{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:42Z","timestamp":1786649802761,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To investigate whether the presence of serous tubal intraepithelial carcinoma (STIC) is associated with clinical outcomes in a nonselected (unknown BRCA status) cohort of patients with a high-grade serous carcinoma (HGSC) of the ovary, fallopian tube, and peritoneum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>A prospective case-series with planned data collection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>The study was conducted in a total of 131 patients, who underwent primary cytoreductive surgery between 2007 and 2012. Histological examination of the fallopian tubes included the \u201csectioning and extensively examining the fimbriated end\u201d protocol. The diagnosis of STIC was based on the combination of morphology and immunohistochemistry. The patients were divided into two groups according to the absence or presence of STIC and compared clinicopathologically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>Analyses were performed using PASW 18 (SPSS\/IBM, Chicago, IL, USA) software. The primary outcome was progression-free survival (PFS), and the secondary outcome was overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      STIC was identified in 20.6% of patients. Median follow-up time was 49.5 months for the STIC-positive group and 38.0 months for the STIC-negative group. Study groups were comparable in terms of clinicopathological characteristics with the exception that patients with STIC had less lymph node involvement (55.0% vs. 65.4%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and more diagnosis of primary tubal carcinoma (29.6% vs. 3.8%, P = 0.001) compared to those without STIC. No statistically significant differences in terms of PFS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.462) and OS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.501) were observed between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The absolute identification of the origin of tumor cell does not seem to significantly affect the clinical course of the patients with HGSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.172130","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T08:26:37Z","timestamp":1528791997000},"page":"587-592","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The clinical impact of serous tubal intraepithelial carcinoma on outcomes of patients with high-grade serous carcinoma of the ovary, fallopian tube, and peritoneum"],"prefix":"10.4103","volume":"14","author":[{"given":"Tayfun","family":"Toptas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncological Surgery, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Pestereli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Gynecopathology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayup","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Gynecologic Oncological Surgery, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulgun","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Gynecopathology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyda","family":"Karaveli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Division of Gynecopathology, Akdeniz University School of Medicine, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1097\/00000478-200110000-00009","article-title":"Occult carcinoma in prophylactic oophorectomy specimens: Prevalence and association with BRCA germline mutation status","volume":"25","author":"Colgan","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/gyno.2002.6779","article-title":"Pathologic findings in prophylactic oophorectomy specimens in high-risk women","volume":"87","author":"Leeper","year":"2002","journal-title":"Gynecol Oncol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0090-8258(03)00365-2","article-title":"BRCA1\/2-related ovarian cancers are of tubal origin: A hypothesis","volume":"90","author":"Piek","year":"2003","journal-title":"Gynecol Oncol"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ygyno.2012.02.024","article-title":"Evolution of surgical treatment paradigms for advanced-stage ovarian cancer: Redefining 'optimal' residual disease","volume":"125","author":"Chang","year":"2012","journal-title":"Gynecol Oncol"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging classification for cancer of the ovary, fallopian tube, and peritoneum","volume":"124","author":"Prat","year":"2014","journal-title":"Int J Gynaecol Obstet"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/modpathol.2011.85","article-title":"Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: An immunohistochemical and nucleotide sequencing analysis","volume":"24","author":"Yemelyanova","year":"2011","journal-title":"Mod Pathol"},{"key":"R11-20260109","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"R12-20260109","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2214\/AJR.09.4110","article-title":"Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know","volume":"195","author":"Nishino","year":"2010","journal-title":"AJR Am J Roentgenol"},{"key":"R13-20260109","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/IGC.0b013e3182049273","article-title":"Outcomes after multiple lines of chemotherapy for platinum-resistant epithelial cancers of the ovary, peritoneum, and fallopian tube","volume":"21","author":"Griffiths","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"R14-20260109","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ygyno.2010.11.020","article-title":"\u201cPrimary peritoneal\u201d high-grade serous carcinoma is very likely metastatic from serous tubal intraepithelial carcinoma: Assessing the new paradigm of ovarian and pelvic serous carcinogenesis and its implications for screening for ovarian cancer","volume":"120","author":"Seidman","year":"2011","journal-title":"Gynecol Oncol"},{"key":"R15-20260109","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/PGP.0b013e318216d447","article-title":"p53 signature and serous tubal in-situ carcinoma in cases of primary tubal and peritoneal carcinomas and serous borderline tumors of the ovary","volume":"30","author":"Leonhardt","year":"2011","journal-title":"Int J Gynecol Pathol"},{"key":"R16-20260109","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ygyno.2012.12.006","article-title":"Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma","volume":"129","author":"Lengyel","year":"2013","journal-title":"Gynecol Oncol"},{"issue":"Suppl 10","key":"R17-20260109","doi-asserted-by":"crossref","first-page":"x16","DOI":"10.1093\/annonc\/mdt463","article-title":"Origin and molecular pathogenesis of ovarian high-grade serous carcinoma","volume":"24","author":"Kurman","year":"2013","journal-title":"Ann Oncol"},{"key":"R18-20260109","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/PAS.0b013e3181868904","article-title":"Serous tubal intraepithelial carcinoma and the dominant ovarian mass: Clues to serous tumor origin?","volume":"33","author":"Roh","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"R19-20260109","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/PGP.0b013e3181c713a8","article-title":"Serous tubal intraepithelial carcinoma: Diagnostic reproducibility and its implications","volume":"29","author":"Carlson","year":"2010","journal-title":"Int J Gynecol Pathol"},{"key":"R20-20260109","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ygyno.2007.09.027","article-title":"Serous fallopian tube carcinoma: A retrospective, multi-institutional case-control comparison to serous adenocarcinoma of the ovary","volume":"107","author":"Moore","year":"2007","journal-title":"Gynecol Oncol"},{"key":"R21-20260109","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1002\/cncr.23957","article-title":"Improved survival for fallopian tube cancer: A comparison of clinical characteristics and outcome for primary fallopian tube and ovarian cancer","volume":"113","author":"Wethington","year":"2008","journal-title":"Cancer"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201814030-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:35Z","timestamp":1786647515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201814030-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.172130","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}