{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:47:38Z","timestamp":1789627658506,"version":"build-2803163510"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"\n CONTEXT:<\/jats:title>\n Pathogenesis of uterine synechia remains unsolved, the causal relationship between synechia and infertility is not clearly established.<\/jats:p>\n <\/jats:sec>\n \n AIMS:<\/jats:title>\n To evaluate the rabbit as an experimental model for Asherman's syndrome using the endometrial curettage as trigger mechanism then to evaluate its impact on fertility.<\/jats:p>\n <\/jats:sec>\n \n SETTINGS AND DESIGN:<\/jats:title>\n Experimental study<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n 13 female rabbits. All submitted traumatic endometrial curettage. Animals of Group 1 (\n n<\/jats:italic>\n = 7) were sacrificed at various times following surgery (day 7, 15 and 30), animals of Group 2 (\n n<\/jats:italic>\n = 6) were bred and sacrificed during pregnancy. Main outcome were synechia occurring, number of implanted fetus, lumen surface\/ global horn perimeter ratio (LS-GHP ratio) and epithelium thickness.\n <\/jats:p>\n <\/jats:sec>\n \n STATISTICAL ANALYSIS:<\/jats:title>\n \n Means were compared using Student \u2018\n t<\/jats:italic>\n \u2019 test (\n P<\/jats:italic>\n < 0.05 was considered significant). Number of implantation sites of two horns were compared with the Wilcoxon test.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n No synechia have been observed. Examinations at Day 7, 15 and 30 demonstrate a complete regeneration of endometrium. We observed a significant diminished LS-GHP ratio at day 7 (0.042 \u00b1 0.004 vs 0.074 \u00b1 0.002 mm;\n P<\/jats:italic>\n = 0.013) with a higher simple columnar epithelium compared to control (16.6 \u00b1 3.39 vs 10.98 \u00b1 1.7;\n P<\/jats:italic>\n = 0.001). We observed a diminished ovum implantation in traumatized horns, even if it was not statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION:<\/jats:title>\n Even if no intrauterine adhesion were observed, this model represents a pathogenesis condition in the rabbit similar to intrauterine adhesions observed in the human with negative impact on implantation.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0974-1208.101017","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:58:07Z","timestamp":1347670687000},"page":"175-180","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of the rabbit as an experimental model for human uterine synechia"],"prefix":"10.4103","volume":"5","author":[{"given":"Mohamed","family":"Khrouf","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Human Reproduction, Aziza Othmana Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Morel","sequence":"additional","affiliation":[{"name":"INRA, UMR 1198 Biologie du D\u00e9veloppement et Reproduction, F-78350 Jouy en Josas, France"},{"name":"Maternit\u00e9 R\u00e9gionale Universitaire de Nancy, Universit\u00e9 Nancy 1 Henri Poincar\u00e9, 10 rue Heydenreich, 54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hafiz","sequence":"additional","affiliation":[{"name":"INRA, UMR 1198 Biologie du D\u00e9veloppement et Reproduction, F-78350 Jouy en Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Chavatte-Palmer","sequence":"additional","affiliation":[{"name":"INRA, UMR 1198 Biologie du D\u00e9veloppement et Reproduction, F-78350 Jouy en Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Fernandez","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bic\u00eatre, Service Gyn\u00e9cologie Obst\u00e9trique, 78 rue du G\u00e9n\u00e9ral Leclerc, 94270 Le Kremlin Bic\u00eatre, France"},{"name":"CESP-INSERM U1018, Reproduction et D\u00e9veloppement de l\u2019enfant, 82 rue du G\u00e9n\u00e9ral Leclerc, 94276 Le Kremlin Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris-Sud 11, Bic\u00eatre, 94270 Le Kremlin Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1471-0528.1950.tb06053.x","article-title":"Traumatic intrauterine adhesions","volume":"57","author":"Asherman","year":"1950","journal-title":"J Obstet Gynaecol Br 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