{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:13:48Z","timestamp":1786738428956,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>The early diagnosis of very rare nasopharyngeal carcinoma (NPC) is so difficult, to surrounded by structures such as the orbital skull base. With the invasion of the disease, the symptoms are manifested in different ways so that it may be confusion and delay in diagnosis and treatment in this situation. Including otological symptoms (serous otitis media), Gradenigo's syndrome is a rare clinical condition. The majority of published cases involve children, and the most common etiology is otitis media. We report a case of a diabetic man who presented with repeating Gradenigo's syndrome symptoms due to NPC.<\/jats:p>","DOI":"10.4103\/0973-1482.189223","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:03:38Z","timestamp":1531991018000},"page":"1152-1153","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Recurrent petrositis due to nasopharyngeal carcinoma in an adult patient: Gradenigo's syndrome"],"prefix":"10.4103","volume":"14","author":[{"given":"Asude","family":"Aksoy","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Medical Faculty, Firat University, Elazig, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuman Orhan","family":"Varoglu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medeniyet University, Medical Faculty, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"R1-20260109","volume":"1","author":"Phister","year":"2016","journal-title":"Head and neck cancers: National Comprehensive Cancer Network (NCCN): Clinical Practice Guideles in Oncology"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jemermed.2004.03.014","article-title":"Gradenigo syndrome: A case report and review of a rare complication of otitis media","volume":"27","author":"Sherman","year":"2004","journal-title":"J Emerg Med"},{"key":"R4-20260109","doi-asserted-by":"crossref","DOI":"10.1136\/bcr.03.2011.3978","article-title":"Conservative management of Gradenigo's syndrome in a child","volume":"2011","author":"Rossor","year":"2011","journal-title":"BMJ Case Rep"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/1752-1947-8-217","article-title":"Gradenigo's syndrome secondary to chronic otitis media on a background of previous radical mastoidectomy: A case report","volume":"8","author":"Plodpai","year":"2014","journal-title":"J Med Case Rep"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/BF02012150","article-title":"Gradenigo syndrome: A case report","volume":"23","author":"Tutuncuoglu","year":"1993","journal-title":"Pediatr Radiol"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1007\/s00106-004-1163-4","article-title":"Gradenigo syndrome \u2013 Still a threatening complication of otitis media","volume":"53","author":"Bloching","year":"2005","journal-title":"HNO"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1258\/0022215011907299","article-title":"Recurrent temporal petrositis","volume":"115","author":"Al-Ammar","year":"2001","journal-title":"J Laryngol Otol"},{"key":"R9-20260109","first-page":"169","article-title":"Carcinoma of the nasopharynx, radiotherapy, otitis, labyrinthitis, inflammation of the petrous bone, meningitis","volume":"26","author":"Pomar Blanco","year":"1999","journal-title":"An Otorrinolaringol Ibero Am"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF01105779","article-title":"Importance of cranial nerve involvement in nasopharyngeal carcinoma. 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