{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:25Z","timestamp":1786728625168,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>Skin metastases, as a presenting symptom of gastrointestinal malignancies, are very rare and signify aggressive disease. They usually occur after a long period of diagnosis and along with other visceral metastases. We present the case of an 18-year-old male with diffuse subcutaneous metastases as a presenting feature and as the only site of distant metastases due to rectosigmoid adenocarcinoma. They clinically mimic benign skin lesions and the patient might not present to an oncologist. The diagnosis has to be established by skin biopsy, which will show tumor cell infiltration of the epidermis, dermis, and\/or subcutaneous fat. There is no established local treatment for diffuse lesions. Systemic chemotherapy indicated for metastatic colon carcinoma was employed with not much favorable response. Irinotecan based chemotherapy also resulted in posterior reversible encephalopathy syndrome in this patient. Overall, the disease carries a poor prognosis and with no effective treatment available the survival is less than a year.<\/jats:p>","DOI":"10.4103\/0973-1482.172586","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T08:26:37Z","timestamp":1528791997000},"page":"716-718","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Multiple subcutaneous metastases as the solitary presenting site of colorectal cancer"],"prefix":"10.4103","volume":"14","author":[{"given":"Chandran","family":"Nallathambi","sequence":"first","affiliation":[{"name":"Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indibor Yengkhom","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuchamo","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Regional Institute of Medical Sciences, Imphal, Manipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/archderm.143.5.613","article-title":"Clinicopathologic correlation of cutaneous metastases: Experience from a cancer center","volume":"143","author":"Sariya","year":"2007","journal-title":"Arch Dermatol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4103\/1947-2714.118918","article-title":"The presentation, pathology, and current management strategies of cutaneous metastasis","volume":"5","author":"Wong","year":"2013","journal-title":"N Am J Med Sci"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0190-9622(90)70002-Y","article-title":"Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients","volume":"22","author":"Lookingbill","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.0303-6987.2004.00207.x","article-title":"Cutaneous metastasis: A clinical, pathological, and immunohistochemical appraisal","volume":"31","author":"Saeed","year":"2004","journal-title":"J Cutan Pathol"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00432-008-0432-0","article-title":"Cutaneous metastases of visceral tumours: A review","volume":"135","author":"Nashan","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"R6-20260109","first-page":"1310","article-title":"Survival after cutaneous metastasis: A study of 200 cases","volume":"128","author":"Schoenlaub","year":"2001","journal-title":"Ann Dermatol Venereol"},{"key":"R7-20260109","first-page":"219","volume":"19","year":"2010","journal-title":"Prescrire Int"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/1477-7819-12-264","article-title":"Fatal outcome of posterior \u201creversible\u201d encephalopathy syndrome in metastatic colorectal carcinoma after irinotecan and fluoropyrimidine chemotherapy regimen","volume":"12","author":"Dedic Plavetic","year":"2014","journal-title":"World J Surg Oncol"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1743-7563.2012.01544.x","article-title":"Posterior reversible encephalopathy syndrome following chemotherapy with oxaliplatin and a fluoropyrimidine: A case report and literature review","volume":"8","author":"Femia","year":"2012","journal-title":"Asia Pac J Clin Oncol"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1200\/JCO.2007.12.6102","article-title":"Colorectal carcinoma in childhood and adolescence: A clinicopathologic review","volume":"25","author":"Hill","year":"2007","journal-title":"J Clin Oncol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201814030-00048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:29:29Z","timestamp":1786724969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201814030-00048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.172586","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}