{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:41:37Z","timestamp":1787071297952,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2011,1]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Insulin resistance (IR) is central to the pathogenesis of polycystic ovarian syndrome (PCOS), but tests for determining IR are elaborate, tedious and expensive.<\/jats:p>\n <\/jats:sec>\n \n AIMS:<\/jats:title>\n To evaluate if \u201c2-hour post-glucose insulin level\u201d is an effective indicator of IR and can aid in diagnosing IR in infertile PCOS women.<\/jats:p>\n <\/jats:sec>\n \n SETTINGS AND DESIGN:<\/jats:title>\n Observational study at infertility clinic of a tertiary care center.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n \n 50 infertile women with PCOS and 20 females with tubal\/male factor infertility were evaluated for the presence of IR, as defined by the fasting\/2-hour post-glucose insulin levels cutoffs of >25\/>41\n \u03bc<\/jats:italic>\n U\/mL, respectively. The clinical, metabolic and endocrinologic profile was determined in both the groups.\n <\/jats:p>\n <\/jats:sec>\n \n STATISTICAL ANALYSIS:<\/jats:title>\n Statistical analysis was performed using SPSS (Chicago, IL, USA).<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n Body mass index, post load glucose, insulin, glucose\/insulin ratio, area under curve (AUC) of glucose and insulin and insulinogenic index were significantly lower in the controls as compared to the PCOS group. \u201c2-hour post-glucose insulin levels\u201d were elevated in 88% of PCOS individuals but were normal in all females not suffering from PCOS. These levels significantly correlated with AUC of glucose and insulin, and insulinogenic index and inversely correlated with 2-hour glucose to insulin ratio (r=0.827, 0.749 and \u20130.732, respectively).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n \u201c2-hour post-glucose insulin levels\u201d appears to be a good indicator of IR. It can be a useful tool, especially in low resource setting where a single sample can confirm the diagnosis, thus reducing cost and repeat visits.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/0974-1208.82355","type":"journal-article","created":{"date-parts":[[2011,6,28]],"date-time":"2011-06-28T07:14:15Z","timestamp":1309245255000},"page":"20-22","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of 2-hour post glucose insulin levels in predicting insulin resistance in polycystic ovarian syndrome with infertility"],"prefix":"10.4103","volume":"4","author":[{"given":"Pikee","family":"Saxena","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Nigam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250926","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Frank","year":"1995","journal-title":"N Engl J Med"},{"key":"R2-20250926","first-page":"165","article-title":"Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women","volume":"84","author":"Legro","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"R3-20250926","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"R5-20250926","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2337\/dc06-1484","article-title":"The usefulness of the International Diabetes Federation and the National Cholesterol Education Program's Adult Treatment Panel III definitions of the metabolic syndrome in predicting coronary heart disease in subjects with type 2 diabetes","volume":"30","author":"Tong","year":"2007","journal-title":"Diabetes Care"},{"key":"R6-20250926","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/09513590903215581","article-title":"Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: A randomized, double-blind, and placebo control trial","volume":"8","author":"Fux Otta","year":"2009","journal-title":"Gynecol Endocrinol"},{"key":"R7-20250926","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1093\/humrep\/14.12.2963","article-title":"Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhea","volume":"14","author":"Pirwany","year":"1999","journal-title":"Hum Reprod"},{"key":"R8-20250926","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0026-0495(99)90113-0","article-title":"Metformin induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome","volume":"48","author":"Glueck","year":"1999","journal-title":"Metabolism"},{"key":"R9-20250926","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0974-1208.74156","article-title":"Effect of metformin therapy on 2-hour post-glucose insulin levels in patients of PCOS","volume":"3","author":"Saxena","year":"2010","journal-title":"J Hum Reprod Sci"}],"container-title":["Journal of Human Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01363858-201104010-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:18Z","timestamp":1787067858000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01363858-201104010-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-1208.82355","relation":{},"ISSN":["0974-1208","1998-4766"],"issn-type":[{"value":"0974-1208","type":"print"},{"value":"1998-4766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"2010-11-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-03-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}