{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T10:34:29Z","timestamp":1792838069116,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      Mature oocytes are prerequisite for achieving the process of\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      fertilization. Human chorionic gonadotropin (hCG) is the standard trigger used for stimulating ovulation but is associated with ovarian hyperstimulation syndrome (OHSS). Gonadotropin-releasing hormone agonist trigger achieves oocyte maturation and lowers the incidence of OHSS, but it has limitations of higher pregnancy loss rate and miscarriage rates. Coadministration of both hormones is found to improve the pregnancy rates and the number of mature oocytes retrieved. We aimed to assess if the dual trigger is better than the conventional hCG in triggering oocyte maturation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODOLOGY:<\/jats:title>\n                    <jats:p>The study included 76 female patients aged 24\u201343 years who were randomly divided into two groups with 38 patients in each arm. The study included patients with antimullerian hormone (AMH) &lt;4 ng\/ml, antral follicle counts (AFCs)\/ovary &lt;12. The study excluded high responders-AMH &gt;4 ng\/ml and AFC\/ovary &gt;12 to avoid OHSS risk with hCG trigger.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The study showed statistically insignificant differences between dual group versus hCG group in terms of the number of oocytes retrieved (10.0 \u00b1 5.6 vs. 8.7 \u00b1 5.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.2816), the number of mature oocytes recovered (8.4 \u00b1 5.0 vs. 7.2 \u00b1 4.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.2588), fertilization rate (5.9 \u00b1 4.2 vs. 5.6 \u00b1 3.3;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.7390), and the number of usable embryos on day 3 (4.0 \u00b1 3.0 vs. 4.0 \u00b1 2.4;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.8991).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The dual trigger is equivalent to hCG in triggering oocyte maturation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0974-1208.183506","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T07:07:37Z","timestamp":1465196857000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Evaluation of dual trigger with gonadotropin-releasing hormone agonist and human chorionic gonadotropin in improving oocyte maturity rates: A prospective randomized study"],"prefix":"10.4103","volume":"9","author":[{"given":"Nalini","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Nova IVI Fertility, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Nova IVI Fertility, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet Rana","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Nova IVI Fertility, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Nova IVI Fertility, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumkum","family":"Rani","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Nova IVI Fertility, New Delhi, 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