{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:47Z","timestamp":1786650047659,"version":"build-2736575974"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The relation between Beh\u00e7et's disease (BD) and breast cancer (BC) is unclear. Our purpose is to investigate whether BD has an important effect on BC or vice versa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>A total of 12 female BC patients with a diagnosis of BD were identified from a cohort including 5050 BC patients. The demographic data of the selected patients including previous chemotherapy (CT), radiotherapy (RT), hormonal therapy (HT), drugs used for BD, history of thrombotic events, and overall survival were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The rate of BD in the entire cohort was found to be 0.25% (12\/4800), and all had early BC at the time of BC diagnosis, with a median age of 47 years (range: 38\u201351). All patients underwent curative surgery for BC. In the adjuvant setting, CT, RT, and HT were administered in 11 (91%), 10 (83.4%), and 9 (75%) patients, respectively. All patients received acetylsalicylic acid and colchicine for BD. No serious adverse event associated with BC and\/or BD was observed. Clinical symptoms in 11 patients with BD were observed to be improved following the BC treatment. Only one patient developed disease progression and then expired.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Unlike the natural behavior of BD, which is well-defined to have an increased risk of thrombosis, BC patients with BD in this study did not have any adverse event. However, due to small sample size, it is difficult to drive any definite conclusion regarding the relation between these two pathologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.189249","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T09:03:38Z","timestamp":1531991018000},"page":"1184-1190","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Beh\u00e7et's disease and breast cancer: A case series study"],"prefix":"10.4103","volume":"14","author":[{"given":"Fatih","family":"Karatas","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Diskapi Yildirim Beyazit Education and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Diskapi Yildirim Beyazit Education and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Aytekin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Ankara Numune Education and Training Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokmen Umut","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozturk","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Ozisik","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sercan","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadri","family":"Altundag","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"R1-20260109","first-page":"1119","article-title":"Multiple associations between a broad spectrum of autoimmune diseases, chronic inflammatory diseases and cancer","volume":"32","author":"Franks","year":"2012","journal-title":"Anticancer Res"},{"key":"R2-20260109","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/ard.60.5.433","article-title":"Cancer and autoimmunity: Autoimmune and rheumatic features in patients with malignancies","volume":"60","author":"Abu-Shakra","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"R3-20260109","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s100670170036","article-title":"Malignancy in Beh\u00e7et's disease: A report of 13 cases and a review of the literature","volume":"20","author":"Cengiz","year":"2001","journal-title":"Clin Rheumatol"},{"key":"R4-20260109","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.autrev.2013.09.006","article-title":"Breast cancer in systemic sclerosis: Results of a cross-linkage of an Italian rheumatologic center and a population-based cancer registry and review of the literature","volume":"13","author":"Colaci","year":"2014","journal-title":"Autoimmun Rev"},{"key":"R5-20260109","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/1097-0142(19910801)68:3<502::AID-CNCR2820680310>3.0.CO;2-V","article-title":"Breast conservation therapy. Severe breast fibrosis after radiation therapy in patients with collagen vascular disease","volume":"68","author":"Robertson","year":"1991","journal-title":"Cancer"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"8706","DOI":"10.1073\/pnas.1407307111","article-title":"HLA-B*51 the primary risk in Beh\u00e7et disease","volume":"111","author":"Wallace","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ncprheum0436","article-title":"Beh\u00e7et's syndrome: Disease manifestations, management, and advances in treatment","volume":"3","author":"Yazici","year":"2007","journal-title":"Nat Clin Pract Rheumatol"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1039\/C5MD00320B","article-title":"Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties","volume":"6","author":"Sitnikov","year":"2015","journal-title":"Medchemcomm"},{"key":"R9-20260109","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/1756-185X.12269","article-title":"Behcet's disease associated with malignancy: A report of 41 Chinese cases","volume":"17","author":"Lin","year":"2014","journal-title":"Int J Rheum Dis"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/tbj.12320","article-title":"Behcet's disease and breast cancer","volume":"20","author":"Roach","year":"2014","journal-title":"Breast J"},{"issue":"4","key":"R11-20260109","first-page":"S35","article-title":"Beh\u00e7et's disease associated with malignancies. Report of two cases and review of the literature","volume":"23","author":"Kaklamani","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"R12-20260109","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3899\/jrheum.140770","article-title":"Risk of overall and site-specific cancers in Beh\u00e7et disease: A nationwide population-based study in Taiwan","volume":"42","author":"Wang","year":"2015","journal-title":"J Rheumatol"},{"key":"R13-20260109","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.thromres.2005.10.015","article-title":"Chemotherapy-induced thrombosis","volume":"118","author":"Haddad","year":"2006","journal-title":"Thromb Res"},{"key":"R14-20260109","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/FJC.0b013e3181d263f7","article-title":"Paclitaxel potentiates inflammatory cytokine-induced prothrombotic molecules in endothelial cells","volume":"55","author":"Wood","year":"2010","journal-title":"J Cardiovasc Pharmacol"},{"key":"R15-20260109","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1158\/1535-7163.MCT-06-0154","article-title":"Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway","volume":"5","author":"Woodley-Cook","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"R16-20260109","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/toxsci\/kfr222","article-title":"Doxorubicin-induced platelet procoagulant activities: An important clue for chemotherapy-associated thrombosis","volume":"124","author":"Kim","year":"2011","journal-title":"Toxicol Sci"},{"key":"R17-20260109","first-page":"887","article-title":"Venous thrombosis as a side effect of tamoxifen treatment","volume":"68","author":"Lipton","year":"1984","journal-title":"Cancer Treat Rep"},{"key":"R18-20260109","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1200\/JCO.1991.9.2.286","article-title":"Venous and arterial thrombosis in patients who received adjuvant therapy for breast cancer","volume":"9","author":"Saphner","year":"1991","journal-title":"J Clin Oncol"},{"key":"R19-20260109","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1046\/j.1365-2141.2003.03976.x","article-title":"Effect of tamoxifen on venous thrombosis risk factors in women without cancer: The breast cancer prevention trial","volume":"120","author":"Cushman","year":"2003","journal-title":"Br J Haematol"},{"key":"R20-20260109","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.2165\/00003495-200666130-00005","article-title":"Cardiovascular health and aromatase inhibitors","volume":"66","author":"Pritchard","year":"2006","journal-title":"Drugs"},{"key":"R22-20260109","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jvs.2011.07.049","article-title":"Management and prognosis of nonpulmonary large arterial disease in patients with Beh\u00e7et disease","volume":"55","author":"Tuzun","year":"2012","journal-title":"J Vasc Surg"},{"key":"R23-20260109","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/2040622314523062","article-title":"Update on the therapy of Beh\u00e7et disease","volume":"5","author":"Saleh","year":"2014","journal-title":"Ther Adv Chronic Dis"},{"key":"R25-20260109","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0140-6736(94)92150-4","article-title":"Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease","volume":"343","author":"Connell","year":"1994","journal-title":"Lancet"},{"key":"R26-20260109","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1212\/WNL.46.6.1607","article-title":"Risk of cancer from azathioprine therapy in multiple sclerosis: A case-control study","volume":"46","author":"Confavreux","year":"1996","journal-title":"Neurology"},{"key":"R27-20260109","article-title":"Immunosuppression and Cancer","year":"1973","journal-title":"Transplantation Proceedings"},{"key":"R29-20260109","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Beh\u00e7et's disease","volume":"341","author":"Sakane","year":"1999","journal-title":"N Engl J Med"},{"key":"R30-20260109","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-4362.2003.01893.x","article-title":"Prevalence of Beh\u00e7et's disease in Istanbul, Turkey","volume":"42","author":"Azizlerli","year":"2003","journal-title":"Int J Dermatol"},{"key":"R31-20260109","first-page":"252","article-title":"Cancer treatment and survivorship statistics, 2014","volume":"64","author":"DeSantis","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"R32-20260109","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.coi.2007.01.001","article-title":"Humoral immunity, inflammation and cancer","volume":"19","author":"Tan","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"R33-20260109","first-page":"753","article-title":"Autoantibodies, autoimmunity and cancer (review)","volume":"5","author":"Tomer","year":"1998","journal-title":"Oncol Rep"},{"key":"R34-20260109","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/bjd.12111","article-title":"Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: A survey among 1307 patients and their partners","volume":"168","author":"Teulings","year":"2013","journal-title":"Br J Dermatol"},{"key":"R35-20260109","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10549-014-3258-2","article-title":"Autoimmune diseases and breast cancer recurrence: A Danish nationwide cohort study","volume":"149","author":"Lietzen","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"R36-20260109","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ygyno.2012.07.100","article-title":"Effect of autoimmune diseases on risk and survival in female cancers","volume":"127","author":"Hemminki","year":"2012","journal-title":"Gynecol Oncol"},{"key":"R37-20260109","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/sj.bjc.6604906","article-title":"Breast cancer risk in elderly women with systemic autoimmune rheumatic diseases: A population-based case-control study","volume":"100","author":"Gadalla","year":"2009","journal-title":"Br J Cancer"},{"key":"R38-20260109","first-page":"892","article-title":"Colchicine semisynthetics: Chemotherapeutics for cancer?","volume":"20","author":"Sivakumar","year":"2013","journal-title":"Curr Med Chem"},{"key":"R39-20260109","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.lfs.2013.07.002","article-title":"Anti-cancer mechanisms of clinically acceptable colchicine concentrations on hepatocellular carcinoma","volume":"93","author":"Lin","year":"2013","journal-title":"Life Sci"},{"key":"R40-20260109","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.kjms.2015.01.008","article-title":"Clinically acceptable colchicine concentrations have potential for the palliative treatment of human cholangiocarcinoma","volume":"31","author":"Wu","year":"2015","journal-title":"Kaohsiung J Med Sci"},{"key":"R41-20260109","doi-asserted-by":"crossref","first-page":"e1570","DOI":"10.1097\/MD.0000000000001570","article-title":"Colchicine significantly reduces incident cancer in gout male patients: A 12-year cohort study","volume":"94","author":"Kuo","year":"2015","journal-title":"Medicine"},{"key":"R42-20260109","first-page":"71","article-title":"Beh\u00e7et's disease as a model of venous thrombosis","volume":"4","author":"La Regina","year":"2010","journal-title":"Open Cardiovasc Med J"},{"key":"R43-20260109","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.radonc.2005.12.013","article-title":"Influence of connective tissue diseases on the expression of radiation side effects: A systematic review","volume":"78","author":"H\u00f6lscher","year":"2006","journal-title":"Radiother Oncol"},{"key":"R44-20260109","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.radonc.2008.10.013","article-title":"Severe acute radiation-related skin toxicity in a breast cancer patient with Beh\u00e7et's disease","volume":"91","author":"Chargari","year":"2009","journal-title":"Radiother Oncol"},{"key":"R45-20260109","doi-asserted-by":"crossref","first-page":"E125","DOI":"10.1188\/12.CJON.E125-E132","article-title":"Chemotherapy and biotherapeutic agents for autoimmune diseases","volume":"16","author":"Zack","year":"2012","journal-title":"Clin J Oncol Nurs"}],"container-title":["Journal of Cancer Research and Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363817-201814060-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:26Z","timestamp":1786647686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363817-201814060-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4103\/0973-1482.189249","relation":{},"ISSN":["0973-1482","1998-4138"],"issn-type":[{"value":"0973-1482","type":"print"},{"value":"1998-4138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10]]}}}