{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:43Z","timestamp":1786649803594,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>\n                    Carcinoma ex pleomorphic adenoma (Ca ex PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma. The most common histological subtype is adenocarcinoma, not otherwise specified, salivary duct carcinoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma (ACC). Few case reports of\n                    <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                    dedifferentiation in ACC are there in the literature, mostly involving minor salivary glands. The dedifferentiated adenoid cystic carcinoma arising in a pleomorphic adenoma of the parotid gland has not been reported earlier. The present case highlights this rare histological subtype seen in Ca ex PA and the role of extensive histopathological examination and immunohistochemistry.\n                  <\/jats:p>","DOI":"10.4103\/0973-1482.179522","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T08:26:37Z","timestamp":1528791997000},"page":"706-708","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid"],"prefix":"10.4103","volume":"14","author":[{"given":"Minakshi","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajwala","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12105-011-0281-z","article-title":"Carcinoma ex pleomorphic adenoma: A comprehensive review of clinical, pathological and molecular data","volume":"6","author":"Antony","year":"2012","journal-title":"Head Neck Pathol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12105-009-0108-3","article-title":"Adenoid cystic carcinoma ex pleomorphic adenoma of the parotid gland","volume":"3","author":"Ide","year":"2009","journal-title":"Head Neck Pathol"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s12105-009-0122-5","article-title":"High grade transformation in adenoid cystic carcinoma of the parotid: Report of a case with cytologic, histologic and immunohistochemical study","volume":"3","author":"Malhotra","year":"2009","journal-title":"Head Neck Pathol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1053\/hupa.2001.25000","article-title":"Carcinoma ex pleomorphic adenoma: Pathologic analysis of 73 cases","volume":"32","author":"Lewis","year":"2001","journal-title":"Hum Pathol"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00000478-199904000-00012","article-title":"Dedifferentiation in adenoid cystic carcinoma of salivary gland: An uncommon complication associated with an accelerated clinical course","volume":"23","author":"Cheuk","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"R6-20260109","first-page":"325965","article-title":"Current concepts on dedifferentiation\/high-grade transformation in salivary gland tumors","volume":"2011","author":"Costa","year":"2011","journal-title":"Patholog Res Int"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/PAP.0b013e318202645a","article-title":"Histologic grading and prognostic biomarkers in salivary gland carcinomas","volume":"18","author":"Seethala","year":"2011","journal-title":"Adv Anat Pathol"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/01.MP.0000097366.88165.08","article-title":"Dedifferentiated adenoid cystic carcinoma: A clinicopathologic study of 6 cases","volume":"16","author":"Nagao","year":"2003","journal-title":"Mod Pathol"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.humpath.2009.12.011","article-title":"Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: A clinicopathologic study of 43 cases","volume":"41","author":"Katabi","year":"2010","journal-title":"Hum Pathol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201814030-00045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:35Z","timestamp":1786647515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201814030-00045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.179522","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}