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Hence, the study aims at reviewing studies done on various etiological factors leading to its onset. Their analysis may serve as an adjunct in defining the broad spectrum of the causation of this potentially malignant disorder.<\/jats:p>","DOI":"10.4103\/0973-1482.179524","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T13:00:36Z","timestamp":1767790836000},"page":"399-405","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["An update on studies on etiological factors, disease progression, and malignant transformation in oral submucous fibrosis"],"prefix":"10.4103","volume":"13","author":[{"given":"Samiha","family":"Bari","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Metgud","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zankhana","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddh","family":"Tak","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Udaipur, Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5005\/jp-journals-10011-1254","article-title":"Classification System For Oral Submucous Fibrosis","volume":"24","author":"More","year":"2012","journal-title":"J Indian Acad Oral Med Radiol"},{"key":"R2-20260109","first-page":"106","article-title":"Collagenase activity in oral submucous fibrosis","volume":"16","author":"Shieh","year":"1992","journal-title":"Proc Natl Sci Counc Repub China B"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1601-0825.2006.01272.x","article-title":"Increased plasminogen activator inhibitor-1\/tissue type plasminogen activator ratio in oral submucous fibrosis","volume":"13","author":"Yang","year":"2007","journal-title":"Oral Dis"},{"key":"R4-20260109","first-page":"735","article-title":"Oral submucous fibrosis, a clinically benign but potentially malignant disease: Report of 3 cases and review of the literature","volume":"74","author":"Auluck","year":"2008","journal-title":"J Can Dent Assoc"},{"key":"R5-20260109","first-page":"39","article-title":"Oral submucous fibrosis: Current concepts in etioathogenesis","volume":"1","author":"Gupta","year":"2008","journal-title":"Peoples J Sci Res"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jobcr.2013.10.005","article-title":"Prevalence of oral submucous fibrosis among habitual gutkha and areca nut chewers in Moradabad district","volume":"4","author":"Nigam","year":"2014","journal-title":"J Oral Biol Craniofac Res"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5005\/jp-journals-10011-1249","article-title":"Prevalence of oral submucous fibrosis in patients visiting dental college in rural area of Jaipur, Rajasthan","volume":"24","author":"Sharma","year":"2012","journal-title":"J Indian Acad Oral Med Radiol"},{"key":"R8-20260109","article-title":"Malignant Conversion of Oral Submucous Fibrosis in Surgically Treated Case","volume":"8","author":"Arora","year":"2014","journal-title":"J Clin Diagn Res"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1601-0825.1997.tb00054.x","article-title":"Oral submucous fibrosis: An expert symposium","volume":"3","author":"Meghji","year":"1997","journal-title":"Oral Dis"},{"key":"R10-20260109","article-title":"Betel-quid and Areca-nut Chewing and Some Areca-nut-derived Nitrosamines. 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