{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:33Z","timestamp":1787071293946,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,5]]},"abstract":"\n CONTEXT:<\/jats:title>\n A critical body mass of adipose tissue is essential for the normal development of female reproductive functions. Leptin, an adipocyte-derived hormone encoded by the \u2019Ob\u2019 gene has been proposed as a peripheral signal indicating the adequacy of nutritional status for reproductive functions. It is reported as a direct regulator of gametogenic and steroidogenic potential of ovary. Though leptin is widely present in reproductive tissues, its relationship to reproductive hormones is still poorly understood.<\/jats:p>\n <\/jats:sec>\n \n AIMS:<\/jats:title>\n \n Present investigation attempts to explore ovarian response to secretory profile of leptin and its impact on pregnancy outcome in women undergoing controlled ovarian hyperstimulation for\n in vitro<\/jats:italic>\n fertilization and embryo transfer (IVF-ET).\n <\/jats:p>\n <\/jats:sec>\n \n SETTINGS AND DESIGN:<\/jats:title>\n Patients enrolled for IVF-ET underwent pituitary-ovarian suppression by \u2018Long Protocol\u2019 GnRH-agonist downregulation followed by ovarian stimulation.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n Sera were procured at different phases of IVF-ET for the assay of estradiol, progesterone, human chorionic gonadotropin, and for leptin. Ovarian follicular fluids were also assayed for leptin. Luteinized granulosa cells were cultured\n in vitro<\/jats:italic>\n to evaluate their steroidogenic potential.\n <\/jats:p>\n <\/jats:sec>\n \n STATISTICAL ANALYSIS USED:<\/jats:title>\n \n Statistical analyses were done by student's t-test, ANOVA, and Chi-square tests as applicable. All results were expressed as Mean \u00b1 SE.\n P<\/jats:italic>\n values < 0.05 were considered significant.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Positive correlation was observed between serum and ovarian follicular fluid leptin. A negative correlation was noted between the serum leptin levels and endometrial thickness.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n Elevated leptin response may exert adverse impacts on pregnancy success during IVF-ET possibly by modulating uterine receptivity.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0974-1208.101021","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:58:07Z","timestamp":1347670687000},"page":"194-199","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Overt leptin response to controlled ovarian hyperstimulation negatively correlates with pregnancy outcome in in vitro fertilization--embryo transfer cycle"],"prefix":"10.4103","volume":"5","author":[{"given":"Jana","family":"Chakrabarti","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Presidency University (Erstwhile Presidency College), 86\/1, College Street, 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