{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:52Z","timestamp":1786649812397,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Malignant thyroid tumors of follicular origin comprise a spectrum, with the indolent well-differentiated thyroid carcinoma (WDTC) at one end and lethal anaplastic thyroid carcinoma (ATC) at the other. Poorly differentiated thyroid carcinoma (PDTC) lies intermediately between WDTC and ATC in terms of morphology and prognostic standpoint. This thyroglobulin producing neoplasm accounts for 4\u20137% of all thyroid malignancies. PDTC has been controversial due to lack of defined diagnostic criteria. We hereby report a case of PDTC in a 42-year-old female presenting with neck swelling, pain, and dysphagia for 10 months. She was diagnosed as colloid goiter on fine-needle aspiration cytology. On imaging, a large complex thyroid with central neck nodes was seen. Total thyroidectomy and central neck node dissection were done. Based on the morphology, immunostaining, and the diagnostic criteria, a diagnosis of PDTC was made. PDTC is a diagnostic challenge due to its rarity and previous equivocal diagnostic criteria.<\/jats:p>","DOI":"10.4103\/0973-1482.187239","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:03:38Z","timestamp":1531991018000},"page":"1142-1144","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Poorly differentiated carcinoma of thyroid: Case report of an uncommon entity"],"prefix":"10.4103","volume":"14","author":[{"given":"Shaan","family":"Khetrapal","sequence":"first","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safia","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Jetley","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeba","family":"Jairajpuri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"R1-20260109","first-page":"467","article-title":"The clinical course of poorly differentiated thyroid carcinoma (Insular carcinoma) \u2013 Own observations","volume":"61","author":"Walczyk","year":"2010","journal-title":"Pol J Endocrinol"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/1097-0142(19831115)52:10<1849::AID-CNCR2820521015>3.0.CO;2-X","article-title":"Poorly differentiated carcinoma of the thyroid. A clinicopathologic entity for a high-risk group of papillary and follicular carcinomas","volume":"52","author":"Sakamoto","year":"1983","journal-title":"Cancer"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/PCR.0b013e3181c75937","article-title":"Poorly differentiated carcinoma of the thyroid gland","volume":"14","author":"Volante","year":"2009","journal-title":"Pathol Case Rev"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1097\/PAS.0b013e3180309e6a","article-title":"Poorly differentiated thyroid carcinoma: The Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach","volume":"31","author":"Volante","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/107327480601300206","article-title":"Poorly differentiated and anaplastic thyroid cancer","volume":"13","author":"Patel","year":"2006","journal-title":"Cancer Control"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/cncr.20087","article-title":"Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: A clinicopathologic study of 183 patients","volume":"100","author":"Volante","year":"2004","journal-title":"Cancer"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/0970-9371.93237","article-title":"Poorly differentiated (insular) thyroid carcinoma arising in a long-standing colloid goitre: A cytological dilemma","volume":"29","author":"Kini","year":"2012","journal-title":"J Cytol"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/cncr.22913","article-title":"Thyroid carcinomas with a variable insular component: Prognostic significance of histopathologic patterns","volume":"110","author":"Rufini","year":"2007","journal-title":"Cancer"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12022-008-9023-5","article-title":"A practical diagnostic approach to solid\/trabecular nodules in the thyroid","volume":"19","author":"Volante","year":"2008","journal-title":"Endocr Pathol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201814050-00042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:58:41Z","timestamp":1786647521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201814050-00042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.187239","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}