{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:09Z","timestamp":1786650009729,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the severity of acute toxicities of postoperative adjuvant therapy on oral squamous cell carcinoma (OSCC) patients with and without submucous fibrosis (SMF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study population comprised treatment na\u00efve OSCC patients who underwent curative intent surgical resection from June 2010 to April 2011 followed by adjuvant treatment. Patients whose treatment details including toxicity profile were available were included in the study. One-hundred nine patients met the inclusion criteria of whom 36 had associated SMF and 73 no SMF. Overall, 35 patients received chemotherapy (CT) with radiotherapy (RT) and the rest only RT. Forty-two patients had centralized and 67 lateralized lesions. All patients with centralized lesions and 3 with lateralized lesion received radiation to bilateral face and neck. All others received ipsilateral radiation. The severity of mucositis, xerostomia, and skin toxicity (as per radiation therapy oncology group scale of acute toxicity) was compared between the SMF and non-SMF groups and patients with centralized and lateralized lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      CT in addition to RT did not add significant to the assessed toxicities. Severe mucositis as well as treatment breaks were more in SMF group as compared to non-SMF group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 and &lt;0.001 respectively). Severe mucositis and xerostomia were more in centralized than in lateralized lesions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002 and 0.00 respectively). In subgroups of lateralized as well as centralized lesions, severe mucositis was more common in SMF patients than those without SMF (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and 0.02 respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>OSCC patients with SMF have worse toxicity with adjuvant therapy and require good supportive care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.174187","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:33:49Z","timestamp":1469511229000},"page":"932-937","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Acute toxicities of adjuvant treatment in patients of oral squamous cell carcinoma with and without submucous fibrosis: A retrospective audit"],"prefix":"10.4103","volume":"12","author":[{"given":"Swagnik","family":"Chakrabarti","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery, TATA Memorial Hospital, Parel, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aseem","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, TATA Memorial Hospital, Parel, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Prakash","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, TATA Memorial Hospital, Parel, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurva","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, TATA Memorial Hospital, Parel, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, TATA Memorial Hospital, Parel, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, TATA Memorial Hospital, Parel, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.oraloncology.2005.08.005","article-title":"Oral submucous fibrosis: Review on aetiology and pathogenesis","volume":"42","author":"Tilakaratne","year":"2006","journal-title":"Oral Oncol"},{"key":"R2-20260109","first-page":"985","article-title":"Oral submucous fibrosis: Etiology, pathogenesis, and future 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