{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:42:01Z","timestamp":1791906121281,"version":"4.3.4"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To assess cancer incidence and all-cause mortality trends in HIV-positive patients in Algeria before and during the highly active antiretroviral therapy (HAART) era.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings and Design:<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>We used hospital-based data of patients with HIV\/AIDS between January 1988 and December 2010.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statistical Analysis Used:<\/jats:title>\n                    <jats:p>Cancer incidence, standardized mortality ratios (SMRs), risk of death, and proportion of HIV-positive patients treated before and during the HAART era were calculated. The joinpoint model was used to assess the magnitude of changes in SMRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In 1988\u20132010, 156 patients were diagnosed as HIV-positive. During pre-HAART era, Kaposi sarcoma (KS) incidence was 5%. After the introduction of HAART, KS incidence decreased to 2%. No other AIDS-related cancer was diagnosed during the study. One-third died (52\/156), of which 83.6% died in the same year as or in the year after HIV diagnosis; median age at death (interquartile range) was 34.5 (11.8) years. Yearly risk of death declined from 100% in 1998 to 8% in 2010; percentage of patients treated with HAART increased from 13% in 1998 to &gt;80% after 2002. Overall SMR decreased from 200.2 (95% confidence interval [95% CI], 123.2\u2013325.2) before the HAART era to 91.4 (95% CI, 66.0\u2013126.6) thereafter. From 2003, yearly SMRs decreased significantly by 66.1% (P &lt; 0.05) until 2006 but not thereafter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Since 1998, the proportion of HIV-positive patients treated with HAART increased, reaching 84% in 2010, all-cause mortality decreased, and cancer remained rare. However, almost all patients who died during the study seemed to be diagnosed at a late stage of the disease, emphasizing the need for earlier diagnosis of HIV in Algeria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.179521","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:22:30Z","timestamp":1469510550000},"page":"576-581","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cancer incidence and all-cause mortality in HIV-positive patients in Northeastern Algeria before and during the era of highly active antiretroviral therapy"],"prefix":"10.4103","volume":"12","author":[{"given":"Karima","family":"Chaabna","sequence":"first","affiliation":[{"name":"Section of Cancer Information, International Agency for Research on Cancer, Lyon, France"},{"name":"Section of Cancer Information, University of Lyon, University of Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Newton","sequence":"additional","affiliation":[{"name":"Section of Cancer Information, International Agency for Research on Cancer, Lyon, France"},{"name":"MRC\/UVRI Research Unit on AIDS, Entebbe, Uganda"},{"name":"Department of Health Sciences, University of York, York, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Vanhems","sequence":"additional","affiliation":[{"name":"Section of Cancer Information, University of Lyon, University of Lyon, France"},{"name":"Department of Hygiene, Epidemiology and Prevention, Edouard Herriot Hospital, Civil Hospital of Lyon, Lyon, France"},{"name":"Laboratory of Epidemiology and Public Health, CNRS, UMR 5558, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maamar","family":"Laouar","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Durban Hospital, University Teaching Hospital, 23000 Annaba, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Forman","sequence":"additional","affiliation":[{"name":"Section of Cancer Information, International Agency for Research on Cancer, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahira","family":"Boudiaf","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Durban Hospital, University Teaching Hospital, 23000 Annaba, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Soerjomataram","sequence":"additional","affiliation":[{"name":"Section of Cancer Information, International Agency for Research on Cancer, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"R3-20260109","author":"Touaibia","year":"2011","journal-title":"UNGAS. 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Algeria: 5th National Days of Infectious Disease Prevention"},{"key":"R20-20260109","author":"Abdennour","year":"2012","journal-title":"Enqu\u00eate sur le niveau de connaissances des jeunes de la Wilaya de Constantine sur l'infection VIH\/SIDA. Algeria: 5th National Days of Infectious Disease Prevention"},{"key":"R21-20260109","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.respe.2008.05.023","article-title":"Seroprevalence of HIV infection in pregnant women in the Annaba region (Algeria)","volume":"56","author":"Aidaoui","year":"2008","journal-title":"Rev Epidemiol Sante Publique"},{"key":"R23-20260109","doi-asserted-by":"crossref","first-page":"e1000414","DOI":"10.1371\/journal.pmed.1000414","article-title":"A surprising prevention success: Why did the HIV epidemic decline in Zimbabwe?","volume":"8","author":"Halperin","year":"2011","journal-title":"PLoS Med"},{"key":"R26-20260109","first-page":"CD003510","article-title":"Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection","volume":"7","author":"Siegfried","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"R27-20260109","author":"Lacheheb","year":"2007","journal-title":"Clinica. management of HIV\/AIDS in Algeria: Experience of Setif Reference Center. Algeria: 1st Meeting Rennes-S\u00e9tif"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201612020-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:56Z","timestamp":1786647716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201612020-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.179521","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]}}}