{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:38:49Z","timestamp":1789605529962,"version":"build-2803163510"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To compare the efficacy of letrozole and clomiphene citrate (CC) in patients of anovulatory polycystic ovarian syndrome (PCOS) with infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>\n                      This prospective randomized clinical trial included 204 patients of PCOS. 98 patients (294 cycles) received 2.5\u20135 mg of letrozole; 106 patients (318 cycles) received 50\u2013100 mg of CC (both orally from Days 3\u20137 of menstrual cycle). The treatment continued for three cycles in both the groups. Main outcome measures: ovulation rate, endometrial thickness, and pregnancy rate. Statistical analysis was done using SPSS 13 software.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value less than 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean number of dominant follicles in letrozole groups and CC groups was 1.86\u00b10.26 and 1.92\u00b10.17, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.126). Number of ovulatory cycle in letrozole group was 196 (66.6%) versus 216 (67.9%) in CC group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.712). The mean mid-cycle endometrial thickness was 9.1\u00b10.3 mm in letrozole group and 6.3\u00b11.1 in CC group, which was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.014). The mean Estradiol [E2] level in clomiphene citrate group was significantly higher in CC group (364.2\u00b171.4 pg\/mL) than letrozole group (248.2\u00b1 42.2 pg\/mL). 43 patients from the letrozole group (43.8%) and 28 patients from the CC group (26.4%) became pregnant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Letrozole and CC have comparable ovulation rate. The effect of letrozole showed a better endometrial response and pregnancy rate compared with CC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0974-1208.97789","type":"journal-article","created":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T01:18:08Z","timestamp":1341191888000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":59,"title":["A prospective randomized trial comparing the efficacy of Letrozole and Clomiphene citrate in induction of ovulation in polycystic ovarian syndrome"],"prefix":"10.4103","volume":"5","author":[{"given":"Kallol Kumar","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS), New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinee","family":"Baruah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, All 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