelomonocytic leukemia","volume":"7","author":"Shah","year":"2014","journal-title":"J Hematol Oncol"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1080\/10428190802123499","article-title":"Chronic myelomonocytic leukemia with antecedent refractory anemia with excess blasts: Further evidence for the arbitrary nature of current classification systems","volume":"49","author":"Breccia","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1309\/FU04P779U310R3EE","article-title":"Chronic myelomonocytic leukemia evolving from preexisting myelodysplasia shares many features with de novo disease","volume":"126","author":"Wang","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clml.2011.03.019","article-title":"Cytopenia, dysplasia, and monocytosis: A precursor to chronic myelomonocytic leukemia or a distinct subgroup? Case reports and review of literature","volume":"11","author":"Singh","year":"2011","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1158\/0008-5472.CAN-04-4263","article-title":"The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2","volume":"65","author":"Reiter","year":"2005","journal-title":"Cancer Res"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1182\/blood.V99.3.840","article-title":"Prognostic factors and scoring systems in chronic myelomonocytic leukemia: A retrospective analysis of 213 patients","volume":"99","author":"Onida","year":"2002","journal-title":"Blood"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2011-01-331678","article-title":"Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression","volume":"118","author":"Klampfl","year":"2011","journal-title":"Blood"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:14Z","timestamp":1786647554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201511040-00042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.160922","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}