{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:51Z","timestamp":1786649751969,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To analyze the clinicopathological features of invasive lobular carcinoma (ILC) and compare them with invasive ductal carcinoma (IDC), hoping to find the fact of ILC in China and assist the decision makers with proper individualized treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A nationwide multicenter retrospective study was performed. A total of 4211 primary breast cancer cases were randomly selected from 1999 to 2008 in seven regions of China. ILC cases were compared with IDC by clinicopathological features and molecular subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 135 (3.2%) ILC and 3471 (82.4%) IDC cases were included for analysis. The age, tumor size, menopausal state, family history, nodal status, and stage of ILC were similar to that of IDC. ILC was more likely to be positive for estrogen receptor (65.5% vs. 57.7%) and progesterone receptor (64.7% vs. 58.5%), and less likely to overexpress human epidermal growth factor receptor-2 (17.3% vs. 23.6%). Even though, these differences are not significant, the proportion of luminal A type of ILC is significantly larger than that of IDC (54.8% vs. 42.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ILC has a larger proportion of luminal A type compared with IDC. Larger sample size study for better known of molecular subtypes of ILC is needed in future to individualize the treatment decision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.163851","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T23:57:49Z","timestamp":1441065469000},"page":"S89-S94","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathological features of invasive lobular carcinoma of the breast: A nationwide multicenter study in China"],"prefix":"10.4103","volume":"11","author":[{"given":"M. Z.","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Zhejiang Cancer Hospital, Banshanqiao, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. F.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Zhejiang Cancer Hospital, Banshanqiao, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. M.","family":"He","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Zhejiang Cancer Hospital, Banshanqiao, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. L.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Zhejiang Cancer Hospital, Banshanqiao, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, Center of Breast Disease, Beijing, China"},{"name":"Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, Center of Breast Disease, Beijing, China"},{"name":"Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Xu","sequence":"additional","affiliation":[{"name":"Depatment of Breast-Thyroid Surgery, Xiangya Second Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. H.","family":"Tang","sequence":"additional","affiliation":[{"name":"Depatment of Breast-Thyroid Surgery, Xiangya Second Hospital, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. N.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, Center of Breast Disease, Beijing, China"},{"name":"Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. L.","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, Center of Breast Disease, Beijing, China"},{"name":"Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology, Center of Breast Disease, Beijing, China"},{"name":"Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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