{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:57:51Z","timestamp":1791939471242,"version":"4.3.4"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec>\n                    <jats:title>CONTEXT:<\/jats:title>\n                    <jats:p>Fibroids are the most common tumors of the uterine cavity. Most of them are diagnosed during the reproductive age when the fertility is an important concern for the female. However, complications can occur after removal of fibroid (myomectomy) too for future pregnancy. Though myomectomy has been sighted as a cause of intrauterine adhesions data regarding the effect of myomectomy on endometrial cavity is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIMS:<\/jats:title>\n                    <jats:p>Evaluate the incidence of intrauterine adhesion formation after myomectomy and to identify the associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>In this prospective observational study, hysteroscopy was done in 51 infertile patients who had undergone myomectomy 3 months before in a tertiary care center from 2012 to 2015. The presence of intrauterine adhesions noted on hysteroscopy was investigated on the basis of size, number, location and type of fibroid removed, along with intraoperative breach of the uterine cavity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STATISTICAL ANALYSIS:<\/jats:title>\n                    <jats:p>\n                      Chi-square test was used for the calculating significant difference in frequency of discrete variables in two groups.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Intrauterine adhesions were seen in 11 out of 51 (21.57%) cases. No significant relationship between intrauterine adhesions and type, size or number of fibroid was observed. No statistical difference in the rate of adhesion formation was seen irrespective of breach of the uterine cavity during myomectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Intrauterine adhesion formation after myomectomy is not related to the type of surgery or the nature of fibroid. However, in all cases desiring fertility postoperative hysteroscopy is highly recommended to diagnose and treat these adhesions early.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0974-1208.183509","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T07:07:37Z","timestamp":1465196857000},"page":"107-111","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":28,"title":["Effect of myomectomy on endometrial cavity: A prospective study of 51 cases"],"prefix":"10.4103","volume":"9","author":[{"given":"Shilpa","family":"Bhandari","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitika","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Surgery, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250521","first-page":"814","article-title":"Fibroids (uterine myomatosis, leiomyomas)","volume":"05","author":"Lethaby","year":"2009","journal-title":"Clin Evid (Online)"},{"issue":"5 Suppl 1","key":"R2-20250521","first-page":"S194","article-title":"Practice Committee of the American Society for Reproductive Medicine. Myomas and reproductive function","volume":"86","year":"2006","journal-title":"Fertil Steril"},{"key":"R3-20250521","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/humrep\/15.4.869","article-title":"Pregnancy outcome and deliveries following laparoscopic myomectomy","volume":"15","author":"Dubuisson","year":"2000","journal-title":"Hum Reprod"},{"key":"R4-20250521","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/humupd\/dmt058","article-title":"Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: Comprehensive review, conference summary and future recommendations","volume":"20","author":"Segars","year":"2014","journal-title":"Hum Reprod Update"},{"key":"R5-20250521","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.fertnstert.2008.03.029","article-title":"Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity","volume":"93","author":"Rackow","year":"2010","journal-title":"Fertil Steril"},{"key":"R6-20250521","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1210\/jc.2010-1450","article-title":"Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-\u00df3","volume":"96","author":"Sinclair","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"R7-20250521","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/853269","article-title":"Intrauterine adhesions following conservative treatment of uterine fibroids","author":"Gambadauro","year":"2012","journal-title":"Obstet Gynecol Int 2012"},{"key":"R8-20250521","first-page":"161","article-title":"Intrauterine synechiae after myomectomy; laparotomy versus laparoscopy: Non-randomized interventional trial","volume":"13","author":"Asgari","year":"2015","journal-title":"Iran J Reprod Med"},{"key":"R9-20250521","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0002-9378(78)90322-8","article-title":"Hysteroscopic management of intrauterine adhesions","volume":"130","author":"March","year":"1978","journal-title":"Am J Obstet Gynecol"},{"key":"R10-20250521","first-page":"CD000475","article-title":"Barrier agents for adhesion prevention after gynaecological surgery","volume":"2","author":"Ahmad","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"R11-20250521","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000357489","article-title":"A rare case of Asherman's syndrome after open myomectomy: Sonographic investigations and possible underlying mechanisms","volume":"77","author":"Papoutsis","year":"2014","journal-title":"Gynecol Obstet Invest"},{"key":"R12-20250521","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2214\/ajr.160.4.8456668","article-title":"Hysterosalpingography before and after myomectomy: Clinical value and imaging findings","volume":"160","author":"Lev-Toaff","year":"1993","journal-title":"AJR Am J Roentgenol"},{"key":"R13-20250521","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/gyn.2005.21.95","article-title":"Clinically significant uterine synechiae caused by transmural uterine incisions","volume":"21","author":"Nakhuda","year":"2005","journal-title":"J Gynecol Surg"},{"key":"R14-20250521","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/humrep\/15.8.1751","article-title":"Prognostic factors of reproductive outcome after myomectomy in infertile patients","volume":"15","author":"Fauconnier","year":"2000","journal-title":"Hum Reprod"},{"key":"R15-20250521","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1074-3804(05)60478-1","article-title":"Role of endometrial suppression on the frequency of intrauterine adhesions after resectoscopic surgery","volume":"7","author":"Taskin","year":"2000","journal-title":"J Am Assoc Gynecol Laparosc"},{"key":"R16-20250521","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.fertnstert.2007.05.027","article-title":"Office hysteroscopic early lysis of intrauterine adhesion after transcervical resection of multiple apposing submucous myomas","volume":"89","author":"Yang","year":"2008","journal-title":"Fertil Steril"},{"key":"R17-20250521","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00404-013-2838-4","article-title":"A pilot study of Foley's catheter balloon for prevention of intrauterine adhesions following breach of uterine cavity in complex myoma surgery","volume":"288","author":"Gupta","year":"2013","journal-title":"Arch Gynecol Obstet"},{"key":"R18-20250521","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1447-0756.2007.00530.x","article-title":"Hysteroscopy after uterine fibroid embolization in women of fertile age","volume":"33","author":"Mara","year":"2007","journal-title":"J Obstet Gynaecol Res"},{"key":"R19-20250521","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejogrb.2014.04.034","article-title":"Intrauterine adhesions after open myomectomy: An audit","volume":"179","author":"Conforti","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R20-20250521","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jmig.2007.01.013","article-title":"Italian multicenter study on complications of laparoscopic myomectomy","volume":"14","author":"Sizzi","year":"2007","journal-title":"J Minim Invasive Gynecol"},{"key":"R21-20250521","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ejogrb.2005.04.012","article-title":"Effectiveness of antiadhesion barriers in preventing adhesion after myomectomy in patients with uterine leiomyoma","volume":"123","author":"Tsuji","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R22-20250521","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1080\/01443610310001604493","article-title":"Gonadotrophin-releasing hormones agonist therapy increases peritoneal fibrinolytic activity and prevents adhesion formation after myomectomy","volume":"23","author":"Imai","year":"2003","journal-title":"J Obstet Gynaecol"}],"container-title":["Journal of Human Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363858-201609020-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:51:18Z","timestamp":1787773878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363858-201609020-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-1208.183509","relation":{},"ISSN":["0974-1208","1998-4766"],"issn-type":[{"value":"0974-1208","type":"print"},{"value":"1998-4766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"2015-09-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}