{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:03Z","timestamp":1786650063701,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Primary mediastinal synovial sarcomas are exceedingly uncommon tumors. Herein, we present the case of primary mediastinal synovial sarcoma (monophasic spindle cell-shaped variant) fully occupying the right hemithorax in a 37-year-old woman who presented to clinic with a 2-month history of right-sided chest pain and shortness of breath. Although extremely rare, however, synovial sarcoma should be considered in the differential diagnosis of all monophasic and biphasic spindle cell neoplasms of the mediastinum. Despite molecular testing for (t[x; 18] [p11.2; q11.2]) is characteristically positive in 90% of synovial sarcoma cases, it is not routinely done. Histopathological and immunohistochemical analyses can greatly confirm the diagnosis. Optimal surgical resection is the standard of care. Adjuvant therapy (radiotherapy and\/or chemotherapy) is indicated in inoperable advanced disease or unachieved surgical tumor-free surgical margins. Prognosis is poor with a 5-year overall survival (OS) rate of 35.7%. Early diagnosis and prompt appropriate management yield better disease-free and OS rates.<\/jats:p>","DOI":"10.4103\/0973-1482.172137","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T08:26:37Z","timestamp":1528791997000},"page":"682-686","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Huge primary mediastinal synovial sarcoma fully occupying the right hemithorax"],"prefix":"10.4103","volume":"14","author":[{"given":"Ahmed","family":"Abu-Zaid","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"},{"name":"Department of Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"AlNajjar","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Alshawaf","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor","family":"Alqeshtaini","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rwan","family":"Alhaidar","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamayel","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"AlKattan","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"},{"name":"Department of Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"R1-20260109","first-page":"412527","article-title":"Primary synovial sarcomas of the mediastinum: A systematic review and pooled analysis of the published literature","volume":"2014","author":"Salah","year":"2014","journal-title":"ISRN Oncol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3892\/ol.2013.1649","article-title":"Primary giant mediastinal synovial sarcoma of the neck: A case report and review of the literature","volume":"7","author":"Zhou","year":"2014","journal-title":"Oncol Lett"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/j.athoracsur.2014.05.039","article-title":"Surgical excision for mediastinal synovial sarcoma with limited response to chemoradiotherapy","volume":"98","author":"Kara","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"R4-20260109","first-page":"651813","article-title":"Primary mediastinal synovial sarcoma presenting as superior vena cava syndrome: A rare case report and review of the literature","volume":"2015","author":"Madabhavi","year":"2015","journal-title":"Case Rep Oncol Med"},{"key":"R5-20260109","first-page":"87","article-title":"Synovial sarcoma-AV. 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