{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:05Z","timestamp":1786649885678,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to examine the role of sentinel lymph node biopsy (SLNB) on long-term disease outcome in patients with intermediate-thickness primary cutaneous melanomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Forty patients with intermediate-thickness melanomas, defined as 1.0\u20134.0 mm, underwent SLNB between 1998 and 2011. The disease-free survival (DFS), overall survival (OS) and prognostic factors were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Median age was 53 years (range: 24\u201374 years). Median Breslow thickness was 2.8 mm (range: 1.0\u20134.0 mm) and 27.5% were ulcerated melanomas. Median follow-up time was 70 months (range: 23\u2013168 months). The number of patients with sentinel lymph node (SLN)-positive was 9 (22.5%) and completion lymph node dissection was performed in all of these patients. Ten patients (25%) developed distant and locoregional recurrence; 4 in the SLN-positive group (4\/9; 45%) and 6 in the SLN-negative group (6\/31; 19%), P &lt; 0.042. In the SLN-negative group, one patient developed regional node recurrence; false-negative rate was 10%. SLN positivity and ulceration were independent prognostic factors for DFS in multivariate analysis (hazard ratio [HR] of 4.6, and 10.5, respectively; P &lt; 0.011). For OS SLN positivity, ulceration and Breslow thickness were found to be the significant prognostic factors (HR of 5.4, 8.5 and 5.0, respectively; P &lt; 0.024). Ten-year DFS and OS for SLN-negative and SLN-positive patients were 71%, 47% (P &lt; 0.003), and 80%, 55% (P &lt; 0.005), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study shows that survival rates are worse in the SLN-positive patients according to the long-term follow-up data. Ulceration and Breslow thickness also have significant effects on long-term survival in patients with intermediate-thickness primary cutaneous melanomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.186694","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:22:30Z","timestamp":1469510550000},"page":"840-844","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Sentinel lymph node status affects long-term survival in patients with intermediate-thickness melanoma"],"prefix":"10.4103","volume":"12","author":[{"given":"Kaptan","family":"G\u00fclben","sequence":"first","affiliation":[{"name":"Department of Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U\u011fur","family":"Berbero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Alt\u0131nyollar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Bay\u0131nd\u0131r Hospital Kavakl\u0131dere, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"K\u0131na\u015f","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsun Training and Research Hospital, Samsun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevim","family":"Turanl\u0131","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ankara Oncology Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"R1-20260109","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1200\/JCO.2009.27.1627","article-title":"Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: Comparison of nodal micrometastases versus macrometastases","volume":"28","author":"Balch","year":"2010","journal-title":"J Clin Oncol"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1200\/JCO.2011.40.3519","article-title":"Sentinel lymph node biopsy for melanoma: American Society of Clinical Oncology and Society of Surgical Oncology joint clinical practice guideline","volume":"30","author":"Wong","year":"2012","journal-title":"J Clin Oncol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00008390-199508000-00008","article-title":"Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes","volume":"5","author":"Thompson","year":"1995","journal-title":"Melanoma Res"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa060992","article-title":"Sentinel-node biopsy or nodal observation in melanoma","volume":"355","author":"Morton","year":"2006","journal-title":"N Engl J Med"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00000658-199910000-00001","article-title":"Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: A multicenter trial. 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