{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:16Z","timestamp":1786650076763,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Esophageal squamous cell carcinoma (ESCC) is considered as the seventh most common cancer worldwide, and the second prevalent malignancy in the north of Iran. A subfamily group of tumor-specific antigens, commonly specified as cancer\/testis antigens (CTAs), are expressed restrictedly in testis, ovary, and placenta. Melanoma-associated antigen A4 (MAGEA4) as a CTA is overexpressed in a variety of cancers. Expressional analysis of MAGEA4 protein in ESCC may be useful to investigate its clinical relevance leading to effective improvements in ESCC diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Fifty-six ESCC patients with no preoperative therapeutic circumstance such as radiotherapy or chemotherapy were analyzed to explore the protein expression level of MAGEA4 using immunohistochemistry assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      MAGEA4 overexpression was detected in 66% of ESCC samples showing strong nuclear and cytoplasmic staining compared to the normal epithelium. There were significant correlations between MAGEA4 protein expression and depth of tumor invasion (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.019), and the number of involved lymph nodes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Because of the significant correlation of MAGEA4 and indices of poor prognosis, the role of this CTA may be confirmed in ESCC aggressiveness and metastasis. Therefore, MAGEA4 may be a promising therapeutic candidate for suppressing ESCC aggressiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.183180","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:03:38Z","timestamp":1531991018000},"page":"1059-1064","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Investigation of melanoma-associated antigen A4 cancer\/testis antigen clinical relevance in esophageal squamous cell carcinoma"],"prefix":"10.4103","volume":"14","author":[{"given":"Soodabeh Abbasi","family":"Sani","sequence":"first","affiliation":[{"name":"Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran"},{"name":"Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Forghanifard","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorieh","family":"Sharifi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ghaem Hospital, School of Medicine, Mashhad university of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnaz Hashemi","family":"Bidokhti","sequence":"additional","affiliation":[{"name":"Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran"},{"name":"Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Jian","family":"Bagherpoor","sequence":"additional","affiliation":[{"name":"Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Abbaszadegan","sequence":"additional","affiliation":[{"name":"Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"R1-20260109","first-page":"463","article-title":"A cancer-array approach elucidates the immune escape mechanism and defects in the dna repair system in esophageal squamous cell carcinoma","volume":"16","author":"Dadkhah","year":"2013","journal-title":"Archives of Iranian 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