{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:13Z","timestamp":1786650013449,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Both induction chemotherapy (ICT) followed by irradiation and concurrent chemotherapy and radiotherapy have been reported as valuable alternatives to total laryngectomy in patients with advanced larynx\/hypopharynx cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Of the 60 enrolled patients, randomly assigned into two groups (30 in each group) previously untreated patients with stages III to IV larynx\/hypopharynx squamous cell carcinoma were assigned to received two cycles of ICT with interval of 3 weeks (a) Group A paclitaxel 175 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      on day 1 and carboplatin 450 mg on day 2 (PC), (b) Group B docetaxel and cisplatin 75 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      each on day 1 and ifosfamide 2 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      on day 1\u20133 along with mesna (docetaxel-ifosfamide-cisplatin). Both groups were followed by conventional radiotherapy (60\u201370 Gy\/5#\/week). Primary end point was a response after ICT. Secondary endpoints included acute toxicities and overall response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Baseline patient and tumor characteristics were well balanced between both groups, the response after ICT seen was 80% in Group A complete response (CR) 36.6% and partial response (PR) 43.3% and in Group B 79% response, CR 33% and PR 46%; whereas toxicities in Group B grade 3\/4 neutropenia and grade 2\/3 vomiting more severe than Group A. Radiation therapy was well tolerable to both groups with mild side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Definite role of neoadjuvant chemotherapy in locally advanced larynx\/laryngopharyngeal cancer as organ preservation therapy. The efficacy found was quite similar and improved response in both groups except toxicity profile of Group B more severe, requiring the use of colony stimulating factors and supportive care along with.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.172122","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:33:49Z","timestamp":1469511229000},"page":"920-925","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of outcome and toxicity of two different regimes of neoadjuvant chemotherapy followed by external beam radiotherapy in stages III and IV larynx and laryngopharyngeal malignancies in years 2013\u20132014"],"prefix":"10.4103","volume":"12","author":[{"given":"Sonu","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Radiotherapy and ENT, Government of Cancer Hospital, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapesh","family":"Pounikar","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and ENT, Government of Cancer Hospital, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preety","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and ENT, Government of Cancer Hospital, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and ENT, Government of Cancer Hospital, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagram","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and ENT, Government of Cancer Hospital, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Fakhruddin","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and ENT, Government of Cancer Hospital, MGM Medical College, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5005\/jp-journals-10001-1132","article-title":"Head and neck cancer burden in India","volume":"4","author":"Kulkarni","year":"2013","journal-title":"Int J Head Neck Surg"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0002-9610(74)90262-1","article-title":"Epidermoid carcinoma of the supraglottic larynx. 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