{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T13:00:17Z","timestamp":1793710817873,"version":"4.6.1"},"reference-count":62,"publisher":"Manuscript Technomedia LLP","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phcog Rev"],"published-print":{"date-parts":[[2011]]},"DOI":"10.4103\/0973-7847.79105","type":"journal-article","created":{"date-parts":[[2011,5,6]],"date-time":"2011-05-06T11:33:26Z","timestamp":1304681606000},"page":"103","source":"Crossref","is-referenced-by-count":260,"title":["Feverfew (Tanacetum parthenium L.): A systematic review"],"prefix":"10.5530","volume":"5","author":[{"given":"Anil","family":"Pareek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Suthar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GarvendraS","family":"Rathore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3478","reference":[{"key":"key-10.4103\/0973-7847.79105-1","unstructured":"Duke JA . CRC Handbook of Medicinal Herbs. Boca Raton, FL: CRC Press; 1985."},{"key":"key-10.4103\/0973-7847.79105-2","unstructured":"Jackson B, McDonald RL . In: Dobelis IN, editor. Magic and Medicine of Plants. Pleasantville, NY: Reader\u2032s Digest Assoc.; 1986."},{"key":"key-10.4103\/0973-7847.79105-3","unstructured":"Meyer JE. The Herbalist. Hammond, IN: Hammond Book Co.; 1934."},{"key":"key-10.4103\/0973-7847.79105-4","unstructured":"Castleman M. The Healing Herbs. Emmaus, PA: Rodale Press; 1991."},{"key":"key-10.4103\/0973-7847.79105-5","first-page":"436","volume-title":"Feverfew.Hosp Pharm","author":"Chavez","year":"1999","journal-title":""},{"key":"key-10.4103\/0973-7847.79105-6","first-page":"251","volume-title":"Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L.extract in mice and rats","author":"Jain","year":"1999","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/0973-7847.79105-7","doi-asserted-by":"crossref","unstructured":"Heptinstall S, Awang DW, Dawson BA, Kindack D, Knight DW. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium (L.) Schultz-Bip.). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992;44:391-5.","DOI":"10.1111\/j.2042-7158.1992.tb03631.x"},{"key":"key-10.4103\/0973-7847.79105-8","first-page":"773","volume-title":"Herbal medications commonly used in the practice of rheumatology: Mechanisms of action, efficacy, and side effects","author":"Setty","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"key-10.4103\/0973-7847.79105-9","first-page":"2286","volume-title":"Feverfew for preventing migraine","author":"Pittler","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"key-10.4103\/0973-7847.79105-10","first-page":"2313","volume-title":"Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew.Involvement of sesquiterpene lactones and other components","author":"Sumner","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-11","first-page":"2543","volume-title":"Sesquiterpene Lactones and Other Constituents from Tanacetum parthenium","author":"Bohlmann","year":"1982","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-12","first-page":"709","volume-title":"Compounds extracted from feverfew that have anti-secretory activity contain an alpha-methylene butyrolactone unit","author":"Groenewegen","year":"1986","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-13","first-page":"471","volume-title":"3,4--Epoxy-8-deoxycumambrin B, A sesquiterpene lactone from Tanacetum parthenium","author":"Milbrodt","year":"1997","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-14","first-page":"940","volume-title":"Revised structures for guaianolide-methylenebutyro-lactones from feverfew","author":"Begley","year":"1989","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-15","first-page":"1301","volume-title":"Variations in lipophilic and polar flavonoids in the genus Tanacetum","author":"Williams","year":"1999","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-16","first-page":"417","volume-title":"The flavonoids of Tanacetum parthenium and T.vulgare and their anti-inflammatory properties","author":"Williams","year":"1999","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-17","first-page":"267","volume-title":"A biologically active lipophilic flavonol from Tanacetum parthenium","author":"Williams","year":"1995","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-18","first-page":"567","volume-title":"Bioactive flavonoids of Tanacetum parthenium revisited","author":"Long","year":"2003","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-19","first-page":"537","volume-title":"Anti-inflammatory activity sesquiterpene lactones and related compounds","author":"Hall","year":"1979","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/0973-7847.79105-20","doi-asserted-by":"crossref","unstructured":"Akpulat H, Tepe B, Sokmen A, Daferera D, Polissiou M. Composition of the essential oils of Tanacetum argyrophyllum (C. Koch) Tvzel. var. argyrophyllum and Tanacetum parthenium (L.) Schultz Bip. (Asteraceae) from Turkey. Biochem Syst Ecol 2005;33:511-6.","DOI":"10.1016\/j.bse.2004.10.006"},{"key":"key-10.4103\/0973-7847.79105-21","first-page":"515","volume-title":"A sesquiterpene coumarin ether from transformed roots of Tanacetum parthenium","author":"Kisiel","year":"1997","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-22","first-page":"781","volume-title":"Coniferaldehyde derivatives from tissue culture of Artemisia annua and Tanacetum parthenium","author":"Laiking","year":"1999","journal-title":"Phytochemistry"},{"key":"key-10.4103\/0973-7847.79105-23","first-page":"759","volume-title":"The anti-inflammatory natural product parthenolide from the medicinal herb feverfew directly binds to and inhibits IkappaB kinase","author":"0","year":"2001","journal-title":"Chem Biol"},{"key":"key-10.4103\/0973-7847.79105-24","first-page":"922","volume-title":"Extract of feverfew inhibits prostaglandin biosynthesis","author":"0","year":"1980","journal-title":"Lancet"},{"key":"key-10.4103\/0973-7847.79105-25","doi-asserted-by":"crossref","unstructured":"0Brown AM, Edwards CM, Davey MR, Power JB, Lowe KC. Pharmacological activity of feverfew (Tanacetum parthenium [L.] Schultz-Bip.): Assessment by inhibition of human polymorphonuclear leukocyte chemiluminescence in vitro. J Pharm Pharmacol 1997;49:558-61.","DOI":"10.1111\/j.2042-7158.1997.tb06841.x"},{"key":"key-10.4103\/0973-7847.79105-26","first-page":"181","volume-title":"Feverfew-an antithrombotic drug.?","author":"0Loecshe","year":"1988","journal-title":"Folia Haematol Int Mag Klin Morphol Blutforsch"},{"key":"key-10.4103\/0973-7847.79105-27","first-page":"1054","volume-title":"The active principle in feverfew","author":"0","year":"1981","journal-title":"Lancet"},{"key":"key-10.4103\/0973-7847.79105-28","first-page":"1071","volume-title":"Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes","author":"0Heptinstall","year":"1985","journal-title":"Lancet"},{"key":"key-10.4103\/0973-7847.79105-29","first-page":"653","volume-title":"A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium)","author":"0Makheja","year":"1982","journal-title":"Prostaglandins Leukot Med"},{"key":"key-10.4103\/0973-7847.79105-30","first-page":"743","volume-title":"Prostaglandin synthetase inhibitors in feverfew","author":"0Pugh","year":"1988","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-31","first-page":"81","volume-title":"Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: A cytotoxic effect","author":"Neill","year":"1987","journal-title":"Br J Clin Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-32","first-page":"737","volume-title":"Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta","author":"Barsby","year":"1992","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-33","first-page":"20","volume-title":"Feverfew and vascular smooth muscle: Extracts from fresh and dried plants show opposing pharmacological profiles, dependent upon sesquiterpene lactone content","author":"0Barsby","year":"1993","journal-title":"Planta Med"},{"key":"key-10.4103\/0973-7847.79105-34","first-page":"641","volume-title":"A chloroform extract of the herb feverfew blocks voltage-dependent potassium currents recorded from single smooth muscle cells","author":"0Barsby","year":"1993","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-35","first-page":"1","volume-title":"Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin","author":"0Bejar","year":"1996","journal-title":"J Ethnopharmacol"},{"key":"key-10.4103\/0973-7847.79105-36","first-page":"459","volume-title":"Extracts of feverfew may inhibit platelet behavior via neutralization of sulphydryl groups","author":"0Heptinstall","year":"1987","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-37","first-page":"501","volume-title":"Effects of an extract of feverfew on endothelial cell integrity and on cAMP in rabbit perfused aorta","author":"0Yasenetskaya","year":"1988","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-38","first-page":"447","volume-title":"Inhibition of platelet behaviour by feverfew: A mechanism of action involving sulphydryl groups","author":"0Heptinstall","year":"1988","journal-title":"Folia Haematol Int Mag Klin Morphol Blutforsch"},{"key":"key-10.4103\/0973-7847.79105-39","first-page":"689","volume-title":"Influence of substances affecting cell sulfhydryl\/disulfide status on adherence of human monocytes","author":"0Krause","year":"1990","journal-title":"Arzneimittelforschung"},{"key":"key-10.4103\/0973-7847.79105-40","first-page":"466","volume-title":"The activity of compounds extracted from feverfew on histamine release from rat mast cells","author":"0Hayes","year":"1987","journal-title":"J Pharm Pharmacol"},{"key":"key-10.4103\/0973-7847.79105-41","first-page":"176","volume-title":"Antileishmanial activity of parthenolide, a sesquiterpene lactone isolated from Tanacetum parthenium","author":"Tiuman","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.4103\/0973-7847.79105-42","first-page":"143","volume-title":"Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells","author":"Zhang","year":"2004","journal-title":"Cancer Lett"},{"key":"key-10.4103\/0973-7847.79105-43","first-page":"175","volume-title":"Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis","author":"0Zhang","year":"2004","journal-title":"Cancer Lett"},{"key":"key-10.4103\/0973-7847.79105-44","first-page":"126","volume-title":"Low concentrations of the feverfew component parthenolide inhibit in vitro growth of tumor lines in a cytostatic fashion","author":"0Ross","year":"1999","journal-title":"Planta Med"},{"key":"key-10.4103\/0973-7847.79105-45","first-page":"165","volume-title":"Microtubule-interfering activity of parthenolide","author":"0Miglietta","year":"2004","journal-title":"Chem Biol Interact"},{"key":"key-10.4103\/0973-7847.79105-46","first-page":"213","volume-title":"Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation","author":"0Kapadia","year":"2002","journal-title":"Pharmacol Res"},{"key":"key-10.4103\/0973-7847.79105-47","doi-asserted-by":"crossref","unstructured":"0Feverfew-a new drug or an old wives\u2032 remedy? Lancet 1985;1:1084.","DOI":"10.1016\/S0140-6736(85)92380-3"},{"key":"key-10.4103\/0973-7847.79105-48","first-page":"569","volume-title":"Efficacy of feverfew as prophylactic treatment of migraine","author":"Johnson","year":"1985","journal-title":"Br Med J"},{"key":"key-10.4103\/0973-7847.79105-49","first-page":"1128","volume-title":"Efficacy of feverfew as prophylactic treatment of migraine","author":"Waller","year":"1985","journal-title":"Br Med J"},{"key":"key-10.4103\/0973-7847.79105-50","first-page":"189","volume-title":"Randomised double-blind placebo-controlled trial of feverfew in migraine prevention","author":"0Murphy","year":"1988","journal-title":"Lancet"},{"key":"key-10.4103\/0973-7847.79105-51","first-page":"217","volume-title":"Progress in the medicinal chemistry of the 0 herb feverfew","author":"0","year":"1992","journal-title":"Prog Med Chem"},{"key":"key-10.4103\/0973-7847.79105-52","first-page":"776","volume-title":"Platelet aggregation in patients using feverfew for migraine","author":"Biggs","year":"1982","journal-title":"Lancet"},{"key":"key-10.4103\/0973-7847.79105-53","first-page":"523","volume-title":"The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis--a double-blind, multicentre, randomized placebo-controlled dose-response study","author":"0Pfaffenrath","year":"2002","journal-title":"Cephalalgia"},{"key":"key-10.4103\/0973-7847.79105-54","first-page":"34","volume-title":"Fever few: A headache for the consumer","author":"Awang","year":"1993","journal-title":"HerbalGram"},{"key":"key-10.4103\/0973-7847.79105-55","first-page":"511","volume-title":"An extract of feverfew inhibits interactions of human platelets with collagen substrates","author":"Losche","year":"1987","journal-title":"Thromb Res"},{"key":"key-10.4103\/0973-7847.79105-56","first-page":"225","volume-title":"Herbal medicines in migraine prevention.Randomized double-blind placebo-controlled crossover trial of a feverfew preparation","author":"DeWeerdt","year":"1996","journal-title":"Phytomedicine"},{"key":"key-10.4103\/0973-7847.79105-57","first-page":"547","volume-title":"Feverfew in rheumatoid arthritis: A double blind, placebo controlled study","author":"Pattrick","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"key-10.4103\/0973-7847.79105-58","first-page":"89","volume-title":"Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts","author":"Smith","year":"2001","journal-title":"Cell Immunol"},{"key":"key-10.4103\/0973-7847.79105-59","first-page":"508","volume-title":"Feverfew (Tanacetum parthenium) as prophylactic treatment for migraine: A double-blind placebo-controlled study","author":"Palevitch","year":"1997","journal-title":"Phytother Res"},{"key":"key-10.4103\/0973-7847.79105-60","first-page":"2200","volume-title":"Herbal medicinals: Selected clinical considerations focusing on known or potential drug-herb interactions","author":"Miller","year":"1998","journal-title":"Arch Intern Med"},{"key":"key-10.4103\/0973-7847.79105-61","first-page":"827","volume-title":"Feverfew and migraine","author":"Vickers","year":"1985","journal-title":"Br Med J"},{"key":"key-10.4103\/0973-7847.79105-62","first-page":"145","volume-title":"Chromosomal aberrations and sister chromatid exchanges in lymphocytes and urine mutagenicity of migraine patients: A comparison of chronic feverfew users and matched non-users","author":"Anderson","year":"1988","journal-title":"Hum Toxicol"}],"container-title":["Pharmacognosy Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:03:33Z","timestamp":1771578213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.phcogrev.com\/PharmacognRev-5-9-103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011]]}},"alternative-id":["79105"],"URL":"https:\/\/doi.org\/10.4103\/0973-7847.79105","relation":{},"ISSN":["0973-7847"],"issn-type":[{"value":"0973-7847","type":"print"}],"subject":[],"published":{"date-parts":[[2011]]}}}