{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:40:19Z","timestamp":1789609219240,"version":"build-2803163510"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Early primary graft failure after pediatric orthotopic heart transplantation (OHT) has a high mortality rate and can occur due to several causes including but not limited to prolonged graft ischemia time, suboptimal preimplant myocardial preservation, hyperacute rejection, and maladaptation of the graft to the host's hemodynamic status. Mechanical circulatory support with either extracorporeal membrane oxygenation (ECMO) or ventricular assist device has been used for the rescue of primary graft failure in pediatric patients after heart transplant. Cardiac arrest before ECMO initiation in these patients is associated with adverse neurologic outcome although those surviving to hospital discharge generally have excellent long-term outcome. We report a case of early primary graft failure after OHT who required ECMO support and successful rescue with plasmapheresis, immunoglobulins, and alemtuzumab.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/0974-2069.197063","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T06:06:10Z","timestamp":1482991570000},"page":"69-71","source":"Crossref","is-referenced-by-count":7,"title":["Early primary graft failure after a pediatric heart transplant and successful rescue with plasmapheresis, immunoglobulins, and alemtuzumab"],"prefix":"10.4103","volume":"10","author":[{"given":"Shashi","family":"Raj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Rusconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20240122","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/ejcts\/ezs115","article-title":"Mechanical circulatory support after paediatric heart transplantation","volume":"42","author":"Perri","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"R2-12-20240122","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jacc.2009.04.062","article-title":"Outcome of extracorporeal membrane oxygenation for early primary graft failure after pediatric heart transplantation","volume":"54","author":"Tissot","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"R3-12-20240122","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/ejcts\/ezt225","article-title":"The impact of mechanical circulatory support on outcomes in paediatric heart transplantation","volume":"44","author":"Botha","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"R4-12-20240122","first-page":"926","article-title":"Task force 2: Immunosuppression and rejection. In: The international society of heart and lung transplantation guidelines for the care of heart transplant recipients","volume":"29","author":"Taylor","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"R5-12-20240122","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.healun.2007.11.569","article-title":"Alemtuzumab (Campath-1H) induction in a pediatric heart transplant: Successful outcome and rationale for its use","volume":"27","author":"Das","year":"2008","journal-title":"J Heart Lung Transplant"},{"key":"R6-12-20240122","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.healun.2008.11.908","article-title":"HLA sensitization in pediatric pre-transplant cardiac patients supported by mechanical assist devices: The utility of Luminex","volume":"28","author":"Yang","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"R7-12-20240122","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.healun.2007.03.015","article-title":"Survival in allosensitized children after listing for cardiac transplantation","volume":"26","author":"Feingold","year":"2007","journal-title":"J Heart Lung Transplant"}],"container-title":["Annals of Pediatric Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01408568-201710010-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:16Z","timestamp":1786650016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01408568-201710010-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/0974-2069.197063","relation":{},"ISSN":["0974-2069"],"issn-type":[{"value":"0974-2069","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}