{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:22Z","timestamp":1786649782280,"version":"build-2736575974"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to determine whether the addition of bumetanide (BU), a glycolytic metabolism pathway inhibitor, to arterial embolization improves tumor necrosis of N1-S1 hepatocellular carcinoma in a rat model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      N1-S1 tumors were surgically implanted in the liver of 14 Sprague-Dawley rats. The rats were divided into three groups: In control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5), 1 ml of normal saline was injected intra-arterially. The tumor in the transarterial embolization group (TAE,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4) was embolized using 10 mg of 50\u2013150 \u03bc polyvinyl alcohol (PVA) particles and embolization plus BU group (TAE + BU,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 5) were embolized with 10 mg of PVA plus 0.04 mg\/kg of BU. Tumor volume was measured using two-dimensional ultrasound before intervention and twice a week afterward. Relative tumor volume after the intervention was calculated as the percentage of preinterventional tumor volume. After 4 weeks of observation, the rats were sacrificed for histopathological evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      No statistically significant difference was detected in the preintervention tumor sizes between the three groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05). In the control group, the relative tumor volume increased to 142.5% larger than baseline measurements. In the TAE group, the tumor volume decreased by 18.2 \u00b1 12.2%. The tumor volume in the TAE + BU group decrease by 90.4 \u00b1 10.2%, which was 72.2% more than in TAE only group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001). Histopathological evaluation demonstrated no residual tumor in the TAE + BU group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Tumor necrosis significantly increased in N1-S1 tumor that received BU at the time of TAE when compared to TAE alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.172127","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T13:00:53Z","timestamp":1767790853000},"page":"533-537","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Efficiency of combined blocking of aerobic and glycolytic metabolism pathways in treatment of N1-S1 hepatocellular carcinoma in a rat model"],"prefix":"10.4103","volume":"13","author":[{"given":"Hooman","family":"Yarmohammadi","sequence":"first","affiliation":[{"name":"Department of Radiology, Division of Interventional Radiology and Image Guided Therapy, Memorial Sloan Kettering Cancer Center, New York 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke R.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Virginia, Charlottesville, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Erinjeri","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Interventional Radiology and Image Guided Therapy, Memorial Sloan Kettering Cancer Center, New York 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106-5056, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata A.","family":"Exner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Case Western Reserve University, Case Center for Imaging Research, Cleveland, Ohio 44106-5056, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Case Western Reserve University, Case Center for Imaging Research, Cleveland, Ohio 44106-5056, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena N.","family":"Petre","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Interventional Radiology and Image Guided Therapy, Memorial Sloan Kettering Cancer Center, New York 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Boas","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Interventional Radiology and Image Guided Therapy, Memorial Sloan Kettering Cancer Center, New York 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etay","family":"Ziv","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Interventional Radiology and Image Guided Therapy, Memorial Sloan Kettering Cancer Center, New York 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Haaga","sequence":"additional","affiliation":[{"name":"Department of Radiology, Case Western Reserve University, Cleveland, Ohio 44106-5056, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260109","first-page":"74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/lt.23846","article-title":"Bland embolization versus chemoembolization of hepatocellular carcinoma before transplantation","volume":"20","author":"Kluger","year":"2014","journal-title":"Liver Transpl"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-3-642-16037-0_13","article-title":"Transarterial therapies for hepatocellular carcinoma","volume":"190","author":"Tsochatzis","year":"2013","journal-title":"Recent Results Cancer Res"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","article-title":"Prognosis of hepatocellular carcinoma: The BCLC staging classification","volume":"19","author":"Llovet","year":"1999","journal-title":"Semin Liver Dis"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00270-006-0062-3","article-title":"Transarterial therapy for hepatocellular carcinoma: Which technique is more effective? 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