{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:11Z","timestamp":1786650071750,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We studied CXCL12-related rs18011157 polymorphism in non-Hodgkin lymphoma (NHL) patients. We also determined the effect of this polymorphism on clinical features and outcome of NHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included 90 NHL patients (54 males, 36 females) and 88 healthy controls (54 males, 34 females). CXCL12-related rs18011157 polymorphism was determined by polymerase chain reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      rs18011157 polymorphism was significantly more frequent in NHL patients with GA genotype than in healthy controls (37.8% vs. 20.5%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.011). The frequency of patients with initially high lactate dehydrogenase (LDH) level (65.8% vs. 38.5%) and extranodal involvement (61.1% vs. 43.8%) was significantly higher in the GA plus AA genotype groups when considered altogether (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and 0.09). Poor prognostic factors in univariate analysis were the presence of B symptoms, initially high International Prognostic Index (IPI), splenomegaly, nonresponse to first-line therapy, the presence of early relapse, and carrying A allele (GA plus AA genotypes). The independent prognostic factors in multivariate analysis were only early relapse and an initially high IPI score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>CXCL12 rs1801157 polymorphism which was found to be associated with extranodal involvement and increased LDH in NHL might be a marker of poor prognosis in patients with GA and AA genotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CXCL12-related rs18011517 polymorphism was more frequent in NHL patients: it might be associated with NHL pathogenesis and outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0973-1482.203596","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T07:29:50Z","timestamp":1490945390000},"page":"1075-1078","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["CXCL12 rs18011157 polymorph\u0131sm in patients w\u0131th non-Hodgkin's lymphoma: Is it associated with poor outcome?"],"prefix":"10.4103","volume":"14","author":[{"given":"Gulsum Emel","family":"Pamuk","sequence":"first","affiliation":[{"name":"Department of Hematology, Medical Faculty, Trakya University, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmi","family":"Tozk\u0131r","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical Faculty, Trakya University, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Sevki","family":"Uyan\u0131k","sequence":"additional","affiliation":[{"name":"Department of Hematology, Medical Faculty, Trakya University, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Gurkan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Medical Faculty, Trakya University, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julide","family":"Duymaz","sequence":"additional","affiliation":[{"name":"Health Services Vocational College, Trakya University, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer Nuri","family":"Pamuk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Medical Faculty, Trakya University, Edirne, 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