{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:50:07Z","timestamp":1789019407261,"version":"build-2803163510"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Context\/Background:<\/jats:title>\n                    <jats:p>Tooth agenesis (excluding third molars) is a common congenital disorder that affects 2.2\u201310% of the general population. A number of different genes have been shown to be associated with cases of tooth agenesis including AXIN2, IRF6, FGFR1, MSX1, PAX9, and TGFA. Wingless\/integration signaling gene, AXIN2, is linked to tooth agenesis and also to colorectal cancer (CRC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To analyze the correlation between tooth agenesis and CRC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study included 50 individuals, who were divided into two groups. Group A: 25 individuals diagnosed with CRC and Group B: 25 individuals as a control group. The clinical details were recorded using preformed questionnaire, approved by ethical committee. Orthopantomogram was obtained for all the cases and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We observed that 16% of cases and 8% of controls reported having tooth agenesis and there was no statistical significance of difference between them (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.384). Among the study group, 4% reported oligodontia and 12% cases reported hypodontia. In the control group 8% reported hypodontia, there was no incidence of oligodontia. Additional finding in the study group was that 24% cases had fissured tongue which was not seen in the control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Individuals with tooth agenesis might have an increased risk for CRC. A larger epidemiological study along with genetic mapping and gene sequencing is necessary to rule out the risk and relationship between tooth agenesis and CRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.168997","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T08:26:37Z","timestamp":1528791997000},"page":"527-531","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Tooth agenesis: A susceptible indicator for colorectal cancer?"],"prefix":"10.4103","volume":"14","author":[{"given":"M. V.","family":"Paranjyothi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Farooqia Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Kumaraswamy","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Farooqia Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna Firdose","family":"Begum","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Farooqia Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Manjunath","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Farooqia Dental College and Hospital, Mysore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Litha","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Farooqia Dental College and Hospital, Mysore, Karnataka, 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