{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:12Z","timestamp":1786650072760,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to demonstrate the effects of clinical evaluations as well as biopsy characteristics in terms of lymph node involvement (LNI) despite the small number of patients in our study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 221 patients who underwent radical prostatectomy (RP) and extended pelvic lymph node dissection (ePLND) in our clinic between 2010 and 2015 and who met the inclusion criteria were enrolled in our study group. All of the patients were evaluated in terms of age, prostate-specific antigen (PSA) value before transrectal ultrasound-guided prostate biopsy (TRUSPB), digital rectal examination, Gleason score (GS) on TRUSPB, percentage of positive cores on TRUSPB, total number of positive cores, highest percentage of cancer in positive cores, and number of lymph nodes removed at RP. Pathological examination of the data of RP specimens, PSA values in follow-up after surgery, and follow-up periods was recorded. The TNM 2009 classification was used for staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the evaluation of LNI risk, as regards the assessment of predictors and outcomes with respect to the univariate and multivariate analyses, LNI was found in the univariate analysis to be associated with GS, clinical stage, number of lymph nodes removed according to the D'Amico risk classification. In the multivariate analysis, however, the number of lymph nodes removed was found significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Risk stratification should be considered in patients with prostate cancer while selecting the patients who would undergo pelvic lymphadenectomy. In addition, ePLND should be performed to patients undergoing lymphadenectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.187286","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:03:38Z","timestamp":1531991018000},"page":"1094-1098","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["The factors that affect the prediction of lymph node metastasis in prostate cancer"],"prefix":"10.4103","volume":"14","author":[{"given":"Hakan","family":"Turk","sequence":"first","affiliation":[{"name":"Department of Urology, Faculty of Medicine, Evliya Celebi Training and Research Hospital, Dumlupinar University, K\u00fctahya 43100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0131tk\u0131","family":"\u00dcn","sequence":"additional","affiliation":[{"name":"Department of Urology, Katip \u00c7elebi University Atat\u00fcrk Training and Research Hospital, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Urology, Can Hospital, Manisa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Cinkaya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Evliya Celebi Training and Research Hospital, Dumlupinar University, K\u00fctahya 43100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmi","family":"Kodaz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Faculty of Medicine, Evliya Celebi Training and Research Hospital, Dumlupinar University, K\u00fctahya 43100, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruh","family":"Zorlu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tepecik Training and Research Hospital, \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"R1-20260109","first-page":"106","article-title":"Cancer statistics, 2006","volume":"56","author":"Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0090-4295(01)01441-8","article-title":"Contemporary update of prostate cancer staging nomograms (Partin Tables) for the new millennium","volume":"58","author":"Partin","year":"2001","journal-title":"Urology"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0022-5347(05)67809-3","article-title":"Prostate cancer detection at low prostate specific antigen","volume":"163","author":"Schr\u00f6der","year":"2000","journal-title":"J Urol"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.eururo.2013.11.002","article-title":"EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer","volume":"65","author":"Heidenreich","year":"2014","journal-title":"Eur Urol"},{"issue":"3 Pt 2","key":"R7-20260109","first-page":"993","article-title":"The use and accuracy of cross-sectional imaging and fine needle aspiration cytology for detection of pelvic lymph node metastases before radical prostatectomy","volume":"153","author":"Wolf","year":"1995","journal-title":"J Urol"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.rcl.2006.07.008","article-title":"MR imaging and MR spectroscopy in prostate cancer management","volume":"44","author":"Katz","year":"2006","journal-title":"Radiol Clin North Am"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/jama.285.5.562","article-title":"Advances in biomedical imaging","volume":"285","author":"Tempany","year":"2001","journal-title":"JAMA"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.eururo.2006.01.043","article-title":"Validation of a nomogram predicting the probability of lymph node invasion among patients undergoing radical prostatectomy and an extended pelvic lymphadenectomy","volume":"49","author":"Briganti","year":"2006","journal-title":"Eur Urol"},{"key":"R11-20260109","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.eururo.2007.01.108","article-title":"Percentage of positive biopsy cores can improve the ability to predict lymph node invasion in patients undergoing radical prostatectomy and extended pelvic lymph node dissection","volume":"51","author":"Briganti","year":"2007","journal-title":"Eur Urol"},{"key":"R12-20260109","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijrobp.2008.04.082","article-title":"External validation of the updated partin tables in a cohort of French and Italian men","volume":"73","author":"Bhojani","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"R13-20260109","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1158\/1078-0432.CCR-07-0901","article-title":"Use of preoperative plasma endoglin for prediction of lymph node metastasis in patients with clinically localized prostate cancer","volume":"14","author":"Karam","year":"2008","journal-title":"Clin Cancer Res"},{"key":"R14-20260109","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2214\/AJR.04.1682","article-title":"Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancer","volume":"186","author":"Wang","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"R15-20260109","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0022-5347(05)64055-4","article-title":"Randomized prospective evaluation of extended versus limited lymph node dissection in patients with clinically localized prostate cancer","volume":"169","author":"Clark","year":"2003","journal-title":"J Urol"},{"key":"R16-20260109","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/S0022-5347(01)64161-2","article-title":"Laparoscopic pelvic lymph node dissection for prostate cancer: Comparison of the extended and modified techniques","volume":"158","author":"Stone","year":"1997","journal-title":"J Urol"},{"key":"R17-20260109","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ncpuro0558","article-title":"An extended pelvic lymph-node dissection should be performed in most patients if radical prostatectomy is truly indicated","volume":"3","author":"Burkhard","year":"2006","journal-title":"Nat Clin Pract Urol"},{"key":"R18-20260109","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.urology.2006.09.008","article-title":"Critical assessment of ideal nodal yield at pelvic lymphadenectomy to accurately diagnose prostate cancer nodal metastasis in patients undergoing radical retropubic prostatectomy","volume":"69","author":"Briganti","year":"2007","journal-title":"Urology"},{"key":"R19-20260109","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0022-5347(05)65177-4","article-title":"Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: High incidence of lymph node metastasis","volume":"167","author":"Heidenreich","year":"2002","journal-title":"J Urol"},{"key":"R20-20260109","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0022-5347(05)64670-8","article-title":"Is a limited lymph node dissection an adequate staging procedure for prostate cancer?","volume":"168","author":"Bader","year":"2002","journal-title":"J Urol"},{"key":"R21-20260109","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1569-9056(04)90059-0","article-title":"Lymph nodes metastases in patients with prostate cancer and with a PSA<10 ng\/ml","volume":"3","author":"Schuhmacher","year":"2004","journal-title":"Eur Urol Suppl"},{"key":"R22-20260109","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eururo.2004.07.017","article-title":"Is there a need for pelvic lymph node dissection in low risk prostate cancer patients prior to definitive local therapy?","volume":"47","author":"Weckermann","year":"2005","journal-title":"Eur Urol"},{"key":"R23-20260109","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0022-5347(01)63234-8","article-title":"Systematic sextant biopsies improve preoperative prediction of pelvic lymph node metastases in patients with clinically localized prostatic carcinoma","volume":"159","author":"Conrad","year":"1998","journal-title":"J Urol"},{"key":"R24-20260109","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1097\/01.ju.0000051400.85694.bb","article-title":"The SEARCH Database Study Group. Percent of prostate needle biopsy cores with cancer is significant independent predictor of prostate specific antigen recurrence following radical prostatectomy: Results from SEARCH database","volume":"169","author":"Freedland","year":"2003","journal-title":"J Urol"},{"key":"R25-20260109","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1464-410X.2010.09485.x","article-title":"Percentage of positive biopsies predicts lymph node involvement in men with low-risk prostate cancer undergoing radical prostatectomy and extended pelvic lymphadenectomy","volume":"107","author":"Heidenreich","year":"2011","journal-title":"BJU Int"},{"key":"R26-20260109","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4103\/0974-7796.152118","article-title":"Prostate-specific antigen density as a parameter for the prediction of positive lymph nodes at radical prostatectomy","volume":"7","author":"Yiakoumos","year":"2015","journal-title":"Urol Ann"},{"key":"R27-20260109","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.juro.2007.10.060","article-title":"Prostate cancer volume at biopsy predicts clinically significant upgrading","volume":"179","author":"Dong","year":"2008","journal-title":"J Urol"},{"key":"R28-20260109","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.juro.2006.09.053","article-title":"Limited pelvic lymph node dissection at the time of radical prostatectomy does not affect 5-year failure rates for low, intermediate and high risk prostate cancer: Results from CaPSURE","volume":"177","author":"Berglund","year":"2007","journal-title":"J Urol"},{"key":"R29-20260109","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.eururo.2007.04.020","article-title":"Anatomical extent of pelvic lymphadenectomy in patients undergoing radical prostatectomy","volume":"52","author":"Heidenreich","year":"2007","journal-title":"Eur Urol"},{"key":"R30-20260109","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.eururo.2006.01.061","article-title":"Is pelvic lymph node dissection necessary in patients with a serum PSA<10ng\/ml undergoing radical prostatectomy for prostate cancer?","volume":"50","author":"Schumacher","year":"2006","journal-title":"Eur Urol"},{"key":"R31-20260109","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0022-5347(05)00685-3","article-title":"The association between total and positive lymph node counts, and disease progression in clinically localized prostate cancer","volume":"175","author":"Masterson","year":"2006","journal-title":"J Urol"},{"key":"R32-20260109","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/01.ju.0000155533.93528.4c","article-title":"The extent of lymphadenectomy for PTXNO prostate cancer does not effect prostate cancer outcome in the prostate specific antigen era","volume":"173","author":"DiMarco","year":"2005","journal-title":"J Urol"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201814050-00032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:45Z","timestamp":1786647705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201814050-00032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.187286","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}