{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:14Z","timestamp":1786649774444,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Aim:<\/jats:title>\n \n Various phosphonate ligands labeled with \u03b2\n \u2212<\/jats:sup>\n -emitting radionuclides have shown good efficacy for bone pain palliation. In this study, a new agent for bone pain palliation has been developed.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Samarium-153-(4-[((bis(phosphonomethyl))carbamoyl)methyl]-7,10-bis (carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (\n 153<\/jats:sup>\n Sm-BPAMD) complex was prepared using BPAMD ligand and samarium-153 chloride. The effect of various parameters on the labeling yield of\n 153<\/jats:sup>\n Sm-BPAMD including ligand concentration, pH, temperature, and reaction time were studied. Production of\n 153<\/jats:sup>\n Sm was performed at a research reactor using\n 152<\/jats:sup>\n Sm (n, \u03b3)\n 153<\/jats:sup>\n Sm nuclear reaction. The radiochemical purity of the radiolabeled complex was checked by instant thin layer chromatography. Stability studies of the complex in the final preparation and the presence of human serum were performed up to 48 h. Partition coefficient and hydroxyapatite (HA) binding of the complex were investigated and biodistribution studies using single photon emission computed tomography (SPECT) and scarification were performed after injection of the complex to wild-type mice.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n 153<\/jats:sup>\n Sm-BPAMD was prepared in a high radiochemical purity >98% and specific activity of 267 GBq\/mmol at the optimal conditions. The complex demonstrated significant stability at the room temperature and in human serum at least for 48 h. HA binding assay demonstrated that at the amount of more than 5 mg, approximately, all radiolabeled complex was bind to HA. At the pH 7.4, log P\n o<\/jats:sub>\n \/w was \u2212 1.86 \u00b1 0.02. Both SPECT and scarification showed major accumulation of the labeled compound in the bone tissue.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n \n The results show that\n 153<\/jats:sup>\n Sm-BPAMD has interesting characteristics as an agent for bone pain palliation, however, further biological studies in other mammals are still needed.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0973-1482.197534","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T07:05:09Z","timestamp":1683183909000},"page":"1117-1123","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Samarium-153-(4-[((bis (phosphonomethyl)) carbamoyl) methyl]-7,10-bis (carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid: A novel agent for bone pain palliation therapy"],"prefix":"10.4103","volume":"12","author":[{"given":"Hassan","family":"Yousefnia","sequence":"first","affiliation":[{"name":"Nuclear Science and Technology Research Institute, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Enayati","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hosntalab","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaneh","family":"Zolghadri","sequence":"additional","affiliation":[{"name":"Nuclear Science and Technology Research Institute, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bahrami-Samani","sequence":"additional","affiliation":[{"name":"Nuclear Science and Technology Research Institute, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20260109","first-page":"205","article-title":"Pathophysiology of bone metastases: How this knowledge may lead to therapeutic intervention","volume":"2","author":"Lipton","year":"2004","journal-title":"J Support Oncol"},{"key":"R3-20260109","first-page":"1031","article-title":"Samarium-153-EDTMP biodistribution and dosimetry estimation","volume":"34","author":"Eary","year":"1993","journal-title":"J Nucl Med"},{"key":"R4-20260109","first-page":"1383","article-title":"High-dose 166Ho-DOTMP in myeloablative treatment of multiple myeloma: Pharmacokinetics, biodistribution, and absorbed dose estimation","volume":"43","author":"Rajendran","year":"2002","journal-title":"J Nucl Med"},{"key":"R5-20260109","first-page":"1451","article-title":"Samarium-153-EDTMP: Pharmacokinetic, toxicity and pain response using an escalating dose schedule in treatment of metastatic bone cancer","volume":"33","author":"Farhanghi","year":"1992","journal-title":"J Nucl Med"},{"key":"R6-20260109","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.nucmedbio.2012.04.007","article-title":"(68) Ga-BPAMD: PET-imaging of bone metastases with a generator based positron emitter","volume":"39","author":"Fellner","year":"2012","journal-title":"Nucl Med Biol"},{"key":"R7-20260109","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1007\/s00259-009-1355-y","article-title":"PET\/CT imaging of osteoblastic bone metastases with (68) Ga-bisphosphonates:First human study","volume":"37","author":"Fellner","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"R8-20260109","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ejmech.2004.02.009","article-title":"Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic\/phosphonic group combinations on samarium-153 chelation capacity and stability","volume":"39","author":"Ouadi","year":"2004","journal-title":"Eur J Med Chem"},{"key":"R9-20260109","first-page":"1358","article-title":"Radiopharmaceutical therapy for palliation of bone pain from osseous metastases","volume":"45","author":"Pandit-Taskar","year":"2004","journal-title":"J Nucl Med"},{"key":"R10-20260109","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1021\/bc9900082","article-title":"Preparation and pharmacokinetics of samarium(III)-153-labeled DTPA-bis-biotin. 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